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PET Scan to Study Brain Control of Human Movement

Primary Purpose

Ataxia, Cerebrovascular Accident, Healthy

Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
National Institute of Neurological Disorders and Stroke (NINDS)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Ataxia focused on measuring Ataxia, Brain, Motor Learning, Parkinson's Disease, Physiology, Positron Emission Tomography, Stroke, Tremor, Voluntary and Involuntary Movement Physiology, Movement Disorders, Normal Volunteer

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

Patients with movement disorder and normal volunteers.

Sites / Locations

  • National Institute of Neurological Disorders and Stroke (NINDS)

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
November 3, 1999
Last Updated
March 15, 2021
Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
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1. Study Identification

Unique Protocol Identification Number
NCT00001324
Brief Title
PET Scan to Study Brain Control of Human Movement
Official Title
CNS Control of Human Movement: H215O PET Studies
Study Type
Observational

2. Study Status

Record Verification Date
March 2000
Overall Recruitment Status
Completed
Study Start Date
March 1992 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
July 2001 (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)

4. Oversight

5. Study Description

Brief Summary
Positron Emission Tomography (PET) is a technique used to investigate activity in areas of the brain. The PET technique allows researchers to study the normal processes in the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases, blood flow to and from the area of activity also increases. This is known as regional cerebral blood flow (rCBF). Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow. In this study researchers plan to investigate the changes in regional cerebral blood flow (rCBF) as patients participate in different activities. The activities are designed to stimulate the areas of the brain responsible for voluntary motor activity and sensation. By comparing the results of PET scans performed in different conditions, researchers can locate regions of the brain responsible for specific tasks. This study should provide new information about voluntary movements in humans and the preparation involved in controlling them.
Detailed Description
The main purpose of the studies presented in this protocol is to investigate the physiology of motor control in health as well as the pathophysiological modifications taking place during disease. To this end, we will investigate changes in regional cerebral blood flow (rCBF) as an index of regional neuronal activity, associated with various motor and sensory tasks using Positron Emission Tomography (PET). The rCBF will be obtained by measuring the distribution of the cerebral radioactivity during emission scans following the intravenous bolus injection of 15O-labeled water. The very short half-life of 15O (2 minutes) allows us to measure rCBF repeatedly under different task conditions (see methodology and experimental procedures). With the comparison between PET scans performed in different conditions, we can detect the specific task-related activated regions. PET images will be coregistered to high resolution Magnetic Resonance Images (MRI) to get more accurate anatomical information regarding the activated areas. The results will be correlated with that from other physiological approaches including Electroencephalography (EEG), Transcranial Magnetic Stimulation (TMS), functional Magnetic Resonance Imaging (fMRI), and Magnetic Resonance Spectroscopy (MRS). These studies should provide new information not only about the executive component of the voluntary movements in humans but also the different organizational aspects of the preparatory processes that control them.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Ataxia, Cerebrovascular Accident, Healthy, Movement Disorder, Tremor
Keywords
Ataxia, Brain, Motor Learning, Parkinson's Disease, Physiology, Positron Emission Tomography, Stroke, Tremor, Voluntary and Involuntary Movement Physiology, Movement Disorders, Normal Volunteer

7. Study Design

Enrollment
510 (false)

10. Eligibility

Sex
All
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Patients with movement disorder and normal volunteers.
Facility Information:
Facility Name
National Institute of Neurological Disorders and Stroke (NINDS)
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
9571132
Citation
Deiber MP, Ibanez V, Honda M, Sadato N, Raman R, Hallett M. Cerebral processes related to visuomotor imagery and generation of simple finger movements studied with positron emission tomography. Neuroimage. 1998 Feb;7(2):73-85. doi: 10.1006/nimg.1997.0314.
Results Reference
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PubMed Identifier
9549504
Citation
Catalan MJ, Honda M, Weeks RA, Cohen LG, Hallett M. The functional neuroanatomy of simple and complex sequential finger movements: a PET study. Brain. 1998 Feb;121 ( Pt 2):253-64. doi: 10.1093/brain/121.2.253.
Results Reference
background
PubMed Identifier
9307128
Citation
Deiber MP, Wise SP, Honda M, Catalan MJ, Grafman J, Hallett M. Frontal and parietal networks for conditional motor learning: a positron emission tomography study. J Neurophysiol. 1997 Aug;78(2):977-91. doi: 10.1152/jn.1997.78.2.977.
Results Reference
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PET Scan to Study Brain Control of Human Movement

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