Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis Carinii Pneumonia in Pediatric HIV Infection
Pneumonia, Pneumocystis Carinii, HIV Infections
About this trial
This is an interventional treatment trial for Pneumonia, Pneumocystis Carinii focused on measuring Pneumonia, Pneumocystis carinii, Dapsone, Acquired Immunodeficiency Syndrome, AIDS-Related Complex, Drug Administration Schedule
Eligibility Criteria
Inclusion Criteria Concurrent Medication: Allowed: Rifampin and rifampin derivatives for up to 1 week during the study. Rifabutin or other drugs that could alter dapsone metabolism (if prescribed by the child's primary care physician). Patients must have: Evidence of HIV infection. PER AMENDMENT 11/16/95: Children who require prophylaxis. (Was written - Risk of developing PCP.) Known intolerance to TMP / SMX. Consent of parent or guardian. Patients entering this study may be co-enrolled in other ACTG pediatric studies. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: Glucose-6-phosphate dehydrogenase deficiency. Known allergy to dapsone. Concurrent Medication: Excluded: Rifampin, rifampin derivatives, or oxidant drugs for more than 1 week. Patients with the following prior conditions are excluded: Serious or life-threatening reactions to TMP / SMX (e.g., anaphylaxis, Stevens-Johnson syndrome, hypotension) that would contraindicate therapy with sulfa drugs. Prior Medication: Excluded: Prior dapsone. Rifampin, rifampin derivatives, or oxidant drugs within 1 week prior to study entry. TMP / SMX within 7 days prior to study entry (and toxicity must be clearly resolving). Prior Treatment: Excluded: RBC transfusion within 4 weeks prior to study entry.
Sites / Locations
- Long Beach Memorial Med. Ctr., Miller Children's Hosp.
- Usc La Nichd Crs
- UCLA-Los Angeles/Brazil AIDS Consortium (LABAC) CRS
- Children's Hosp. & Research Ctr. Oakland, Ped. Clinical Research Ctr. & Research Lab.
- UCSD Maternal, Child, and Adolescent HIV CRS
- Harbor - UCLA Med. Ctr. - Dept. of Peds., Div. of Infectious Diseases
- Univ. of Colorado Denver NICHD CRS
- Children's National Med. Ctr., ACTU
- Howard Univ. Washington DC NICHD CRS
- Univ. of Florida Jacksonville NICHD CRS
- Univ. of Miami Ped. Perinatal HIV/AIDS CRS
- Emory Univ. School of Medicine, Dept. of Peds., Div. of Infectious Diseases
- Cook County Hosp.
- Chicago Children's CRS
- Univ. of Chicago - Dept. of Peds., Div. of Infectious Disease
- Univ. of Illinois College of Medicine at Chicago, Dept. of Peds
- Tulane/LSU Maternal/Child CRS
- HMS - Children's Hosp. Boston, Div. of Infectious Diseases
- BMC, Div. of Ped Infectious Diseases
- Baystate Health, Baystate Med. Ctr.
- WNE Maternal Pediatric Adolescent AIDS CRS
- Children's Hospital of Michigan NICHD CRS
- UMDNJ - Robert Wood Johnson
- St. Joseph's Hosp. & Med. Ctr. of New Jersey
- SUNY Downstate Med. Ctr., Children's Hosp. at Downstate NICHD CRS
- North Shore-Long Island Jewish Health System, Dept. of Peds.
- Schneider Children's Hosp., Div. of Infectious Diseases
- NYU Med. Ctr., Dept. of Medicine
- Columbia IMPAACT CRS
- Incarnation Children's Ctr.
- Harlem Hosp. Ctr. NY NICHD CRS
- Univ. of Rochester ACTG CRS
- Strong Memorial Hospital Rochester NY NICHD CRS
- SUNY Stony Brook NICHD CRS
- SUNY Upstate Med. Univ., Dept. of Peds.
- DUMC Ped. CRS
- Case CRS
- The Children's Hosp. of Philadelphia IMPAACT CRS
- St. Christopher's Hosp. for Children
- Med. Univ. of South Carolina, Div. of Ped. Infectious Diseases
- St. Jude/UTHSC CRS
- Childrens Hosp. of the Kings Daughters
- UW School of Medicine - CHRMC
- Univ. Hosp. Ramón Ruiz Arnau, Dept. of Peds
- San Juan City Hosp. PR NICHD CRS
- Univ. of Puerto Rico Ped. HIV/AIDS Research Program CRS