Study of Silicone-Associated Connective Tissue Diseases
Autoimmune Diseases, Connective Tissue Diseases, Scleroderma, Circumscribed
About this trial
This is an observational trial for Autoimmune Diseases focused on measuring Autoimmune Diseases, Connective Tissue Disease, Scleroderma, Silicone Device Implants, Silicone Injection, Idiopathic Scleroderma, Myositis, Systemic Sclerosis
Eligibility Criteria
For all groups: Age greater than 18 years; ability to give informed consent. Must not have severe medical disease requiring intensive care or any other conditions in which the drawing of the amount of blood required for research purposes is not deemed medically appropriate by the treating physician or the principal investigator. For Group 1: Patients who have had silicon prostheses, or silicone injection, who subsequently developed scleroderma/systemic sclerosis or myositis as defined by criteria established by the American College of Rheumatology. For Group 2: Patients with idiopathic scleroderma/systemic sclerosis or myositis as defined by criteria established by the American Collage of Rheumatology, without silicone implantation or injection, age-, sex-, and race-matched to Group 1. Group 3: Patients who have had silicone prostheses or silicone injection, age-, sex-, race- and silicone exposure-matched to patients in Group 1, who have not developed chronic symptoms, physical findings, or laboratory abnormalities associated with autoimmune or connective tissue diseases.
Sites / Locations
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)