Antifolate Effectiveness in Arthritis
Rheumatoid Arthritis, Adjuvant Arthritis
About this trial
This is an interventional diagnostic trial for Rheumatoid Arthritis focused on measuring Rheumatoid arthritis, Lewis rat adjuvant arthritis, Antifolate efficacy, Autoimmunity, Adenosine metabolism, Methotrexate therapy, Skeletal disorder, Dietary supplement, Antiarthritic agent, Folic acid
Eligibility Criteria
Inclusion Criteria: Individuals starting methotrexate for rheumatoid arthritis. Study subjects should not currently be taking folic acid-containing vitamins. Exclusion Criteria: Cancer, renal, or liver disease. Previous use of methotrexate within the past 6 months or current use of folic acid-containing supplements.
Sites / Locations
- The University of Alabama at Birmingham
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Group 1 - Folinic acid
Group 2: Folic acid
Subjects receiving Methotrexate for 6 weeks and 5 mg of Folinic acid daily for 1 week.
Subjects receiving Methotrexate for 6 weeks and 5 mg of Folic acid daily for 1 week.