Chemotherapy and Azidothymidine, With or Without Radiotherapy, for High Grade Lymphoma in AIDS-Risk Group Members
Lymphoma, Non-Hodgkin, HIV Infections
About this trial
This is an interventional treatment trial for Lymphoma, Non-Hodgkin focused on measuring Vincristine, Lymphoma, Methotrexate, Cyclophosphamide, Cytarabine, Dexamethasone, Doxorubicin, Drug Therapy, Combination, Combined Modality Therapy, Acquired Immunodeficiency Syndrome, Antineoplastic Agents, Combined, Zidovudine, Bleomycin
Eligibility Criteria
Inclusion Criteria Concurrent Medication: Allowed: Ibuprofen. Standard antiemetic agents. Ganciclovir therapy for sight- or life-threatening Cytomegalovirus infection. Zidovudine and methotrexate may be resumed during ganciclovir maintenance phase. Exclusion Criteria Co-existing Condition: The following patients will be excluded from the study: Patients with recurrent infection that may interfere with the planned protocol. Patients with a second active tumor other than nonmelanomatous skin cancer or Kaposi's sarcoma. Patients with stage IE primary central nervous system lymphoma. Concurrent Medication: Excluded: Corticosteroids. Aspirin. Acetaminophen. Nonsteroidal anti-inflammatory drugs, except ibuprofen. Chemotherapy for infection associated with neutropenia. Zidovudine (AZT) for infection associated with neutropenia. Investigational therapies, except ganciclovir therapy for sight- or life-threatening cytomegalovirus infection. AZT and methotrexate will be suspended during induction therapy with ganciclovir. The following patients will be excluded from the study: Patients with recurrent infection that may interfere with the planned protocol. Patients with a second active tumor other than nonmelanomatous skin cancer or Kaposi's sarcoma. Patients with stage IE primary central nervous system lymphoma. Prior Medication: Excluded: Zidovudine (AZT). Excluded within 2 weeks of study entry: Immunomodulating agents. Antiretroviral therapy prior to diagnosis of lymphoma. Patients must demonstrate the following clinical and laboratory findings: Any stage of the disease, including stage I. Newly diagnosed, previously untreated high-grade lymphoma. Presence of measurable tumor parameter(s). Adequate hepatic, renal, and bone marrow function.
Sites / Locations
- Los Angeles County - USC Med Ctr
- UCLA CARE Ctr
- San Francisco AIDS Clinic / San Francisco Gen Hosp
- George Washington Univ Med Ctr
- Charity Hosp / Tulane Univ Med School
- Louisiana State Univ Med Ctr / Tulane Med School
- Tulane Univ School of Medicine
- Univ of Massachusetts Med Ctr
- Bellevue Hosp / New York Univ Med Ctr
- Saint Luke's - Roosevelt Hosp Ctr
- Mount Sinai Med Ctr
- Univ of Rochester Medical Center
- Milton S Hershey Med Ctr
- Julio Arroyo