Naltrexone Treatment for Alcoholism
Alcoholism
About this trial
This is an interventional treatment trial for Alcoholism
Eligibility Criteria
Inclusion Criteria: Meets criteria for alcohol dependence. Committed to alcohol abstinence as a treatment goal. Individuals will be required to identify two family members or close friends who are knowledgeable about their location, drinking behavior, and psychosocial status. Exclusion Criteria: Meets criteria for any other psychoactive substance use disorder (excluding nicotine and caffeine). Meets criteria for a major psychiatric disorder and are in need of or currently undergoing pharmacotherapy. Females who are pregnant, lactating, or not using a reliable method of contraception. Currently experiencing a serious medical condition that would place them at risk or interfere with study participation. Experiencing acute hepatitis or liver failure or whose liver function test is more than 3 times normal. Have a history of severe allergies, multiple adverse drug reactions or known allergy to naltrexone. Vocabulary below the 5th grade reading level. Abnormal MRI scan. HIV infection due to the neurological sequelae. Significant central nervous system diseases. Seizure disorder or history of closed head trauma. Neuroendocrine disorders. Treatment with opiates within the last six months.
Sites / Locations
- Johns Hopkins Hospital