Imaging the Effects of Bihemispheric Transcranial Stimulation and Motor Training After Stroke.
Stroke

About this trial
This is an interventional treatment trial for Stroke focused on measuring Stroke Rehabilitation, Transcranial Direct Current Stimulation, Neuroimaging, Neuronal Plasticity
Eligibility Criteria
Inclusion Criteria:
- Chronic Stroke (> 12 months)
- Upper limb sensorimotor sequelae due to stroke affecting only one cerebral hemisphere
- The structural integrity of the corpus callosum sensorimotor
- Showing ability to perform some movement with the paretic upper limb: at least minimal active mobility of the wrist and two fingers of the paretic hand.
- Score ≥ 18 at Folstein Mini-Mental State Examination
Exclusion Criteria:
- Score ≥ 4 at Ashworth Scale
- MRI or tDCS contraindications (cardiac pacemakers; implanted medication pumps; cochlear, or eye implants; craniotomy, skin lesions at the site of stimulation; surgical clips in or near the brain; claustrophobia, history of seizures, permanent makeup or tattoos with metallic dyes…)
- Prior neurological diseases
- Hemodynamic instability
- Pregnancy
- Traumatic or orthopedic lesion limiting the range of upper limb motion
- Severe comprehension deficits, apraxia or neglect that would interfere with performing the study tasks
- Score > 59 at the Fugl-Meyer Assessment of Motor Recovery after Stroke
Sites / Locations
- D'Or Institute for Research and Education (IDOR)Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
tDCS
Control
Bihemispheric tDCS will be applied. The anode will be placed on the affected hemisphere, while the cathode will be positioned over the unaffected hemisphere. After stimulation, individual and intensive upper limb rehabilitation will be performed.
Bihemispheric sham tDCS will be applied. The anode will be placed on the affected hemisphere, while the cathode will be positioned over the unaffected hemisphere. After sham stimulation, individual and intensive upper limb rehabilitation will be performed.