Long-Term Lithium Treatment for Aggressive Conduct Disorder
Conduct Disorder, Aggression
About this trial
This is an interventional treatment trial for Conduct Disorder focused on measuring Aggressive conduct disorder, Adolescence, Child, Conduct Disorder, Female, Lithium, Male, Placebos, Conduct Disorder -- *drug therapy, Lithium -- *therapeutic use
Eligibility Criteria
Inclusion Criteria: Males and females Ages between 9 and 17 years. Conduct disorder according to DSM-IV (As rated on the DICA-IV). The aggression criterion at screening Exclusion Criteria: Mental Retardation. Pervasive Developmental Disorder(s). Major Depressive Disorder or Dysthymic Disorder. Bipolar Disorder. Psychotic Disorder (including Schizophreniform Disorder and Schizophrenia). Major medical problem such as cardiac, renal, and thyroid diseases, or seizure disorder. History of psychoactive medication in the previous 2 weeks. Current Pregnancy in females. History of Substance Dependence in the past month. Prior to the proposed study, a history of lithium treatment with serum lithium levels of 0.4 mEq/L or higher for a cumulative period of greater than 10 days.
Sites / Locations
- Drexel University College of Medicine at Friends Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
1
2
Lithium 600 mg to 2700 mg per day
Matching placebo