Drug Treatment for Alcoholics With Post-Traumatic Stress Disorder

Inclusion Criteria: Meets criteria for alcohol abuse or dependence and post-traumatic stress disorder. Laboratory tests for blood and urinalysis must be within normal limits. Must be clearly motivated to obtain benefit from treatment and keep appointments for study visits and therapy sessions. Females who use an acceptable method of birth control, are sterilized, or are at least 2 years post-menopausal. Exclusion Criteria: Have a diagnosis of schizophrenia, bipolar affective disorder, dissociative identity disorder, eating disorder, substance dependence in the last 60 days. Currently suicidal. Medical reasons not to receive drug therapy. Allergy or hypersensitivity to selective serotonin inhibitor antidepressants. Significant hematological, endocrine, cardiovascular, renal, hepatic, neurological, or gastrointestinal disease. Liver function test greater than 2 times the normal level Require ongoing therapy with another psychoactive drug during the study period. Females who are pregnant or lactating.