A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
Pneumonia, Pneumocystis Carinii, HIV Infections
About this trial
This is an interventional treatment trial for Pneumonia, Pneumocystis Carinii focused on measuring Pneumonia, Pneumocystis carinii, Dapsone, Antifungal Agents, Acquired Immunodeficiency Syndrome, atovaquone
Eligibility Criteria
Inclusion Criteria Concurrent Medication: Strongly recommended: Pyrimethamine (50 mg) and folinic acid (15 mg) weekly in patients receiving dapsone who have CD4 count < 100 cells/mm3 and are toxoplasmosis seropositive. Patients must have: Working diagnosis of HIV infection. CD4 count <= 200 cells/mm3 or <= 15 percent of total lymphocyte count at any time in the past OR a history of PCP. History of intolerance of trimethoprim and/or sulfonamides that required permanent discontinuation. NOTE: Pregnant patients are eligible at the clinician's discretion. Prior Medication: Allowed: Prior PCP prophylaxis. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Active pneumocystosis. Concurrent Medication: Excluded: PCP prophylaxis (other than study drug) or any medication with potential anti-PCP activity. Patients with the following prior conditions are excluded: Known treatment-limiting reaction to dapsone or atovaquone.
Sites / Locations
- Alabama Therapeutics CRS
- USC CRS
- Stanford CRS
- Ucsd, Avrc Crs
- Ucsf Aids Crs
- Santa Clara Valley Med. Ctr.
- San Mateo County AIDS Program
- Harbor-UCLA Med. Ctr. CRS
- University of Colorado Hospital CRS
- Howard University Hosp., Div. of Infectious Diseases, ACTU
- Univ. of Miami AIDS CRS
- Emory Univ. Hemophilia Program Office
- Queens Med. Ctr.
- Univ. of Hawaii at Manoa, Leahi Hosp.
- Northwestern University CRS
- Cook County Hosp. CORE Ctr.
- Rush Univ. Med. Ctr. ACTG CRS
- Weiss Memorial Hosp.
- Indiana Univ. School of Medicine, Infectious Disease Research Clinic
- Univ. of Iowa Healthcare, Div. of Infectious Diseases
- Johns Hopkins Adult AIDS CRS
- Bmc Actg Crs
- Beth Israel Deaconess - East Campus A0102 CRS
- Massachusetts General Hospital ACTG CRS
- Hennepin County Med. Ctr., Div. of Infectious Diseases
- University of Minnesota, ACTU
- St. Louis ConnectCare, Infectious Diseases Clinic
- Washington U CRS
- Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr.
- SUNY - Buffalo, Erie County Medical Ctr.
- Beth Israel Med. Ctr. (Mt. Sinai)
- NY Univ. HIV/AIDS CRS
- Univ. of Rochester ACTG CRS
- Unc Aids Crs
- Carolinas HealthCare System, Carolinas Med. Ctr.
- Regional Center for Infectious Disease, Wendover Medical Center CRS
- Wake County Health and Human Services CRS
- Univ. of Cincinnati CRS
- Case CRS
- MetroHealth CRS
- The Ohio State Univ. AIDS CRS
- Hosp. of the Univ. of Pennsylvania CRS
- University of Washington AIDS CRS
- Mbeya Med. Research Program, Mbeya Referral Hosp. CRS