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A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome (PLATO)

Primary Purpose

Acute Coronary Syndrome

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Ticagrelor

Clopidogrel

About this trial

This is an interventional treatment trial for Acute Coronary Syndrome focused on measuring ACS, Acute coronary syndrome, Heart attack, Unstable angina, Coronary artery disease

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Male or female 18 years or older who has been hospitalised for chest pain and potential ACS
Females of child-bearing potential must have a negative pregnancy test at enrollment and be willing to use 2 methods of reliable contraception

Exclusion Criteria:

Persons with moderate or severe liver disease
Persons who have already been treated with an invasive (angioplasty) procedure for the current episode of ACS
Persons who are being treated with blood clotting agents that cannot be stopped

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Experimental

Arm Label

Clopidogrel

Ticagrelor

Arm Description

Oral treatment

Outcomes

Primary Outcome Measures

Participants With Any Event From the Composite of Death From Vascular Causes, Myocardial Infarction (MI), and Stroke

Participants with death from vascular causes, MI, or stroke. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. Intention To Treat (ITT) analysis of whole population. Events were adjudicated by an endpoint committee.

Participants With Any Major Bleeding Event

Participants with major (fatal/life-threatening or other) bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. Events were adjudicated by an endpoint committee.

Secondary Outcome Measures

Participants With Any Event From the Composite of Death From Vascular Causes, MI, and Stroke for the Subgroup of Patients With Intent for Invasive Management at Randomization

Participants with death from vascular causes, MI, or stroke. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT analysis of intent for invasive management population. Events were adjudicated by an endpoint committee.

Participants With Any Event From the Composite of All-cause Mortality, MI, and Stroke

Participants with death from any cause, MI, or stroke. If no event, censoring occurs at the earliest of patient withdrawal of consent or date of scheduled withdrawal from therapy. ITT analysis of whole population. Events were adjudicated by an endpoint committee.

Participants With Any Event From the Composite of Death From Vascular Causes, MI (Including Silent), Stroke, Recurrent Ischemia, Transient Ischemic Attack (TIA) and Other Arterial Thrombotic Events.

Participants with death from vascular causes, MI, stroke, recurrent ischemia, or other thrombotic events. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT analysis of whole population. Events were adjudicated.

Participants With MI Event

Participants with MI event. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT (intention to treat) analysis of whole population. Events were adjudicated by an endpoint committee.

Participants With Death From Vascular Causes

Participants with death from vascular causes. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT (intention to treat) analysis of whole population. Events were adjudicated by an endpoint committee.

Participants With Stroke

Participants with stroke. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT (intention to treat) analysis of whole population. Events were adjudicated by an endpoint committee.

Participants With Death From Any Cause

Participants with death from any cause. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT (intention to treat) analysis of whole population. Events were adjudicated by an endpoint committee.

Participants With Non-CABG (Coronary Artery Bypass Graft) Related Major Bleeding

Participants with non CABG related major (fatal/life-threatening or other) bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. Events were adjudicated by an endpoint committee.

Participants With Major or Minor Bleeding

Participants with major (fatal/life-threatening or other) or minor bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. Events were adjudicated by an endpoint committee.

Participants With Non-procedural Major Bleeding

Participants with non-procedural major bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. Events were adjudicated by an endpoint committee.

Participants With Coronary Artery Bypass Graft (CABG) Major Bleeding

Participants with a major CABG-related bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. All CABG surgeries were submitted for adjudication by an endpoint committee as potential bleeds.

Participants With Coronary Artery Bypass Graft (CABG) Major Fatal/Life-threatening Bleeding

Number of participants with a major fatal/life-threatening CABG-related bleed by a study protocol scale based on need for treatment, number of transfusions, hemoglobin decrease, and other factors. All CABG surgeries were submitted for adjudication by an endpoint committee as potential bleeds.

Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24-hour ECG Recorders for 1 Week Following Randomization

Number of participants who were observed to have at least 1 ventricular pause of at least 3 seconds. Population is all patients who were observed over 2 week-long periods. Pauses were flagged algorithmically and confirmed by Thrombolysis in Myocardial Infarction (TIMI) group cardiologists.

Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24 Hour ECG Recorders for 1 Week at 1 Month Following Randomization

Full Information

NCT ID

NCT00391872

First Posted

October 23, 2006

Last Updated

February 10, 2012

Sponsor

AstraZeneca

1. Study Identification

Unique Protocol Identification Number

NCT00391872

Brief Title

A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome

Acronym

PLATO

Official Title

A Randomised, Double-blind, Parallel Group, Phase 3, Efficacy and Safety Study of Ticagrelor Compared With Clopidogrel for Prevention of Vascular Events in Patients With Non-ST or ST Elevation Acute Coronary Syndromes (ACS) [PLATO- a Study of PLATelet Inhibition and Patient Outcomes]

Study Type

Interventional

2. Study Status

Record Verification Date

February 2012

Overall Recruitment Status

Completed

Study Start Date

October 2006 (undefined)

Primary Completion Date

March 2009 (Actual)

Study Completion Date

March 2009 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AstraZeneca

4. Oversight

5. Study Description

Brief Summary

Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. Ticagrelor is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progress or the imminent threat of a heart attack. ACS is usually caused by the formation of a blood clot in an artery that partially or totally blocks the blood supply to a portion of the heart muscle. Ticagrelor will be compared with clopidogrel to determine which drug, when either is used in conjunction with aspirin, is better at reducing deaths from vascular causes, future heart attacks and/or strokes in patients with ACS.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Acute Coronary Syndrome

Keywords

ACS, Acute coronary syndrome, Heart attack, Unstable angina, Coronary artery disease

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigatorOutcomes Assessor

Allocation

Randomized

Enrollment

18624 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Clopidogrel

Arm Type

Active Comparator

Arm Description

Oral treatment

Arm Title

Ticagrelor

Arm Type

Experimental

Arm Description

Oral treatment

Intervention Type

Drug

Intervention Name(s)

Ticagrelor

Other Intervention Name(s)

AZD6140

Intervention Description

Ticagrelor (AZD6140) 90 mg twice daily dose (BD)

Intervention Type

Drug

Intervention Name(s)

Clopidogrel

Other Intervention Name(s)

Plavix®

Intervention Description

Clopidogrel 75 mg once daily dose (ODD)

Primary Outcome Measure Information:

Title

Participants With Any Event From the Composite of Death From Vascular Causes, Myocardial Infarction (MI), and Stroke

Description

Time Frame

Randomization up to 12 months

Title

Participants With Any Major Bleeding Event

Description

Time Frame

First dosing up to 12 months

Secondary Outcome Measure Information:

Title

Participants With Any Event From the Composite of Death From Vascular Causes, MI, and Stroke for the Subgroup of Patients With Intent for Invasive Management at Randomization

Description

Participants with death from vascular causes, MI, or stroke. If no event, censoring occurs at the earliest of patient withdrawal consent or date of scheduled withdrawal from therapy. ITT analysis of intent for invasive management population. Events were adjudicated by an endpoint committee.

Time Frame

Randomization up to 12 months

Title

Participants With Any Event From the Composite of All-cause Mortality, MI, and Stroke

Description

Time Frame

Randomization up to 12 months

Title

Participants With Any Event From the Composite of Death From Vascular Causes, MI (Including Silent), Stroke, Recurrent Ischemia, Transient Ischemic Attack (TIA) and Other Arterial Thrombotic Events.

Description

Time Frame

Randomization up to 12 months

Title

Participants With MI Event

Description

Time Frame

Randomization up to 12 months

Title

Participants With Death From Vascular Causes

Description

Time Frame

Randomization up to 12 months

Title

Participants With Stroke

Description

Time Frame

Randomization up to 12 months

Title

Participants With Death From Any Cause

Description

Time Frame

Randomization up to 12 months

Title

Participants With Non-CABG (Coronary Artery Bypass Graft) Related Major Bleeding

Description

Time Frame

First dosing up to 12 months

Title

Participants With Major or Minor Bleeding

Description

Time Frame

First dosing up to 12 months

Title

Participants With Non-procedural Major Bleeding

Description

Time Frame

First dosing up to 12 months

Title

Participants With Coronary Artery Bypass Graft (CABG) Major Bleeding

Description

Time Frame

First dosing up to 12 months

Title

Participants With Coronary Artery Bypass Graft (CABG) Major Fatal/Life-threatening Bleeding

Description

Time Frame

First dosing up to 12 months

Title

Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24-hour ECG Recorders for 1 Week Following Randomization

Description

Time Frame

1-week period following randomization

Title

Participants With Ventricular Pauses of Greater Than or Equal to 3 Seconds in Patients Monitored by Holter 24 Hour ECG Recorders for 1 Week at 1 Month Following Randomization

Description

Time Frame

1-week period following randomization

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Male or female 18 years or older who has been hospitalised for chest pain and potential ACS Females of child-bearing potential must have a negative pregnancy test at enrollment and be willing to use 2 methods of reliable contraception Exclusion Criteria: Persons with moderate or severe liver disease Persons who have already been treated with an invasive (angioplasty) procedure for the current episode of ACS Persons who are being treated with blood clotting agents that cannot be stopped

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Robert Harrington, MD

Organizational Affiliation

Duke Clinical Research Institute

Official's Role

Principal Investigator

First Name & Middle Initial & Last Name & Degree

Lars Wallentin, MD

Organizational Affiliation

Uppsala Clinical Research Centre

Official's Role

Principal Investigator

First Name & Middle Initial & Last Name & Degree

Jonathan C. Fox, MD

Organizational Affiliation

AstraZeneca

Official's Role

Study Director

Facility Information:

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Birmingham

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Alabama

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United States

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Huntsville

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Mobile

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Healdsburg

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Los Angeles

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Roseville

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Sacramento

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San Diego

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Torrance

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Fort Collins

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Danbury

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Atlantis

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Daytona Beach

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Ft. Lauderdale

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Hollywood

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Jupiter

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Melbourne

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Miami Beach

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Ocala

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Orlando

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Ormond Beach

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Pensacola

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Kalamazoo

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Lansing

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Laper

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Pontiac

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Royal Oak

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Saginaw

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Joplin

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Albuquerque

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Brooklyn

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Buffalo

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Kingston

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Rochester

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Syracuse

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Williamsville

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Chapel Hill

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Charlotte

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Greensboro

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High Point

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Raleigh

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Cleveland

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Columbus

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Kettering

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Zanesville

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Tulsa

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Bend

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Danville

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Doylestown

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Harrisburg

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Lancaster

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Langhorne

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Philadelphia

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Pittsburgh

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Sayre

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Sellersville

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Wormleysburg

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York

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Providence

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Wakefield

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Anderson

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South Carolina

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United States

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Charleston

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Columbia

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South Carolina

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Greenville

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Rapid City

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Jackson

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Tennessee

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United States

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Knoxville

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Tennessee

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Memphis

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Amarillo

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Austin

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Texas

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Dallas

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Houston

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Texas

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Lubbock

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San Antonio

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Texas

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San Marcos

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Tyler

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Victoria

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Texas

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United States

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Burlington

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Vermont

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United States

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Falls Church

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Virginia

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United States

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Fredericksburg

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Norfolk

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Winchester

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Virginia

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Everett

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Tacoma

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Morgantown

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West Virginia

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United States

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Green Bay

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Wisconsin

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United States

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Adrogue

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Buenos Aires

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Argentina

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Capital Federal

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Buenos Aires

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Argentina

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Ciudad Autonoma de Bs. As.

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Buenos Aires

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Argentina

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Quilmes

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Argentina

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Moron

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Pcia. de Buenos Aires

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Argentina

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Rosario

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Santa Fe

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Argentina

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Tucuman

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Tucuman - Argentina

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Argentina

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Buenos Aires

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Argentina

Facility Name

Research Site

City

Cordoba

Country

Argentina

Facility Name

Research Site

City

Corrientes

Country

Argentina

Facility Name

Research Site

City

Salta

Country

Argentina

Facility Name

Research Site

City

San Miguel de Tucuman

Country

Argentina

Facility Name

Research Site

City

Santa Fe

Country

Argentina

Facility Name

Research Site

City

Bruce

State/Province

Australian Capital Territory

Country

Australia

Facility Name

Research Site

City

Chermside

State/Province

Queensland

Country

Australia

Facility Name

Research Site

City

Herston

State/Province

Queensland

Country

Australia

Facility Name

Research Site

City

Woolloongabba

State/Province

Queensland

Country

Australia

Facility Name

Research Site

City

Bedford Park

State/Province

South Australia

Country

Australia

Facility Name

Research Site

City

Dandenong

State/Province

Victoria

Country

Australia

Facility Name

Research Site

City

Geelong

State/Province

Victoria

Country

Australia

Facility Name

Research Site

City

Melbourne

State/Province

Victoria

Country

Australia

Facility Name

Research Site

City

Perth

State/Province

Western Australia

Country

Australia

Facility Name

Research Site

City

Feldkirch

Country

Austria

Facility Name

Research Site

City

Freistadt

Country

Austria

Facility Name

Research Site

City

Graz

Country

Austria

Facility Name

Research Site

City

Innsbruck

Country

Austria

Facility Name

Research Site

City

Linz

Country

Austria

Facility Name

Research Site

City

Modling

Country

Austria

Facility Name

Research Site

City

Villach

Country

Austria

Facility Name

Research Site

City

Wien

Country

Austria

Facility Name

Research Site

City

Aalst

Country

Belgium

Facility Name

Research Site

City

Bouge

Country

Belgium

Facility Name

Research Site

City

Brasschaat

Country

Belgium

Facility Name

Research Site

City

Brussels (anderlecht)

Country

Belgium

Facility Name

Research Site

City

Charleroi

Country

Belgium

Facility Name

Research Site

City

Edegem

Country

Belgium

Facility Name

Research Site

City

Genk

Country

Belgium

Facility Name

Research Site

City

Hasselt

Country

Belgium

Facility Name

Research Site

City

HUY

Country

Belgium

Facility Name

Research Site

City

Liege

Country

Belgium

Facility Name

Research Site

City

Mechelen

Country

Belgium

Facility Name

Research Site

City

MOL

Country

Belgium

Facility Name

Research Site

City

Wilrijk

Country

Belgium

Facility Name

Research Site

City

Maceio

State/Province

Country

Brazil

Facility Name

Research Site

City

Salvador

State/Province

Country

Brazil

Facility Name

Research Site

City

Brasilia

State/Province

Country

Brazil

Facility Name

Research Site

City

Goiania

State/Province

Country

Brazil

Facility Name

Research Site

City

Belo Horizonte

State/Province

Country

Brazil

Facility Name

Research Site

City

Uberlandia

State/Province

Country

Brazil

Facility Name

Research Site

City

Campo Grande

State/Province

Country

Brazil

Facility Name

Research Site

City

Recife

State/Province

Country

Brazil

Facility Name

Research Site

City

Curitiba

State/Province

Country

Brazil

Facility Name

Research Site

City

Maringa

State/Province

Country

Brazil

Facility Name

Research Site

City

Rio de Janeiro

State/Province

Country

Brazil

Facility Name

Research Site

City

Natal

State/Province

Country

Brazil

Facility Name

Research Site

City

Porto Alegre

State/Province

Country

Brazil

Facility Name

Research Site

City

Sao Jose

State/Province

Country

Brazil

Facility Name

Research Site

City

Aracaju

State/Province

Country

Brazil

Facility Name

Research Site

City

S.j.rio Preto

State/Province

Country

Brazil

Facility Name

Research Site

City

Sao Paulo

State/Province

Country

Brazil

Facility Name

Research Site

City

Campinas

Country

Brazil

Facility Name

Research Site

City

Burgas

Country

Bulgaria

Facility Name

Research Site

City

Dimitrovgrad

Country

Bulgaria

Facility Name

Research Site

City

Gabrovo

Country

Bulgaria

Facility Name

Research Site

City

Haskovo

Country

Bulgaria

Facility Name

Research Site

City

Kazanlak

Country

Bulgaria

Facility Name

Research Site

City

Pleven

Country

Bulgaria

Facility Name

Research Site

City

Plovdiv

Country

Bulgaria

Facility Name

Research Site

City

Ruse

Country

Bulgaria

Facility Name

Research Site

City

Russe

Country

Bulgaria

Facility Name

Research Site

City

Smolian

Country

Bulgaria

Facility Name

Research Site

City

Sofia

Country

Bulgaria

Facility Name

Research Site

City

Varna

Country

Bulgaria

Facility Name

Research Site

City

Calgary

State/Province

Alberta

Country

Canada

Facility Name

Research Site

City

Edmonton

State/Province

Alberta

Country

Canada

Facility Name

Research Site

City

Campbell River

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Kelowna

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

New Westminster

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Penticton

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Surrey

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Vancouver

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Victoria

State/Province

British Columbia

Country

Canada

Facility Name

Research Site

City

Winnipeg

State/Province

Manitoba

Country

Canada

Facility Name

Research Site

City

Saint John

State/Province

New Brunswick

Country

Canada

Facility Name

Research Site

City

St. John's

State/Province

Newfoundland and Labrador

Country

Canada

Facility Name

Research Site

City

Brockville

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

Cambridge

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

Cornwall

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

London

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

Newmarket

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

Oshawa

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

Ottawa

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

Scarborough

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

Toronto

State/Province

Ontario

Country

Canada

Facility Name

Research Site

City

Laval

State/Province

Quebec

Country

Canada

Facility Name

Research Site

City

Montreal

State/Province

Quebec

Country

Canada

Facility Name

Research Site

City

Saint-georges

State/Province

Quebec

Country

Canada

Facility Name

Research Site

City

Sherbrooke

State/Province

Quebec

Country

Canada

Facility Name

Research Site

City

Thetford Mines

State/Province

Quebec

Country

Canada

Facility Name

Research Site

City

Regina

State/Province

Saskatchewan

Country

Canada

Facility Name

Research Site

City

Quebec

Country

Canada

Facility Name

Research Site

City

Guangzhou

State/Province

Guangdong

Country

China

Facility Name

Research Site

City

Shenyang

State/Province

Liaoning

Country

China

Facility Name

Research Site

City

Chengdu

State/Province

Sichuan

Country

China

Facility Name

Research Site

City

Beijing

Country

China

Facility Name

Research Site

City

Hang Zhou

Country

China

Facility Name

Research Site

City

Shanghai, Pudong

Country

China

Facility Name

Research Site

City

Brno

State/Province

Country

Czech Republic

Facility Name

Research Site

City

Hradec Kralove

Country

Czech Republic

Facility Name

Research Site

City

Jihlava

Country

Czech Republic

Facility Name

Research Site

City

Kladno

Country

Czech Republic

Facility Name

Research Site

City

Liberec

Country

Czech Republic

Facility Name

Research Site

City

Olomouc

Country

Czech Republic

Facility Name

Research Site

City

Ostrava-poruba

Country

Czech Republic

Facility Name

Research Site

City

Pardubice

Country

Czech Republic

Facility Name

Research Site

City

Praha

Country

Czech Republic

Facility Name

Research Site

City

Slany

Country

Czech Republic

Facility Name

Research Site

City

Teplice

Country

Czech Republic

Facility Name

Research Site

City

Usti Nad Labem

Country

Czech Republic

Facility Name

Research Site

City

Usti Nad Orlici

Country

Czech Republic

Facility Name

Research Site

City

Zlin

Country

Czech Republic

Facility Name

Research Site

City

Znojmo

Country

Czech Republic

Facility Name

Research Site

City

Esbjerg

Country

Denmark

Facility Name

Research Site

City

Fredericia

Country

Denmark

Facility Name

Research Site

City

Frederiksberg

Country

Denmark

Facility Name

Research Site

City

Frederikssund

Country

Denmark

Facility Name

Research Site

City

Glostrup

Country

Denmark

Facility Name

Research Site

City

Hellerup

Country

Denmark

Facility Name

Research Site

City

Herlev

Country

Denmark

Facility Name

Research Site

City

Herning

Country

Denmark

Facility Name

Research Site

City

Hillerod

Country

Denmark

Facility Name

Research Site

City

Hjorring

Country

Denmark

Facility Name

Research Site

City

Holbaek

Country

Denmark

Facility Name

Research Site

City

Horsens

Country

Denmark

Facility Name

Research Site

City

Hvidovre

Country

Denmark

Facility Name

Research Site

City

Kobenhavn

Country

Denmark

Facility Name

Research Site

City

Koge

Country

Denmark

Facility Name

Research Site

City

Kolding

Country

Denmark

Facility Name

Research Site

City

Naestved

Country

Denmark

Facility Name

Research Site

City

Odense C

Country

Denmark

Facility Name

Research Site

City

Roskilde

Country

Denmark

Facility Name

Research Site

City

Silkeborg

Country

Denmark

Facility Name

Research Site

City

Slagelse

Country

Denmark

Facility Name

Research Site

City

Viborg

Country

Denmark

Facility Name

Research Site

City

Hus (helsinki)

Country

Finland

Facility Name

Research Site

City

Jyvaskyla

Country

Finland

Facility Name

Research Site

City

Kokkola

Country

Finland

Facility Name

Research Site

City

Kuopio

Country

Finland

Facility Name

Research Site

City

Lahti

Country

Finland

Facility Name

Research Site

City

Lappeenranta

Country

Finland

Facility Name

Research Site

City

Pori

Country

Finland

Facility Name

Research Site

City

Rovaniemi

Country

Finland

Facility Name

Research Site

City

Turku

Country

Finland

Facility Name

Research Site

City

Abbeville

Country

France

Facility Name

Research Site

City

Allauch

Country

France

Facility Name

Research Site

City

Arras

Country

France

Facility Name

Research Site

City

Avignon

Country

France

Facility Name

Research Site

City

Bayonne

Country

France

Facility Name

Research Site

City

Besancon

Country

France

Facility Name

Research Site

City

Brest

Country

France

Facility Name

Research Site

City

Caen

Country

France

Facility Name

Research Site

City

Cholet

Country

France

Facility Name

Research Site

City

Creteil

Country

France

Facility Name

Research Site

City

Croix

Country

France

Facility Name

Research Site

City

Dijon

Country

France

Facility Name

Research Site

City

Douai

Country

France

Facility Name

Research Site

City

Falaise

Country

France

Facility Name

Research Site

City

Frejus

Country

France

Facility Name

Research Site

City

La Rochelle

Country

France

Facility Name

Research Site

City

Lagny Sur Marne

Country

France

Facility Name

Research Site

City

Lille

Country

France

Facility Name

Research Site

City

Limoges

Country

France

Facility Name

Research Site

City

Lomme

Country

France

Facility Name

Research Site

City

Marseille

Country

France

Facility Name

Research Site

City

Nimes

Country

France

Facility Name

Research Site

City

Orleans

Country

France

Facility Name

Research Site

City

Paris

Country

France

Facility Name

Research Site

City

PAU

Country

France

Facility Name

Research Site

City

Pessac

Country

France

Facility Name

Research Site

City

Quincy Sous Senart

Country

France

Facility Name

Research Site

City

Rennes

Country

France

Facility Name

Research Site

City

Rouen

Country

France

Facility Name

Research Site

City

Senlis

Country

France

Facility Name

Research Site

City

Strasbourg

Country

France

Facility Name

Research Site

City

Toulouse

Country

France

Facility Name

Research Site

City

Tourcoing

Country

France

Facility Name

Research Site

City

Valenciennes

Country

France

Facility Name

Research Site

City

Tbilisi

Country

Georgia

Facility Name

Research Site

City

Aschaffenburg

Country

Germany

Facility Name

Research Site

City

Bad Mergentheim

Country

Germany

Facility Name

Research Site

City

Bad Nauheim

Country

Germany

Facility Name

Research Site

City

Bad Rothenfelde

Country

Germany

Facility Name

Research Site

City

Berlin

Country

Germany

Facility Name

Research Site

City

Bochum

Country

Germany

Facility Name

Research Site

City

Bonn

Country

Germany

Facility Name

Research Site

City

Cloppenburg

Country

Germany

Facility Name

Research Site

City

Coburg

Country

Germany

Facility Name

Research Site

City

Dortmund

Country

Germany

Facility Name

Research Site

City

Dresden

Country

Germany

Facility Name

Research Site

City

Duisburg

Country

Germany

Facility Name

Research Site

City

Erfurt

Country

Germany

Facility Name

Research Site

City

Essen

Country

Germany

Facility Name

Research Site

City

Esslingen

Country

Germany

Facility Name

Research Site

City

Frankfurt

Country

Germany

Facility Name

Research Site

City

Gottingen

Country

Germany

Facility Name

Research Site

City

Greifswald

Country

Germany

Facility Name

Research Site

City

Halle

Country

Germany

Facility Name

Research Site

City

Hamburg

Country

Germany

Facility Name

Research Site

City

Hannover

Country

Germany

Facility Name

Research Site

City

Heidelberg

Country

Germany

Facility Name

Research Site

City

Jena

Country

Germany

Facility Name

Research Site

City

Kiel

Country

Germany

Facility Name

Research Site

City

Krefeld

Country

Germany

Facility Name

Research Site

City

Limburg

Country

Germany

Facility Name

Research Site

City

Lubeck

Country

Germany

Facility Name

Research Site

City

Mainz

Country

Germany

Facility Name

Research Site

City

Merseburg

Country

Germany

Facility Name

Research Site

City

Monchengladbach

Country

Germany

Facility Name

Research Site

City

Muhlheim An Der Ruhr

Country

Germany

Facility Name

Research Site

City

Munster

Country

Germany

Facility Name

Research Site

City

Regensburg

Country

Germany

Facility Name

Research Site

City

Rostock

Country

Germany

Facility Name

Research Site

City

ULM

Country

Germany

Facility Name

Research Site

City

Warendorf

Country

Germany

Facility Name

Research Site

City

Witten

Country

Germany

Facility Name

Research Site

City

Wuppertal

Country

Germany

Facility Name

Research Site

City

Wurzburg

Country

Germany

Facility Name

Research Site

City

Heraklion

State/Province

Crete

Country

Greece

Facility Name

Research Site

City

Athens

Country

Greece

Facility Name

Research Site

City

Larissa

Country

Greece

Facility Name

Research Site

City

Patra

Country

Greece

Facility Name

Research Site

City

Piraeus

Country

Greece

Facility Name

Research Site

City

Thessaloniki

Country

Greece

Facility Name

Research Site

City

Hong Kong

Country

Hong Kong

Facility Name

Research Site

City

Budapest

Country

Hungary

Facility Name

Research Site

City

Cegled

Country

Hungary

Facility Name

Research Site

City

Debrecen

Country

Hungary

Facility Name

Research Site

City

Gyula

Country

Hungary

Facility Name

Research Site

City

Hodmez-vasarhely

Country

Hungary

Facility Name

Research Site

City

Kaposvar

Country

Hungary

Facility Name

Research Site

City

Kecskemet

Country

Hungary

Facility Name

Research Site

City

Mosonmagyarovar

Country

Hungary

Facility Name

Research Site

City

Pecs

Country

Hungary

Facility Name

Research Site

City

Szekesfehervar

Country

Hungary

Facility Name

Research Site

City

Zalaegerszeg

Country

Hungary

Facility Name

Research Site

City

Hyderabad

State/Province

Andhrapradesh

Country

India

Facility Name

Research Site

City

Vijayawada

State/Province

Andhrapradesh

Country

India

Facility Name

Research Site

City

New Delhi

State/Province

Delhi

Country

India

Facility Name

Research Site

City

Ahmedabad

State/Province

Gujarat

Country

India

Facility Name

Research Site

City

Gandhinagar

State/Province

Gujarat

Country

India

Facility Name

Research Site

City

Vadodara

State/Province

Gujarat

Country

India

Facility Name

Research Site

City

Bangalore

State/Province

Karnataka

Country

India

Facility Name

Research Site

City

Kochi

State/Province

Kerala

Country

India

Facility Name

Research Site

City

Thrissur

State/Province

Kerala

Country

India

Facility Name

Research Site

City

Bhopal

State/Province

Madhya Pradesh

Country

India

Facility Name

Research Site

City

Mumbai

State/Province

Maharashtra

Country

India

Facility Name

Research Site

City

Nagpur

State/Province

Maharashtra

Country

India

Facility Name

Research Site

City

Patiala

State/Province

Punjab

Country

India

Facility Name

Research Site

City

Bikaner

State/Province

Rajasthan

Country

India

Facility Name

Research Site

City

Jaipur

State/Province

Rajasthan

Country

India

Facility Name

Research Site

City

Chennai

State/Province

Tamilnadu

Country

India

Facility Name

Research Site

City

Coimabatore

State/Province

Tamilnadu

Country

India

Facility Name

Research Site

City

Kolkata

State/Province

West Bengal

Country

India

Facility Name

Research Site

City

Denpasar

State/Province

Bali

Country

Indonesia

Facility Name

Research Site

City

Bandung

State/Province

Jawa Barat

Country

Indonesia

Facility Name

Research Site

City

Surabaya

State/Province

Jawa Timur

Country

Indonesia

Facility Name

Research Site

City

Jakarta

Country

Indonesia

Facility Name

Research Site

City

Makassar

Country

Indonesia

Facility Name

Research Site

City

Semarang

Country

Indonesia

Facility Name

Research Site

City

Afula

Country

Israel

Facility Name

Research Site

City

Ashkelon

Country

Israel

Facility Name

Research Site

City

Beer Sheva

Country

Israel

Facility Name

Research Site

City

Hadera

Country

Israel

Facility Name

Research Site

City

Haifa

Country

Israel

Facility Name

Research Site

City

Holon

Country

Israel

Facility Name

Research Site

City

Jerusalem

Country

Israel

Facility Name

Research Site

City

Poriya M.p. Lower Galilee

Country

Israel

Facility Name

Research Site

City

Rehovot

Country

Israel

Facility Name

Research Site

City

Tel Aviv

Country

Israel

Facility Name

Research Site

City

Zerifin

Country

Israel

Facility Name

Research Site

City

Ancona

State/Province

Country

Italy

Facility Name

Research Site

City

Bari

State/Province

Country

Italy

Facility Name

Research Site

City

Bergamo

State/Province

Country

Italy

Facility Name

Research Site

City

Caserta

State/Province

Country

Italy

Facility Name

Research Site

City

Catania

State/Province

Country

Italy

Facility Name

Research Site

City

Ferrara

State/Province

Country

Italy

Facility Name

Research Site

City

Foggia

State/Province

Country

Italy

Facility Name

Research Site

City

San Giovanni Rotondo

State/Province

Country

Italy

Facility Name

Research Site

City

Bagno A Ripoli

State/Province

Country

Italy

Facility Name

Research Site

City

Firenze

State/Province

Country

Italy

Facility Name

Research Site

City

Legnano

State/Province

Country

Italy

Facility Name

Research Site

City

Milano

State/Province

Country

Italy

Facility Name

Research Site

City

Monza

State/Province

Country

Italy

Facility Name

Research Site

City

Rozzano

State/Province

Country

Italy

Facility Name

Research Site

City

Mantova

State/Province

Country

Italy

Facility Name

Research Site

City

Modena

State/Province

Country

Italy

Facility Name

Research Site

City

Pescara

State/Province

Country

Italy

Facility Name

Research Site

City

Parma

State/Province

Country

Italy

Facility Name

Research Site

City

Pavia

State/Province

Country

Italy

Facility Name

Research Site

City

Ostia Lido

State/Province

Roma

Country

Italy

Facility Name

Research Site

City

Sassari

State/Province

Country

Italy

Facility Name

Research Site

City

Treviso

State/Province

Country

Italy

Facility Name

Research Site

City

Varese

State/Province

Country

Italy

Facility Name

Research Site

City

Mestre

State/Province

Country

Italy

Facility Name

Research Site

City

Verona

State/Province

Country

Italy

Facility Name

Research Site

City

Massa Carrara

Country

Italy

Facility Name

Research Site

City

Napoli

Country

Italy

Facility Name

Research Site

City

Novara

Country

Italy

Facility Name

Research Site

City

Roma

Country

Italy

Facility Name

Research Site

City

Seongnam

State/Province

Gyeonggido

Country

Korea, Republic of

Facility Name

Research Site

City

Daegu

Country

Korea, Republic of

Facility Name

Research Site

City

Gwangju

Country

Korea, Republic of

Facility Name

Research Site

City

Seoul

Country

Korea, Republic of

Facility Name

Research Site

City

Suwon

Country

Korea, Republic of

Facility Name

Research Site

City

Wonju

Country

Korea, Republic of

Facility Name

Research Site

City

Kuching

State/Province

Sarawak

Country

Malaysia

Facility Name

Research Site

City

Kuala Lumpur

State/Province

Wilayah Persekutuan

Country

Malaysia

Facility Name

Research Site

City

Penang

Country

Malaysia

Facility Name

Research Site

City

Mexico

State/Province

Distrito Federal

Country

Mexico

Facility Name

Research Site

City

Guadalajara

State/Province

Jalisco

Country

Mexico

Facility Name

Research Site

City

Zapopan

State/Province

Jalisco

Country

Mexico

Facility Name

Research Site

City

Monterrey

State/Province

Nuevo Leon

Country

Mexico

Facility Name

Research Site

City

Durango

Country

Mexico

Facility Name

Research Site

City

Puebla

Country

Mexico

Facility Name

Research Site

City

Alkmaar

Country

Netherlands

Facility Name

Research Site

City

Almelo

Country

Netherlands

Facility Name

Research Site

City

Amersfoort

Country

Netherlands

Facility Name

Research Site

City

Amsterdam

Country

Netherlands

Facility Name

Research Site

City

Apeldoorn

Country

Netherlands

Facility Name

Research Site

City

Arnhem

Country

Netherlands

Facility Name

Research Site

City

Assen

Country

Netherlands

Facility Name

Research Site

City

Blaricum

Country

Netherlands

Facility Name

Research Site

City

Breda

Country

Netherlands

Facility Name

Research Site

City

Capelle Aan Den Ijssel

Country

Netherlands

Facility Name

Research Site

City

Delft

Country

Netherlands

Facility Name

Research Site

City

Den Haag

Country

Netherlands

Facility Name

Research Site

City

Deventer

Country

Netherlands

Facility Name

Research Site

City

Dordrecht

Country

Netherlands

Facility Name

Research Site

City

Drachten

Country

Netherlands

Facility Name

Research Site

City

EDE

Country

Netherlands

Facility Name

Research Site

City

Eindhoven

Country

Netherlands

Facility Name

Research Site

City

Goes

Country

Netherlands

Facility Name

Research Site

City

Gorinchem

Country

Netherlands

Facility Name

Research Site

City

Gouda

Country

Netherlands

Facility Name

Research Site

City

Haarlem

Country

Netherlands

Facility Name

Research Site

City

Hardenberg

Country

Netherlands

Facility Name

Research Site

City

Harderwijk

Country

Netherlands

Facility Name

Research Site

City

Heerlen

Country

Netherlands

Facility Name

Research Site

City

Helmond

Country

Netherlands

Facility Name

Research Site

City

Hilversum

Country

Netherlands

Facility Name

Research Site

City

Leeuwarden

Country

Netherlands

Facility Name

Research Site

City

Maastricht

Country

Netherlands

Facility Name

Research Site

City

Nieuwegein

Country

Netherlands

Facility Name

Research Site

City

Nijmegen

Country

Netherlands

Facility Name

Research Site

City

Rotterdam

Country

Netherlands

Facility Name

Research Site

City

Spijkenisse

Country

Netherlands

Facility Name

Research Site

City

Tiel

Country

Netherlands

Facility Name

Research Site

City

Tilburg

Country

Netherlands

Facility Name

Research Site

City

Veldhoven

Country

Netherlands

Facility Name

Research Site

City

Vlaardingen

Country

Netherlands

Facility Name

Research Site

City

Arendal

Country

Norway

Facility Name

Research Site

City

Bergen

Country

Norway

Facility Name

Research Site

City

Bodo

Country

Norway

Facility Name

Research Site

City

Drammen

Country

Norway

Facility Name

Research Site

City

Flekkefjord

Country

Norway

Facility Name

Research Site

City

Gjovik

Country

Norway

Facility Name

Research Site

City

Hamar

Country

Norway

Facility Name

Research Site

City

Kongsberg

Country

Norway

Facility Name

Research Site

City

Kristiansand

Country

Norway

Facility Name

Research Site

City

Lillehammer

Country

Norway

Facility Name

Research Site

City

Nordbyhagen

Country

Norway

Facility Name

Research Site

City

Notodden

Country

Norway

Facility Name

Research Site

City

Oslo

Country

Norway

Facility Name

Research Site

City

RUD

Country

Norway

Facility Name

Research Site

City

Tromso

Country

Norway

Facility Name

Research Site

City

Tynset

Country

Norway

Facility Name

Research Site

City

Cebu

Country

Philippines

Facility Name

Research Site

City

Davao City

Country

Philippines

Facility Name

Research Site

City

Manila

Country

Philippines

Facility Name

Research Site

City

Pasig City

Country

Philippines

Facility Name

Research Site

City

Quezon City

Country

Philippines

Facility Name

Research Site

City

Bialystok

Country

Poland

Facility Name

Research Site

City

Bielsko-biala

Country

Poland

Facility Name

Research Site

City

Bydgoszcz

Country

Poland

Facility Name

Research Site

City

Bytom

Country

Poland

Facility Name

Research Site

City

Czestochowa

Country

Poland

Facility Name

Research Site

City

Elblag

Country

Poland

Facility Name

Research Site

City

Gda?sk

Country

Poland

Facility Name

Research Site

City

Gdynia

Country

Poland

Facility Name

Research Site

City

Grodzisk Mazowiecki

Country

Poland

Facility Name

Research Site

City

Inowroclaw

Country

Poland

Facility Name

Research Site

City

Katowice

Country

Poland

Facility Name

Research Site

City

Krakow

Country

Poland

Facility Name

Research Site

City

Lodz

Country

Poland

Facility Name

Research Site

City

Lublin

Country

Poland

Facility Name

Research Site

City

Olawa

Country

Poland

Facility Name

Research Site

City

Olsztyn

Country

Poland

Facility Name

Research Site

City

Opole

Country

Poland

Facility Name

Research Site

City

Ostrowiec Swietokrzyski

Country

Poland

Facility Name

Research Site

City

Plock

Country

Poland

Facility Name

Research Site

City

Poznan

Country

Poland

Facility Name

Research Site

City

Radom

Country

Poland

Facility Name

Research Site

City

Szczecin

Country

Poland

Facility Name

Research Site

City

Tarnow

Country

Poland

Facility Name

Research Site

City

Torun

Country

Poland

Facility Name

Research Site

City

Walbrzych

Country

Poland

Facility Name

Research Site

City

Warszawa

Country

Poland

Facility Name

Research Site

City

Wejherowo

Country

Poland

Facility Name

Research Site

City

Wloclawek

Country

Poland

Facility Name

Research Site

City

Wroclaw

Country

Poland

Facility Name

Research Site

City

Zamosc

Country

Poland

Facility Name

Research Site

City

Amadora

Country

Portugal

Facility Name

Research Site

City

Aveiro

Country

Portugal

Facility Name

Research Site

City

Braga

Country

Portugal

Facility Name

Research Site

City

Coimbra

Country

Portugal

Facility Name

Research Site

City

Leiria

Country

Portugal

Facility Name

Research Site

City

Lisboa

Country

Portugal

Facility Name

Research Site

City

Penafiel

Country

Portugal

Facility Name

Research Site

City

Santa Maria Da Feira

Country

Portugal

Facility Name

Research Site

City

Santarem

Country

Portugal

Facility Name

Research Site

City

Setubal

Country

Portugal

Facility Name

Research Site

City

Vila Nova de Gaia

Country

Portugal

Facility Name

Research Site

City

Vila Real

Country

Portugal

Facility Name

Research Site

City

San Juan

Country

Puerto Rico

Facility Name

Research Site

City

Pitesti

State/Province

Arges

Country

Romania

Facility Name

Research Site

City

Cluj Napoca

State/Province

Cluj

Country

Romania

Facility Name

Research Site

City

Braila

Country

Romania

Facility Name

Research Site

City

Brasov

Country

Romania

Facility Name

Research Site

City

Bucharest

Country

Romania

Facility Name

Research Site

City

Buzau

Country

Romania

Facility Name

Research Site

City

Craiova

Country

Romania

Facility Name

Research Site

City

Iasi

Country

Romania

Facility Name

Research Site

City

Suceava

Country

Romania

Facility Name

Research Site

City

Khanty-mansiysk

State/Province

Khanty-mansiysk Autonomous Dis

Country

Russian Federation

Facility Name

Research Site

City

Barnaul

Country

Russian Federation

Facility Name

Research Site

City

Ekaterinburg

Country

Russian Federation

Facility Name

Research Site

City

Irkutsk

Country

Russian Federation

Facility Name

Research Site

City

Kaliningrad

Country

Russian Federation

Facility Name

Research Site

City

Kazan

Country

Russian Federation

Facility Name

Research Site

City

Kemerovo

Country

Russian Federation

Facility Name

Research Site

City

Krasnodar

Country

Russian Federation

Facility Name

Research Site

City

Krasnoyarsk

Country

Russian Federation

Facility Name

Research Site

City

Moscow

Country

Russian Federation

Facility Name

Research Site

City

Murmansk

Country

Russian Federation

Facility Name

Research Site

City

Nizhniy Novgorod

Country

Russian Federation

Facility Name

Research Site

City

Novosibirsk

Country

Russian Federation

Facility Name

Research Site

City

Rostov-na-donu

Country

Russian Federation

Facility Name

Research Site

City

Samara

Country

Russian Federation

Facility Name

Research Site

City

St. Petersburg

Country

Russian Federation

Facility Name

Research Site

City

Tomsk

Country

Russian Federation

Facility Name

Research Site

City

Tyumen

Country

Russian Federation

Facility Name

Research Site

City

Vladivostok

Country

Russian Federation

Facility Name

Research Site

City

Singapore

Country

Singapore

Facility Name

Research Site

City

Bratislava

Country

Slovakia

Facility Name

Research Site

City

Kosice

Country

Slovakia

Facility Name

Research Site

City

Liptovsky Mikulas

Country

Slovakia

Facility Name

Research Site

City

Martin

Country

Slovakia

Facility Name

Research Site

City

Nitra

Country

Slovakia

Facility Name

Research Site

City

Nove Zamky

Country

Slovakia

Facility Name

Research Site

City

Piestany

Country

Slovakia

Facility Name

Research Site

City

Ruzomberok

Country

Slovakia

Facility Name

Research Site

City

Trnava

Country

Slovakia

Facility Name

Research Site

City

Zilina

Country

Slovakia

Facility Name

Research Site

City

Somerset West

State/Province

Cape Town

Country

South Africa

Facility Name

Research Site

City

Bloemfontein

State/Province

Free State

Country

South Africa

Facility Name

Research Site

City

Cape Town

Country

South Africa

Facility Name

Research Site

City

Pretoria

Country

South Africa

Facility Name

Research Site

City

Malaga

State/Province

Andalucia

Country

Spain

Facility Name

Research Site

City

Sevilla

State/Province

Andalucia

Country

Spain

Facility Name

Research Site

City

Gijon

State/Province

Asturias

Country

Spain

Facility Name

Research Site

City

Barcelona

State/Province

Cataluna

Country

Spain

Facility Name

Research Site

City

Lerida

State/Province

Cataluna

Country

Spain

Facility Name

Research Site

City

Terrassa

State/Province

Cataluna

Country

Spain

Facility Name

Research Site

City

Madrid

State/Province

Comunidad de Madrid

Country

Spain

Facility Name

Research Site

City

Valencia

State/Province

Comunidad Valenciana

Country

Spain

Facility Name

Research Site

City

Caceres

State/Province

Extremadura

Country

Spain

Facility Name

Research Site

City

Vigo(pontevedra)

State/Province

Galicia

Country

Spain

Facility Name

Research Site

City

Palma de Mallorca

State/Province

Islas Baleares

Country

Spain

Facility Name

Research Site

City

Boras

Country

Sweden

Facility Name

Research Site

City

Eksjo

Country

Sweden

Facility Name

Research Site

City

Eskilstuna

Country

Sweden

Facility Name

Research Site

City

Falun

Country

Sweden

Facility Name

Research Site

City

Halmstad

Country

Sweden

Facility Name

Research Site

City

Jonkoping

Country

Sweden

Facility Name

Research Site

City

Kalmar

Country

Sweden

Facility Name

Research Site

City

Karlskrona

Country

Sweden

Facility Name

Research Site

City

Lidkoping

Country

Sweden

Facility Name

Research Site

City

Linkoping

Country

Sweden

Facility Name

Research Site

City

Ljungby

Country

Sweden

Facility Name

Research Site

City

Lund

Country

Sweden

Facility Name

Research Site

City

Ostersund

Country

Sweden

Facility Name

Research Site

City

Skovde

Country

Sweden

Facility Name

Research Site

City

Stockholm

Country

Sweden

Facility Name

Research Site

City

Sundsvall

Country

Sweden

Facility Name

Research Site

City

Uppsala

Country

Sweden

Facility Name

Research Site

City

Vasteras

Country

Sweden

Facility Name

Research Site

City

Mendrisio

State/Province

Ticino

Country

Switzerland

Facility Name

Research Site

City

Bellinzona

Country

Switzerland

Facility Name

Research Site

City

Bern

Country

Switzerland

Facility Name

Research Site

City

Geneve

Country

Switzerland

Facility Name

Research Site

City

Kreuzlingen

Country

Switzerland

Facility Name

Research Site

City

Lugano

Country

Switzerland

Facility Name

Research Site

City

Niao-song-shiang

State/Province

Kaohsiung

Country

Taiwan

Facility Name

Research Site

City

Kweishan Shiang

State/Province

Taoyuan Hsien

Country

Taiwan

Facility Name

Research Site

City

Taipei

Country

Taiwan

Facility Name

Research Site

City

Bangkok

Country

Thailand

Facility Name

Research Site

City

Chiang Mai

Country

Thailand

Facility Name

Research Site

City

Khon Kaen

Country

Thailand

Facility Name

Research Site

City

Istanbul

State/Province

Kartal

Country

Turkey

Facility Name

Research Site

City

Ankara

State/Province

Sihhiye

Country

Turkey

Facility Name

Research Site

City

Adana

Country

Turkey

Facility Name

Research Site

City

Antalya

Country

Turkey

Facility Name

Research Site

City

Mersin

Country

Turkey

Facility Name

Research Site

City

Dnepropetrovsk

Country

Ukraine

Facility Name

Research Site

City

Donetsk

Country

Ukraine

Facility Name

Research Site

City

Kharkov

Country

Ukraine

Facility Name

Research Site

City

Kiev

Country

Ukraine

Facility Name

Research Site

City

Makiyivka

Country

Ukraine

Facility Name

Research Site

City

Airdrie

State/Province

Lanarkshire

Country

United Kingdom

Facility Name

Research Site

City

Belfast

State/Province

Northern Ireland

Country

United Kingdom

Facility Name

Research Site

City

Basingstoke

Country

United Kingdom

Facility Name

Research Site

City

Birmingham

Country

United Kingdom

Facility Name

Research Site

City

Blackpool

Country

United Kingdom

Facility Name

Research Site

City

Dundee

Country

United Kingdom

Facility Name

Research Site

City

Edinburgh

Country

United Kingdom

Facility Name

Research Site

City

Glasgow

Country

United Kingdom

Facility Name

Research Site

City

Leicester

Country

United Kingdom

Facility Name

Research Site

City

London

Country

United Kingdom

Facility Name

Research Site

City

Manchester

Country

United Kingdom

Facility Name

Research Site

City

Middlesborough

Country

United Kingdom

Facility Name

Research Site

City

Poole

Country

United Kingdom

Facility Name

Research Site

City

Sheffield

Country

United Kingdom

Facility Name

Research Site

City

Swansea

Country

United Kingdom

12. IPD Sharing Statement

Citations:

PubMed Identifier

35224730

Citation

Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.

Results Reference

derived

PubMed Identifier

34195679

Citation

Samman KN, Mehanna P, Takla E, Grenier JC, Chan MY, Lopes RD, Neely ML, Wang TY, Newby LK, Becker RC, Lordkipanidze M, Ruiz M, Hussin JG, Jolicoeur EM. Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel. Cell Rep Med. 2021 Jun 4;2(6):100299. doi: 10.1016/j.xcrm.2021.100299. eCollection 2021 Jun 15.

Results Reference

derived

PubMed Identifier

34115329

Citation

Thi Thu Nguyen T, Van Do D, Mellstrom C, Quang Nguyen T, Manh Pham H, Van Hoang S, Cong Luu T, Le Phuong T. Cost-Effectiveness of Ticagrelor Compared with Clopidogrel in Patients with Acute Coronary Syndrome from Vietnamese Healthcare Payers' Perspective. Adv Ther. 2021 Jul;38(7):4026-4039. doi: 10.1007/s12325-021-01743-5. Epub 2021 Jun 11.

Results Reference

derived

PubMed Identifier

33998271

Citation

Mahmoodi BK, Eriksson N, Vos GJA, Meijer K, Siegbahn A, James S, Wallentin L, Ten Berg JM. Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis. J Am Heart Assoc. 2021 Jun;10(11):e020025. doi: 10.1161/JAHA.120.020025. Epub 2021 May 17.

Results Reference

derived

PubMed Identifier

32809893

Citation

Gregersen I, Michelsen AE, Lunde NN, Akerblom A, Lakic TG, Skjelland M, Ryeng Skagen K, Becker RC, Lindback J, Himmelmann A, Solberg R, Johansen HT, James SK, Siegbahn A, Storey RF, Kontny F, Aukrust P, Ueland T, Wallentin L, Halvorsen B. Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial. J Am Heart Assoc. 2020 Sep;9(17):e016360. doi: 10.1161/JAHA.120.016360. Epub 2020 Aug 15.

Results Reference

derived

PubMed Identifier

31975352

Citation

Sumaya W, Wallentin L, James SK, Siegbahn A, Gabrysch K, Himmelmann A, Ajjan RA, Storey RF. Impaired Fibrinolysis Predicts Adverse Outcome in Acute Coronary Syndrome Patients with Diabetes: A PLATO Sub-Study. Thromb Haemost. 2020 Mar;120(3):412-422. doi: 10.1055/s-0039-1701011. Epub 2020 Jan 23.

Results Reference

derived

PubMed Identifier

31835039

Citation

Ueland T, Akerblom A, Ghukasyan T, Michelsen AE, Becker RC, Bertilsson M, Budaj A, Cornel JH, Himmelmann A, James SK, Siegbahn A, Storey RF, Kontny F, Aukrust P, Wallentin L; PLATO Investigators. ALCAM predicts future cardiovascular death in acute coronary syndromes: Insights from the PLATO trial. Atherosclerosis. 2020 Jan;293:35-41. doi: 10.1016/j.atherosclerosis.2019.11.031. Epub 2019 Nov 29.

Results Reference

derived

PubMed Identifier

31554419

Citation

Andersen T, Ueland T, Ghukasyan Lakic T, Akerblom A, Bertilsson M, Aukrust P, Michelsen AE, James SK, Becker RC, Storey RF, Wallentin L, Siegbahn A, Kontny F. C-X-C Ligand 16 Is an Independent Predictor of Cardiovascular Death and Morbidity in Acute Coronary Syndromes. Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2402-2410. doi: 10.1161/ATVBAHA.119.312633. Epub 2019 Sep 26.

Results Reference

derived

PubMed Identifier

31108273

Citation

Akerblom A, Wojdyla DM, Wallentin L, James SK, de Souza Brito F, Steg PG, Cannon CP, Katus HA, Himmelmann A, Storey RF, Becker RC, Lopes RD; PLATO Investigators. Ticagrelor in patients with heart failure after acute coronary syndromes-Insights from the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J. 2019 Jul;213:57-65. doi: 10.1016/j.ahj.2019.04.006. Epub 2019 Apr 18.

Results Reference

derived

PubMed Identifier

30857464

Citation

Franchi F, James SK, Ghukasyan Lakic T, Budaj AJ, Cornel JH, Katus HA, Keltai M, Kontny F, Lewis BS, Storey RF, Himmelmann A, Wallentin L, Angiolillo DJ; PLATO Investigators. Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y12 Receptor Antagonist Effects in Patients With Acute Coronary Syndromes: Insights From the PLATO Trial. J Am Heart Assoc. 2019 Mar 19;8(6):e011139. doi: 10.1161/JAHA.118.011139.

Results Reference

derived

PubMed Identifier

30427997

Citation

Lindholm D, James SK, Gabrysch K, Storey RF, Himmelmann A, Cannon CP, Mahaffey KW, Steg PG, Held C, Siegbahn A, Wallentin L. Association of Multiple Biomarkers With Risk of All-Cause and Cause-Specific Mortality After Acute Coronary Syndromes: A Secondary Analysis of the PLATO Biomarker Study. JAMA Cardiol. 2018 Dec 1;3(12):1160-1166. doi: 10.1001/jamacardio.2018.3811.

Results Reference

derived

PubMed Identifier

29910052

Citation

Inohara T, Pieper K, Wojdyla DM, Patel MR, Jones WS, Tricoci P, Mahaffey KW, James SK, Alexander JH, Lopes RD, Wallentin L, Ohman EM, Roe MT, Vemulapalli S. Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome. Am Heart J. 2018 Jul;201:25-32. doi: 10.1016/j.ahj.2018.03.013. Epub 2018 Mar 28.

Results Reference

derived

PubMed Identifier

29330256

Citation

Ueland T, Akerblom A, Ghukasyan T, Michelsen AE, Aukrust P, Becker RC, Bertilsson M, Himmelmann A, James SK, Siegbahn A, Storey RF, Kontny F, Wallentin L; PLATO (Platelet Inhibition and Patient Outcomes) Trial Investigators. Osteoprotegerin Is Associated With Major Bleeding But Not With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes: Insights From the PLATO (Platelet Inhibition and Patient Outcomes) Trial. J Am Heart Assoc. 2018 Jan 12;7(2):e007009. doi: 10.1161/JAHA.117.007009.

Results Reference

derived

PubMed Identifier

28761675

Citation

Bellavia A, Wallentin L, Orsini N, James SK, Cannon CP, Himmelmann A, Sundstrom J, Renlund H, Lytsy P. Time-based measures of treatment effect: reassessment of ticagrelor and clopidogrel from the PLATO trial. Open Heart. 2017 Jun 1;4(2):e000557. doi: 10.1136/openhrt-2016-000557. eCollection 2017.

Results Reference

derived

PubMed Identifier

28411246

Citation

Lindholm D, Hagstrom E, James SK, Becker RC, Cannon CP, Himmelmann A, Katus HA, Maurer G, Lopez-Sendon JL, Steg PG, Storey RF, Siegbahn A, Wallentin L. Growth Differentiation Factor 15 at 1 Month After an Acute Coronary Syndrome Is Associated With Increased Risk of Major Bleeding. J Am Heart Assoc. 2017 Apr 14;6(4):e005580. doi: 10.1161/JAHA.117.005580.

Results Reference

derived

PubMed Identifier

27932413

Citation

Lindholm D, James SK, Bertilsson M, Becker RC, Cannon CP, Giannitsis E, Harrington RA, Himmelmann A, Kontny F, Siegbahn A, Steg PG, Storey RF, Velders MA, Weaver WD, Wallentin L; PLATO Investigators. Biomarkers and Coronary Lesions Predict Outcomes after Revascularization in Non-ST-Elevation Acute Coronary Syndrome. Clin Chem. 2017 Feb;63(2):573-584. doi: 10.1373/clinchem.2016.261271. Epub 2016 Dec 8.

Results Reference

derived

PubMed Identifier

27160944

Citation

Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.

Results Reference

derived

PubMed Identifier

26908625

Citation

Johansson A, Eriksson N, Lindholm D, Varenhorst C, James S, Syvanen AC, Axelsson T, Siegbahn A, Barratt BJ, Becker RC, Himmelmann A, Katus HA, Steg PG, Storey RF, Wallentin L; PLATO Investigators. Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome. Hum Mol Genet. 2016 Apr 1;25(7):1447-56. doi: 10.1093/hmg/ddw012. Epub 2016 Jan 21.

Results Reference

derived

PubMed Identifier

26848185

Citation

Velders MA, Abtan J, Angiolillo DJ, Ardissino D, Harrington RA, Hellkamp A, Himmelmann A, Husted S, Katus HA, Meier B, Schulte PJ, Storey RF, Wallentin L, Gabriel Steg P, James SK; PLATO Investigators. Safety and efficacy of ticagrelor and clopidogrel in primary percutaneous coronary intervention. Heart. 2016 Apr;102(8):617-25. doi: 10.1136/heartjnl-2015-308963. Epub 2016 Feb 4.

Results Reference

derived

PubMed Identifier

26810596

Citation

Bui AH, Cannon CP, Steg PG, Storey RF, Husted S, Guo J, Im K, James SK, Michelson EL, Himmelmann A, Held C, Varenhorst C, Wallentin L, Scirica BM. Relationship Between Early and Late Nonsustained Ventricular Tachycardia and Cardiovascular Death in Patients With Acute Coronary Syndrome in the Platelet Inhibition and Patient Outcomes (PLATO) Trial. Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e002951. doi: 10.1161/CIRCEP.115.002951.

Results Reference

derived

PubMed Identifier

26452988

Citation

Andell P, James SK, Cannon CP, Cyr DD, Himmelmann A, Husted S, Keltai M, Koul S, Santoso A, Steg PG, Storey RF, Wallentin L, Erlinge D; PLATO Investigators. Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes and Chronic Obstructive Pulmonary Disease: An Analysis From the Platelet Inhibition and Patient Outcomes (PLATO) Trial. J Am Heart Assoc. 2015 Oct 9;4(10):e002490. doi: 10.1161/JAHA.115.002490.

Results Reference

derived

PubMed Identifier

26417057

Citation

Hagstrom E, James SK, Bertilsson M, Becker RC, Himmelmann A, Husted S, Katus HA, Steg PG, Storey RF, Siegbahn A, Wallentin L; PLATO Investigators. Growth differentiation factor-15 level predicts major bleeding and cardiovascular events in patients with acute coronary syndromes: results from the PLATO study. Eur Heart J. 2016 Apr 21;37(16):1325-33. doi: 10.1093/eurheartj/ehv491. Epub 2015 Sep 28.

Results Reference

derived

PubMed Identifier

26089177

Citation

Mahaffey KW, Hager R, Wojdyla D, White HD, Armstrong PW, Alexander JH, Tricoci P, Lopes RD, Ohman EM, Roe MT, Harrington RA, Wallentin L. Meta-analysis of intracranial hemorrhage in acute coronary syndromes: incidence, predictors, and clinical outcomes. J Am Heart Assoc. 2015 Jun 18;4(6):e001512. doi: 10.1161/JAHA.114.001512.

Results Reference

derived

PubMed Identifier

26027629

Citation

Kang HJ, Clare RM, Gao R, Held C, Himmelmann A, James SK, Lim ST, Santoso A, Yu CM, Wallentin L, Becker RC; PLATO Investigators. Ticagrelor versus clopidogrel in Asian patients with acute coronary syndrome: A retrospective analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial. Am Heart J. 2015 Jun;169(6):899-905.e1. doi: 10.1016/j.ahj.2015.03.015. Epub 2015 Mar 31.

Results Reference

derived

PubMed Identifier

26027627

Citation

Velders MA, Wallentin L, Becker RC, van Boven AJ, Himmelmann A, Husted S, Katus HA, Lindholm D, Morais J, Siegbahn A, Storey RF, Wernroth L, James SK; PLATO Investigators. Biomarkers for risk stratification of patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention: Insights from the Platelet Inhibition and Patient Outcomes trial. Am Heart J. 2015 Jun;169(6):879-889.e7. doi: 10.1016/j.ahj.2015.02.019. Epub 2015 Mar 5.

Results Reference

derived

PubMed Identifier

25935875

Citation

Varenhorst C, Eriksson N, Johansson A, Barratt BJ, Hagstrom E, Akerblom A, Syvanen AC, Becker RC, James SK, Katus HA, Husted S, Steg PG, Siegbahn A, Voora D, Teng R, Storey RF, Wallentin L; PLATO Investigators. Effect of genetic variations on ticagrelor plasma levels and clinical outcomes. Eur Heart J. 2015 Aug 1;36(29):1901-12. doi: 10.1093/eurheartj/ehv116. Epub 2015 May 2.

Results Reference

derived

PubMed Identifier

25818495

Citation

Kholaif N, Zheng Y, Jagasia P, Himmelmann A, James SK, Steg PG, Storey RF, Westerhout CM, Armstrong PW. Baseline Q waves and time from symptom onset to ST-segment elevation myocardial infarction: insights from PLATO on the influence of sex. Am J Med. 2015 Aug;128(8):914.e11-9. doi: 10.1016/j.amjmed.2015.03.005. Epub 2015 Mar 26.

Results Reference

derived

PubMed Identifier

25660925

Citation

Cowper PA, Pan W, Anstrom KJ, Kaul P, Wallentin L, Davidson-Ray L, Nikolic E, Janzon M, Levin LA, Cannon CP, Harrington RA, Mark DB. Economic analysis of ticagrelor therapy from a U.S. perspective: results from the PLATO study. J Am Coll Cardiol. 2015 Feb 10;65(5):465-76. doi: 10.1016/j.jacc.2014.11.034.

Results Reference

derived

PubMed Identifier

25227704

Citation

Janzon M, James S, Cannon CP, Storey RF, Mellstrom C, Nicolau JC, Wallentin L, Henriksson M. Health economic analysis of ticagrelor in patients with acute coronary syndromes intended for non-invasive therapy. Heart. 2015 Jan;101(2):119-25. doi: 10.1136/heartjnl-2014-305864. Epub 2014 Sep 16.

Results Reference

derived

PubMed Identifier

24957530

Citation

Varenhorst C, Alstrom U, Braun OO, Storey RF, Mahaffey KW, Bertilsson M, Cannon CP, Scirica BM, Himmelmann A, James SK, Wallentin L, Held C. Causes of mortality with ticagrelor compared with clopidogrel in acute coronary syndromes. Heart. 2014 Nov;100(22):1762-9. doi: 10.1136/heartjnl-2014-305619. Epub 2014 Jun 23.

Results Reference

derived

PubMed Identifier

24952862

Citation

Kotsia A, Brilakis ES, Held C, Cannon C, Steg GP, Meier B, Cools F, Claeys MJ, Cornel JH, Aylward P, Lewis BS, Weaver D, Brandrup-Wognsen G, Stevens SR, Himmelmann A, Wallentin L, James SK. Extent of coronary artery disease and outcomes after ticagrelor administration in patients with an acute coronary syndrome: Insights from the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J. 2014 Jul;168(1):68-75.e2. doi: 10.1016/j.ahj.2014.04.001. Epub 2014 Apr 13.

Results Reference

derived

PubMed Identifier

24830710

Citation

Patel MR, Becker RC, Wojdyla DM, Emanuelsson H, Hiatt WR, Horrow J, Husted S, Mahaffey KW, Steg PG, Storey RF, Wallentin L, James SK. Cardiovascular events in acute coronary syndrome patients with peripheral arterial disease treated with ticagrelor compared with clopidogrel: Data from the PLATO Trial. Eur J Prev Cardiol. 2015 Jun;22(6):734-42. doi: 10.1177/2047487314533215. Epub 2014 May 15.

Results Reference

derived

PubMed Identifier

24682844

Citation

Husted S, James SK, Bach RG, Becker RC, Budaj A, Heras M, Himmelmann A, Horrow J, Katus HA, Lassila R, Morais J, Nicolau JC, Steg PG, Storey RF, Wojdyla D, Wallentin L; PLATO study group. The efficacy of ticagrelor is maintained in women with acute coronary syndromes participating in the prospective, randomized, PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J. 2014 Jun 14;35(23):1541-50. doi: 10.1093/eurheartj/ehu075. Epub 2014 Mar 28.

Results Reference

derived

PubMed Identifier

24561148

Citation

Mahaffey KW, Held C, Wojdyla DM, James SK, Katus HA, Husted S, Steg PG, Cannon CP, Becker RC, Storey RF, Khurmi NS, Nicolau JC, Yu CM, Ardissino D, Budaj A, Morais J, Montgomery D, Himmelmann A, Harrington RA, Wallentin L; PLATO Investigators. Ticagrelor effects on myocardial infarction and the impact of event adjudication in the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol. 2014 Apr 22;63(15):1493-9. doi: 10.1016/j.jacc.2014.01.038. Epub 2014 Feb 19.

Results Reference

derived

PubMed Identifier

24170388

Citation

Wallentin L, Lindholm D, Siegbahn A, Wernroth L, Becker RC, Cannon CP, Cornel JH, Himmelmann A, Giannitsis E, Harrington RA, Held C, Husted S, Katus HA, Mahaffey KW, Steg PG, Storey RF, James SK; PLATO study group. Biomarkers in relation to the effects of ticagrelor in comparison with clopidogrel in non-ST-elevation acute coronary syndrome patients managed with or without in-hospital revascularization: a substudy from the Prospective Randomized Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2014 Jan 21;129(3):293-303. doi: 10.1161/CIRCULATIONAHA.113.004420. Epub 2013 Oct 29.

Results Reference

derived

PubMed Identifier

24016496

Citation

Brilakis ES, Held C, Meier B, Cools F, Claeys MJ, Cornel JH, Aylward P, Lewis BS, Weaver D, Brandrup-Wognsen G, Stevens SR, Himmelmann A, Wallentin L, James SK. Effect of ticagrelor on the outcomes of patients with prior coronary artery bypass graft surgery: insights from the PLATelet inhibition and patient outcomes (PLATO) trial. Am Heart J. 2013 Sep;166(3):474-80. doi: 10.1016/j.ahj.2013.06.019. Epub 2013 Jul 26.

Results Reference

derived

PubMed Identifier

23900047

Citation

Steg PG, Harrington RA, Emanuelsson H, Katus HA, Mahaffey KW, Meier B, Storey RF, Wojdyla DM, Lewis BS, Maurer G, Wallentin L, James SK; PLATO Study Group. Stent thrombosis with ticagrelor versus clopidogrel in patients with acute coronary syndromes: an analysis from the prospective, randomized PLATO trial. Circulation. 2013 Sep 3;128(10):1055-65. doi: 10.1161/CIRCULATIONAHA.113.002589. Epub 2013 Jul 30.

Results Reference

derived

PubMed Identifier

23866179

Citation

Kunadian V, James SK, Wojdyla DM, Zorkun C, Wu J, Storey RF, Steg PG, Katus H, Emanuelsson H, Horrow J, Maya J, Wallentin L, Harrington RA, Gibson CM. Angiographic outcomes in the PLATO Trial (Platelet Inhibition and Patient Outcomes). JACC Cardiovasc Interv. 2013 Jul;6(7):671-83. doi: 10.1016/j.jcin.2013.03.014.

Results Reference

derived

PubMed Identifier

23800556

Citation

James SK, Storey RF, Pieper KS, Cannon CP, Becker RC, Steg PG, Wallentin L, Harrington RA; PLATO Study Group. Response to letter regarding article, "Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials". Stroke. 2013 Aug;44(8):e95-6. doi: 10.1161/STROKEAHA.113.002069. Epub 2013 Jun 25. No abstract available.

Results Reference

derived

PubMed Identifier

23572474

Citation

James SK, Pieper KS, Cannon CP, Storey RF, Becker RC, Steg PG, Wallentin L, Harrington RA; PLATO study group. Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials. Stroke. 2013 May;44(5):1477-9. doi: 10.1161/STROKEAHA.111.000514. Epub 2013 Apr 9. No abstract available.

Results Reference

derived

PubMed Identifier

23277305

Citation

Kohli P, Wallentin L, Reyes E, Horrow J, Husted S, Angiolillo DJ, Ardissino D, Maurer G, Morais J, Nicolau JC, Oto A, Storey RF, James SK, Cannon CP. Reduction in first and recurrent cardiovascular events with ticagrelor compared with clopidogrel in the PLATO Study. Circulation. 2013 Feb 12;127(6):673-80. doi: 10.1161/CIRCULATIONAHA.112.124248. Epub 2012 Dec 31.

Results Reference

derived

PubMed Identifier

23137503

Citation

Akerblom A, Wallentin L, Siegbahn A, Becker RC, Budaj A, Horrow J, Husted S, Katus H, Claeys MJ, Storey RF, Asenblad N, James SK. Outcome and causes of renal deterioration evaluated by serial cystatin C measurements in acute coronary syndrome patients -- results from the PLATelet inhibition and patient Outcomes (PLATO) study. Am Heart J. 2012 Nov;164(5):728-34. doi: 10.1016/j.ahj.2012.08.017. Epub 2012 Oct 17.

Results Reference

derived

PubMed Identifier

23021325

Citation

Varenhorst C, Alstrom U, Scirica BM, Hogue CW, Asenblad N, Storey RF, Steg PG, Horrow J, Mahaffey KW, Becker RC, James S, Cannon CP, Brandrup-Wognsen G, Wallentin L, Held C. Factors contributing to the lower mortality with ticagrelor compared with clopidogrel in patients undergoing coronary artery bypass surgery. J Am Coll Cardiol. 2012 Oct 23;60(17):1623-30. doi: 10.1016/j.jacc.2012.07.021. Epub 2012 Sep 26.

Results Reference

derived

PubMed Identifier

22991347

Citation

Husted S, James S, Becker RC, Horrow J, Katus H, Storey RF, Cannon CP, Heras M, Lopes RD, Morais J, Mahaffey KW, Bach RG, Wojdyla D, Wallentin L; PLATO study group. Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial. Circ Cardiovasc Qual Outcomes. 2012 Sep 1;5(5):680-8. doi: 10.1161/CIRCOUTCOMES.111.964395.

Results Reference

derived

PubMed Identifier

22980299

Citation

Cornel JH, Becker RC, Goodman SG, Husted S, Katus H, Santoso A, Steg G, Storey RF, Vintila M, Sun JL, Horrow J, Wallentin L, Harrington R, James S. Prior smoking status, clinical outcomes, and the comparison of ticagrelor with clopidogrel in acute coronary syndromes-insights from the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J. 2012 Sep;164(3):334-342.e1. doi: 10.1016/j.ahj.2012.06.005. Epub 2012 Jul 26.

Results Reference

derived

PubMed Identifier

22719022

Citation

Nikolic E, Janzon M, Hauch O, Wallentin L, Henriksson M; PLATO Health Economic Substudy Group. Cost-effectiveness of treating acute coronary syndrome patients with ticagrelor for 12 months: results from the PLATO study. Eur Heart J. 2013 Jan;34(3):220-8. doi: 10.1093/eurheartj/ehs149. Epub 2012 Jun 19.

Results Reference

derived

PubMed Identifier

22572911

Citation

James SK, Storey RF, Khurmi NS, Husted S, Keltai M, Mahaffey KW, Maya J, Morais J, Lopes RD, Nicolau JC, Pais P, Raev D, Lopez-Sendon JL, Stevens SR, Becker RC; PLATO Study Group. Ticagrelor versus clopidogrel in patients with acute coronary syndromes and a history of stroke or transient ischemic attack. Circulation. 2012 Jun 12;125(23):2914-21. doi: 10.1161/CIRCULATIONAHA.111.082727. Epub 2012 May 9.

Results Reference

derived

PubMed Identifier

22546885

Citation

Siha H, Das D, Fu Y, Zheng Y, Westerhout CM, Storey RF, James S, Wallentin L, Armstrong PW. Baseline Q waves as a prognostic modulator in patients with ST-segment elevation: insights from the PLATO trial. CMAJ. 2012 Jul 10;184(10):1135-42. doi: 10.1503/cmaj.111683. Epub 2012 Apr 30.

Results Reference

derived

PubMed Identifier

22261200

Citation

Goodman SG, Clare R, Pieper KS, Nicolau JC, Storey RF, Cantor WJ, Mahaffey KW, Angiolillo DJ, Husted S, Cannon CP, James SK, Kilhamn J, Steg PG, Harrington RA, Wallentin L; Platelet Inhibition and Patient Outcomes Trial Investigators. Association of proton pump inhibitor use on cardiovascular outcomes with clopidogrel and ticagrelor: insights from the platelet inhibition and patient outcomes trial. Circulation. 2012 Feb 28;125(8):978-86. doi: 10.1161/CIRCULATIONAHA.111.032912. Epub 2012 Jan 18.

Results Reference

derived

PubMed Identifier

22179530

Citation

Armstrong PW, Siha H, Fu Y, Westerhout CM, Steg PG, James SK, Storey RF, Horrow J, Katus H, Clemmensen P, Harrington RA, Wallentin L. ST-elevation acute coronary syndromes in the Platelet Inhibition and Patient Outcomes (PLATO) trial: insights from the ECG substudy. Circulation. 2012 Jan 24;125(3):514-21. doi: 10.1161/CIRCULATIONAHA.111.047530. Epub 2011 Dec 16.

Results Reference

derived

PubMed Identifier

22090660

Citation

Becker RC, Bassand JP, Budaj A, Wojdyla DM, James SK, Cornel JH, French J, Held C, Horrow J, Husted S, Lopez-Sendon J, Lassila R, Mahaffey KW, Storey RF, Harrington RA, Wallentin L. Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J. 2011 Dec;32(23):2933-44. doi: 10.1093/eurheartj/ehr422. Epub 2011 Nov 16. Erratum In: Eur Heart J. 2012 Nov;33(21):2750.

Results Reference

derived

PubMed Identifier

21709065

Citation

Mahaffey KW, Wojdyla DM, Carroll K, Becker RC, Storey RF, Angiolillo DJ, Held C, Cannon CP, James S, Pieper KS, Horrow J, Harrington RA, Wallentin L; PLATO Investigators. Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2011 Aug 2;124(5):544-54. doi: 10.1161/CIRCULATIONAHA.111.047498. Epub 2011 Jun 27.

Results Reference

derived

PubMed Identifier

21685437

Citation

James SK, Roe MT, Cannon CP, Cornel JH, Horrow J, Husted S, Katus H, Morais J, Steg PG, Storey RF, Stevens S, Wallentin L, Harrington RA; PLATO Study Group. Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial. BMJ. 2011 Jun 17;342:d3527. doi: 10.1136/bmj.d3527.

Results Reference

derived

PubMed Identifier

21545948

Citation

Scirica BM, Cannon CP, Emanuelsson H, Michelson EL, Harrington RA, Husted S, James S, Katus H, Pais P, Raev D, Spinar J, Steg PG, Storey RF, Wallentin L; PLATO Investigators. The incidence of bradyarrhythmias and clinical bradyarrhythmic events in patients with acute coronary syndromes treated with ticagrelor or clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) trial: results of the continuous electrocardiographic assessment substudy. J Am Coll Cardiol. 2011 May 10;57(19):1908-16. doi: 10.1016/j.jacc.2010.11.056.

Results Reference

derived

PubMed Identifier

21060072

Citation

Steg PG, James S, Harrington RA, Ardissino D, Becker RC, Cannon CP, Emanuelsson H, Finkelstein A, Husted S, Katus H, Kilhamn J, Olofsson S, Storey RF, Weaver WD, Wallentin L; PLATO Study Group. Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation. 2010 Nov 23;122(21):2131-41. doi: 10.1161/CIRCULATIONAHA.109.927582. Epub 2010 Nov 8.

Results Reference

derived

PubMed Identifier

20805430

Citation

James S, Budaj A, Aylward P, Buck KK, Cannon CP, Cornel JH, Harrington RA, Horrow J, Katus H, Keltai M, Lewis BS, Parikh K, Storey RF, Szummer K, Wojdyla D, Wallentin L. Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2010 Sep 14;122(11):1056-67. doi: 10.1161/CIRCULATIONAHA.109.933796. Epub 2010 Aug 30.

Results Reference

derived

PubMed Identifier

20079528

Citation

Cannon CP, Harrington RA, James S, Ardissino D, Becker RC, Emanuelsson H, Husted S, Katus H, Keltai M, Khurmi NS, Kontny F, Lewis BS, Steg PG, Storey RF, Wojdyla D, Wallentin L; PLATelet inhibition and patient Outcomes Investigators. Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet. 2010 Jan 23;375(9711):283-93. doi: 10.1016/S0140-6736(09)62191-7. Epub 2010 Jan 13.

Results Reference

derived

PubMed Identifier

19717846

Citation

Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, Horrow J, Husted S, James S, Katus H, Mahaffey KW, Scirica BM, Skene A, Steg PG, Storey RF, Harrington RA; PLATO Investigators; Freij A, Thorsen M. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009 Sep 10;361(11):1045-57. doi: 10.1056/NEJMoa0904327. Epub 2009 Aug 30.

Results Reference

derived

PubMed Identifier

17637939

Citation

Molecule of the month. Ticagrelor. Drug News Perspect. 2007 May;20(4):264. No abstract available.

Results Reference

derived

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A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome

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A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome (PLATO)

Acute Coronary Syndrome

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