A Study to Compare the Effectiveness of Different Anti-HIV Drug Regimens in Keeping Levels of HIV in the Blood as Low as Possible
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Didanosine, Drug Therapy, Combination, Stavudine, HIV Protease Inhibitors, Hydroxyurea, RNA, Viral, Reverse Transcriptase Inhibitors, Anti-HIV Agents, Viral Load, efavirenz
Eligibility Criteria
Inclusion Criteria You may be eligible for this study if you: Are at least 13 years old (need consent if under 18). Are HIV-positive. Are taking your first anti-HIV drug regimen, which must include a PI and at least one NRTI (nucleoside reverse transcriptase inhibitor) and have been on this regimen for at least 12 months. Have a viral load less than 400 copies/ml for at least 12 months prior to study entry, and have a viral load less than 50 copies/ml within 60 days of study entry. Have a CD4 cell count of at least 200 cells/mm3 within 60 days of study entry. Are willing to go back on the drugs you are currently on, if necessary. Are willing to use effective methods of birth control during the study and for 3 months after. Exclusion Criteria You will not be eligible for this study if you: Have taken ddI, d4T, or HU for more than 2 weeks. Have taken any NNRTI (non-nucleoside reverse transcriptase inhibitor) for more than 7 days. Have ever taken EFV. Have received an HIV vaccine within 30 days prior to study entry. Have an AIDS-related cancer that requires chemotherapy. Have or have had pancreatic disease. Are being treated for a significant illness. Abuse drugs or alcohol. Are pregnant or breast-feeding. Are allergic to any study drugs. Have received certain medications.
Sites / Locations
- Willow Clinic
- Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium
- San Mateo AIDS Program / Stanford Univ
- Stanford Univ Med Ctr
- Univ of Miami School of Medicine
- Indiana Univ Hosp
- Division of Inf Diseases/ Indiana Univ Hosp
- Methodist Hosp of Indiana / Life Care Clinic
- Harvard (Massachusetts Gen Hosp)
- Beth Israel Deaconess - West Campus
- Beth Israel Med Ctr
- Bellevue Hosp / New York Univ Med Ctr
- Chelsea Ctr
- Cornell Univ Med Ctr
- Univ of Rochester Medical Center
- Univ of North Carolina
- Univ of Cincinnati
- Ohio State Univ Hosp Clinic
- Univ of Pennsylvania at Philadelphia