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Active clinical trials for "Immune System Diseases"

Results 37801-37810 of 37852

Analysis of Transcriptomic Profile of Graft-versus-host Disease (GHVD) After Allogeneic Grafting...

Graft Vs Host DiseaseHematopoietic Stem Cells

Graft-versus-host disease (GVHD) is a frequent and severe complication of hematopoietic stem cell transplantation (HSC), and is responsible for significant early mortality despite prophylactic strategies developed in recent decades, Especially since it is resistant to first-line treatment. The present diagnosis is difficult, non-specific and is based on the combination of an evocative clinical context (CSH allograft, time to appearance before J100, characteristic clinical manifestations), suggestive anatomo-pathological analysis (predominantly inflammatory infiltrate Lymphocyte, mucosal edema and presence of apoptotic bodies), and the exclusion of any differential diagnosis (in particular serology / negative viral PCR). However, to date there is no molecular characterization of this manifestation, and therefore no specific treatment. The nCounter® nanostring technology allows the rapid and simple analysis of the simultaneous expression of a group of genes (up to 800 on the same sample), from a very small amount of RNA, and from samples with difficulty Such as fabrics already fixed to formaldehyde and included in paraffin. It allows the detection of a "molecular signature" of the tissue analyzed. No transcriptomic analysis has ever been performed on human tissues with GVHD.

Unknown status9 enrollment criteria

Developing a Functional Cure for HIV Disease: Clinical Specimen Collection From HIV Positive Individuals...

HIV Infections

Clinical specimens are required from HIV positive individuals with viremia controlled by antiretroviral therapy to complete process development for a genetically modified autologous T cell product, AGT103-T. The product will be used in a subsequent early stage clinical trial in subjects with chronic HIV disease and viremia suppressed by antiretroviral therapy as the initial step in testing a functional cure for HIV disease. Enrolled participants provide a venous blood specimen (approximately 25mL) to determine their level of HIV-reactive CD4+ T cells. Subjects with positive T cell responses will be asked to undergo leukapheresis and their clinical specimens will be used to validate and qualify the AGT103-T cell product.

Unknown status38 enrollment criteria

Systemic Lupus and Adverse Pregnancy Outcome

Systemic Lupus ErythematosusPregnancy Complications

prospective analytical study of all pregnant ladies with systemic lupus in Beni-suef localities

Unknown status3 enrollment criteria

Thyroid Autoimmunity and Reproductive Failure in Danish Women

ThyroidInfertility3 more

The present Ph.D.-study investigates the mechanisms behind the association between thyroid autoimmunity and reproductive failure.

Unknown status2 enrollment criteria

Measuring and Predicting Glycemic Response to Food in Patients With Type 1 Diabetes

Personalized Medicine in Type 1 Diabetes

Personalized medicine methods in the management of type 1 diabetes

Unknown status2 enrollment criteria

Collection of Additional Data Followed the Study IFM 2013-04

Myeloma Multiple

Collection of retrospective additional data (survival, biological, disease response data) following the study IFM 2013-04.

Unknown status35 enrollment criteria

Post-transplant Cyclophosphamide in Wiskott-Aldrich Syndrome

Wiskott-Aldrich Syndrome

A protocol named as "CIP-2015" for patients with Wiskott-Aldrich Syndrome may reduce the rate of GvHD. The details of the protocal followed with: Conditioning regimen Busulfan 16 mg/kg in total, Fludarabine 160 mg/m2 in total. GvHD Prophylaxis: Rabbit antihuman thymocyte globulin 7.5 mg/kg post-transplant cyclophosphamide (CY) (50 mg/kg.d on days +3 and +4) Cyclosporine or tacrolimus, mycophenolate mofetil, on days +5

Unknown status2 enrollment criteria

Consequences of DNA Repair and Telomere Defects on the Function of the Immune System: Application...

Immune Deficiency and Early BMF in Childhood

The molecular mechanisms participating in the various aspects of the DNA Damage Response (DDR) are absolutely essential to maintain the genome dynamics essential to all living organisms. The most commonly studied consequence of faulty DDR is genome instability participating in cancer onset. In the present proposal, we wish to explore another aspect of DDR, not relevant to cancer, which is its absolute requirement at several key steps of the development, maturation, and function of the immune system. The most "spectacular" consequences of faulty DNA repair processes with respect to the immuno-hematopoietic tissue are the complete block of B and T lymphocytes maturation owing to defective DNA joining phase during V(D)J recombination resulting in patients with Severe Combined Immune Deficiency (SCID). The objectives of this study are to increase our knowledge on the role of the various DNA repair processes in the development, the maintenance, and the function of the immune system and thus, to better understand why and how dysfunctions of these DNA repair processes result in human severe conditions such as CVID, LOCID or other manifestations of immune disorders such as autoimmunity. The explorations of DNA repair mechanisms in the patients will allow us to establish the genetic diagnosis in some patients with until now undefined molecular diagnosis. This is of immediate importance for the patients and their families, as it not only contributes to a better understanding of the patients' condition, but also allows providing genetic counseling for the families.

Unknown status4 enrollment criteria

The I-Score Study: Developing a New Patient-Reported Tool for the Routine HIV Care of Patients on...

HIV/AIDS

The purpose of this Canada-France study is to develop and validate a multidimensional patient-reported measure of perceived barriers to antiretroviral therapy adherence for HIV-positive patients undergoing treatment that will be theoretically founded, easy to use and helpful to clinicians in their medical decision-making, in a clinical or research setting.

Unknown status11 enrollment criteria

Use of Immunosuppressive Therapy for Sarcoidosis

Sarcoidosis

Retrospective review of the outcome of use of immunosuppressive drugs in treatment of sarcoidosis

Unknown status2 enrollment criteria
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