Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Didanosine, Drug Therapy, Combination, Acquired Immunodeficiency Syndrome, AIDS-Related Complex, Antiviral Agents, Zidovudine, Stavudine, Lamivudine
Eligibility Criteria
Inclusion Criteria Concurrent Medication: Allowed: PCP prophylaxis. Patients must have: HIV infection. CD4 count 200 - 600 cells/mm3. Life expectancy of at least 24 weeks. Consent of parent or guardian if less than 18 years old. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Unexplained temperature >= 38.5 C for 7 consecutive days within 30 days prior to study entry. PER AMENDMENT 1/25/96: A malignancy that requires systemic chemotherapies other than Kaposi's sarcoma. Concurrent Medication: Excluded: Concurrent other antiretroviral or immunologic agents. Other experimental therapies. Systemic corticosteroids (except as adjuvant therapy for acute PCP) and other immunosuppressive drugs. Systemic cytotoxic chemotherapy. Induction or maintenance with foscarnet or ganciclovir (oral or IV). Patients with the following prior conditions are excluded: History of acute or chronic pancreatitis. History of grade 2 or higher peripheral neuropathy. Prior Medication: Excluded: Antiretrovirals within 90 days prior to study entry. More than 7 days total lifetime use of any antiretroviral nucleoside.
Sites / Locations
- Alabama Therapeutics CRS
- UCLA CARE Center CRS
- Stanford CRS
- Ucsd, Avrc Crs
- Santa Clara Valley Med. Ctr.
- San Mateo County AIDS Program
- University of Colorado Hospital CRS
- Univ. of Miami AIDS CRS
- Queens Med. Ctr.
- Univ. of Hawaii at Manoa, Leahi Hosp.
- Cook County Hosp. CORE Ctr.
- Rush Univ. Med. Ctr. ACTG CRS
- Weiss Memorial Hosp.
- Northwestern University CRS
- Indiana Univ. School of Medicine, Infectious Disease Research Clinic
- Methodist Hosp. of Indiana
- Johns Hopkins Adult AIDS CRS
- Beth Israel Deaconess Med. Ctr., ACTG CRS
- St. Louis ConnectCare, Infectious Diseases Clinic
- Washington U CRS
- SUNY - Buffalo, Erie County Medical Ctr.
- Beth Israel Med. Ctr. (Mt. Sinai)
- NYU Med. Ctr., Dept. of Medicine
- Univ. of Rochester ACTG CRS
- Unc Aids Crs
- Carolinas HealthCare System, Carolinas Med. Ctr.
- Regional Center for Infectious Disease, Wendover Medical Center CRS
- MetroHealth CRS
- The Ohio State University Medical Center
- Hosp. of the Univ. of Pennsylvania CRS
- University of Washington AIDS CRS
- Puerto Rico-AIDS CRS