Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)
Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder, Streptococcal Infection
About this trial
This is an interventional treatment trial for Mental Disorder Diagnosed in Childhood focused on measuring Obsessive Compulsive Disorder, PANDAS Associated with Streptococcal Infections, Adolescents, Autoimmune Illness, Children, Tic Disorders, Streptococcal Infections, Childhood Onset Neuropsychiatric Disorder
Eligibility Criteria
INCLUSION CRITERIA: Ages 4 - 18 years Fulfill criteria for membership in the PANDAS subgroup: Presence of OCD and/or tic disorder Prepubertal symptom onset Abrupt onset and episodic (relapsing-remitting) symptom course Association between symptom exacerbations and GABHS infections Presence of choreiform movements or other neurological abnormalities during symptom exacerbations. Because "time to relapse" is one of the primary outcome variables, children will not be eligible for randomization until their symptoms are in (at least partial) remission. At the time of randomization, symptom severity scores should be less than 50% of the child's previous maximum score on both the CY-BOCS and YGTSS, and no higher than a total score of 20 on the CY-BOCS or 30 on the YGTSS. EXCLUSION CRITERIA: Personal history of penicillin allergy History of rheumatic fever, including Sydenham's chorea Diagnosis of autism, schizophrenia or other psychotic disorder Chronic illnesses, particularly neurologic and immunologic disorders
Sites / Locations
- National Institute of Mental Health (NIMH)