Enhancing Recovery in Coronary Heart Disease (ENRICHD) Patients
Primary Purpose
Cardiovascular Diseases, Coronary Disease, Depression
Status
Completed
Phase
Phase 3
Locations
Study Type
Interventional
Intervention
social support
Sponsored by
About this trial
This is an interventional prevention trial for Cardiovascular Diseases
Eligibility Criteria
Men and women coronary heart disease/myocardial infarction patients, hospitalized for enzyme-documented MI and who are depressed and/or have low social support. Patients must be enrolled with 28 days of the index MI.
Sites / Locations
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
NCT ID
NCT00000557
First Posted
October 27, 1999
Last Updated
April 12, 2016
Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
1. Study Identification
Unique Protocol Identification Number
NCT00000557
Brief Title
Enhancing Recovery in Coronary Heart Disease (ENRICHD) Patients
Study Type
Interventional
2. Study Status
Record Verification Date
January 2008
Overall Recruitment Status
Completed
Study Start Date
September 1995 (undefined)
Primary Completion Date
September 2005 (Actual)
Study Completion Date
September 2005 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
4. Oversight
5. Study Description
Brief Summary
To evaluate the effect of psychosocial intervention on mortality and reinfarction in coronary heart disease patients at high psychosocial risk.
Detailed Description
BACKGROUND:
As medical treatments for coronary heart disease have become more sophisticated, they have also become more costly. Evidence concerning the effects of medical and rehabilitative therapies on post-myocardial infarction patients' quality of life, including return to work and to normal levels of functioning, has been mixed. At the same time. recent data suggest that psychosocial factors, such as social isolation and depression, are important predictors of morbidity and mortality in coronary heart disease patients. These studies suggest that interventions which provide psychological support to myocardial infarction patients may enhance both the psychosocial and physical recovery of these patients. To the extent that supportive interventions can be shown to impact favorably on survival and health-related quality of life in myocardial infarction patients, the human and financial costs associated with coronary heart disease can be reduced. The initiative originated in the Working Group on Psychosocial Interventions which met in June 1992.
The initiative was given concept clearance by the October 1993 National Heart, Lung, and Blood Advisory Council. The Request for Proposals was released in September 1994.
DESIGN NARRATIVE:
The study design compared a psychosocial intervention group, in which patients were provided with social and psychological treatment designed to decrease social isolation and depression, with a standard medical care group. The combined endpoint was death and reinfarction, measured for up to 4.5 years following hospital discharge. Secondary endpoints included assessment of health quality of life (HQL).
The protocol was approved in May 1996. Recruitment began in October 1996 and ended on October 31, 1999 with 2,481 patients enrolled.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cardiovascular Diseases, Coronary Disease, Depression, Heart Diseases, Myocardial Infarction, Myocardial Ischemia
7. Study Design
Primary Purpose
Prevention
Study Phase
Phase 3
8. Arms, Groups, and Interventions
Intervention Type
Behavioral
Intervention Name(s)
social support
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Men and women coronary heart disease/myocardial infarction patients, hospitalized for enzyme-documented MI and who are depressed and/or have low social support. Patients must be enrolled with 28 days of the index MI.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Diane Catellier
Organizational Affiliation
University of North Carolina
12. IPD Sharing Statement
Citations:
PubMed Identifier
10618555
Citation
Enhancing recovery in coronary heart disease patients (ENRICHD): study design and methods. The ENRICHD investigators. Am Heart J. 2000 Jan;139(1 Pt 1):1-9. doi: 10.1016/s0002-8703(00)90301-6.
Results Reference
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PubMed Identifier
9392958
Citation
Blumenthal JA, O'Connor C, Hinderliter A, Fath K, Hegde SB, Miller G, Puma J, Sessions W, Sheps D, Zakhary B, Williams RB. Psychosocial factors and coronary disease. A national multicenter clinical trial (ENRICHD) with a North Carolina focus. N C Med J. 1997 Nov-Dec;58(6):440-4.
Results Reference
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PubMed Identifier
11472719
Citation
ENRICHD Investigators. Enhancing recovery in coronary heart disease (ENRICHD): baseline characteristics. Am J Cardiol. 2001 Aug 1;88(3):316-22. doi: 10.1016/s0002-9149(01)01652-6. No abstract available.
Results Reference
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PubMed Identifier
11767809
Citation
Mendes de Leon CF, Dilillo V, Czajkowski S, Norten J, Schaefer J, Catellier D, Blumenthal JA; Enhancing Recovery in Coronary Heart Disease (ENRICHD) Pilot Study. Psychosocial characteristics after acute myocardial infarction: the ENRICHD pilot study. Enhancing Recovery in Coronary Heart Disease. J Cardiopulm Rehabil. 2001 Nov-Dec;21(6):353-62. doi: 10.1097/00008483-200111000-00003.
Results Reference
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PubMed Identifier
11573023
Citation
ENRICHD Investigators. Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design. Psychosom Med. 2001 Sep-Oct;63(5):747-55.
Results Reference
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PubMed Identifier
12461195
Citation
Freedland KE, Skala JA, Carney RM, Raczynski JM, Taylor CB, Mendes de Leon CF, Ironson G, Youngblood ME, Krishnan KR, Veith RC. The Depression Interview and Structured Hamilton (DISH): rationale, development, characteristics, and clinical validity. Psychosom Med. 2002 Nov-Dec;64(6):897-905. doi: 10.1097/01.psy.0000028826.64279.29.
Results Reference
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PubMed Identifier
12851607
Citation
Watkins LL, Schneiderman N, Blumenthal JA, Sheps DS, Catellier D, Taylor CB, Freedland KE; ENRICHD Investigators. Cognitive and somatic symptoms of depression are associated with medical comorbidity in patients after acute myocardial infarction. Am Heart J. 2003 Jul;146(1):48-54. doi: 10.1016/S0002-8703(03)00083-8.
Results Reference
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PubMed Identifier
12813116
Citation
Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, Czajkowski SM, DeBusk R, Hosking J, Jaffe A, Kaufmann PG, Mitchell P, Norman J, Powell LH, Raczynski JM, Schneiderman N; Enhancing Recovery in Coronary Heart Disease Patients Investigators (ENRICHD). Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. JAMA. 2003 Jun 18;289(23):3106-16. doi: 10.1001/jama.289.23.3106.
Results Reference
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PubMed Identifier
14636903
Citation
Carney RM, Blumenthal JA, Catellier D, Freedland KE, Berkman LF, Watkins LL, Czajkowski SM, Hayano J, Jaffe AS. Depression as a risk factor for mortality after acute myocardial infarction. Am J Cardiol. 2003 Dec 1;92(11):1277-81. doi: 10.1016/j.amjcard.2003.08.007.
Results Reference
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PubMed Identifier
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Citation
Barefoot JC, Burg MM, Carney RM, Cornell CE, Czajkowski SM, Freedland KE, Hosking JD, Khatri P, Pitula CR, Sheps D. Aspects of social support associated with depression at hospitalization and follow-up assessment among cardiac patients. J Cardiopulm Rehabil. 2003 Nov-Dec;23(6):404-12. doi: 10.1097/00008483-200311000-00002.
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PubMed Identifier
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Citation
Mitchell PH, Powell L, Blumenthal J, Norten J, Ironson G, Pitula CR, Froelicher ES, Czajkowski S, Youngblood M, Huber M, Berkman LF. A short social support measure for patients recovering from myocardial infarction: the ENRICHD Social Support Inventory. J Cardiopulm Rehabil. 2003 Nov-Dec;23(6):398-403. doi: 10.1097/00008483-200311000-00001. No abstract available.
Results Reference
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PubMed Identifier
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Citation
Froelicher ES, Miller NH, Buzaitis A, Pfenninger P, Misuraco A, Jordan S, Ginter S, Robinson E, Sherwood J, Wadley V. The Enhancing Recovery in Coronary Heart Disease Trial (ENRICHD): strategies and techniques for enhancing retention of patients with acute myocardial infarction and depression or social isolation. J Cardiopulm Rehabil. 2003 Jul-Aug;23(4):269-80. doi: 10.1097/00008483-200307000-00004.
Results Reference
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PubMed Identifier
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Citation
Blumenthal JA, Babyak MA, Carney RM, Huber M, Saab PG, Burg MM, Sheps D, Powell L, Taylor CB, Kaufmann PG. Exercise, depression, and mortality after myocardial infarction in the ENRICHD trial. Med Sci Sports Exerc. 2004 May;36(5):746-55. doi: 10.1249/01.mss.0000125997.63493.13.
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PubMed Identifier
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Results Reference
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PubMed Identifier
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Citation
Carney RM, Blumenthal JA, Freedland KE, Youngblood M, Veith RC, Burg MM, Cornell C, Saab PG, Kaufmann PG, Czajkowski SM, Jaffe AS; ENRICHD Investigators. Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study. Psychosom Med. 2004 Jul-Aug;66(4):466-74. doi: 10.1097/01.psy.0000133362.75075.a6.
Results Reference
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PubMed Identifier
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Citation
Vaglio J Jr, Conard M, Poston WS, O'Keefe J, Haddock CK, House J, Spertus JA. Testing the performance of the ENRICHD Social Support Instrument in cardiac patients. Health Qual Life Outcomes. 2004 May 13;2:24. doi: 10.1186/1477-7525-2-24.
Results Reference
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PubMed Identifier
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Citation
Powell LH, Catellier D, Freedland KE, Burg MM, Woods SL, Bittner V, Calvin JE, Blumenthal JA; ENRICHD Investigators. Depression and heart failure in patients with a new myocardial infarction. Am Heart J. 2005 May;149(5):851-5. doi: 10.1016/j.ahj.2004.08.007.
Results Reference
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PubMed Identifier
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Citation
Carney RM, Blumenthal JA, Freedland KE, Stein PK, Howells WB, Berkman LF, Watkins LL, Czajkowski SM, Hayano J, Domitrovich PP, Jaffe AS. Low heart rate variability and the effect of depression on post-myocardial infarction mortality. Arch Intern Med. 2005 Jul 11;165(13):1486-91. doi: 10.1001/archinte.165.13.1486.
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Citation
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Citation
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Results Reference
background
Available IPD and Supporting Information:
Available IPD/Information Type
Individual Participant Data Set
Available IPD/Information URL
http://biolincc.nhlbi.nih.gov/studies/enrichd/
Available IPD/Information Identifier
ENRICHD
Available IPD/Information Comments
NHLBI provides controlled access to IPD through BioLINCC. Access requires registration, evidence of local IRB approval or certification of exemption from IRB review, and completion of a data use agreement.
Available IPD/Information Type
Study Protocol
Available IPD/Information URL
http://biolincc.nhlbi.nih.gov/studies/enrichd/
Available IPD/Information Type
Manual of Procedures
Available IPD/Information URL
http://biolincc.nhlbi.nih.gov/studies/enrichd/
Learn more about this trial
Enhancing Recovery in Coronary Heart Disease (ENRICHD) Patients
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