Study of a New Anti-HIV Drug, T-20, in HIV-Infected Children
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Injections, Intravenous, Injections, Subcutaneous, Drug Therapy, Combination, HIV Protease Inhibitors, Membrane Fusion, Reverse Transcriptase Inhibitors, Anti-HIV Agents, Viral Load, peptide T20
Eligibility Criteria
Inclusion Criteria Children may be eligible for this study if they: Are 3 to 12 years old (consent of parent or guardian required). Are HIV-positive. Are receiving combination anti-HIV therapy. He/she must have been taking this combination for at least 16 weeks, and it must include either 2 NRTIs alone or 2 NRTIs plus either an NNRTI or a PI. (This study has been changed. This no longer has to be a child's first anti-HIV drug combination.) Have a viral load greater than 10,000 copies/ml while taking this anti-HIV drug combination. Have never received treatment with a PI or an NNRTI. (One or two doses are allowed.) Have never taken at least 1 NRTI. Exclusion Criteria Children will not be eligible for this study if they: Are receiving treatment for an opportunistic (AIDS-related) or serious bacterial infection at the time of study entry. Are receiving chemotherapy for cancer. Have certain serious diseases (other than HIV) or conditions. Have received or are currently receiving certain medications. Are pregnant.
Sites / Locations
- UCSD Med Ctr / Pediatrics / Clinical Sciences
- Long Beach Memorial (Pediatric)
- Children's Hosp of Los Angeles/UCLA Med Ctr
- UCSF / Moffitt Hosp - Pediatric
- Children's Hosp of Washington DC
- Howard Univ Hosp
- Univ of Florida Health Science Ctr / Pediatrics
- Univ of Miami (Pediatric)
- Tulane Univ / Charity Hosp of New Orleans
- Children's Hosp of Boston
- Boston City Hosp / Pediatrics
- Baystate Med Ctr of Springfield
- Univ of Massachusetts Med School
- Children's Hosp of Michigan
- Univ of Medicine & Dentistry of New Jersey / Univ Hosp
- Bronx Lebanon Hosp Ctr
- Bronx Municipal Hosp Ctr/Jacobi Med Ctr
- North Shore Univ Hosp
- Bellevue Hosp / New York Univ Med Ctr
- Metropolitan Hosp Ctr
- Harlem Hosp Ctr
- SUNY Health Sciences Ctr at Syracuse / Pediatrics
- Duke Univ Med Ctr
- Med Univ of South Carolina
- San Juan City Hosp