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PET Scan to Map the Areas of the Brain Involved in Planning

Primary Purpose

Cognition Disorders

Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
National Institute of Neurological Disorders and Stroke (NINDS)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Cognition Disorders focused on measuring Blood Flow, Chess Play, Frontal Lobe, Neurobehavioral Deficits, Neuropsychology, Positron Emission Tomography, Prefrontal Cortex

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Normal Controls: Males and female subjects from two age ranges: 18-30 and 50-65 years of age. Individuals with a history of neurological or psychiatric disorder will not be included nor will individuals currently taking psychoactive medication. Patients: Patients with outstanding problems in planning. Patients must have a diagnosed CNS disorder with lesion localization verified by MRI scanning available from the referring physician or completed at the NIH Clinical Center. Patients with unilateral or bilateral lesions that meet the behavioral criteria for selection (planning disorder). Patients will be medication free (or taking medication with no known central nervous system effects) and be able to understand instructions and task demands.

Sites / Locations

  • National Institute of Neurological Disorders and Stroke (NINDS)

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
November 3, 1999
Last Updated
March 3, 2008
Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
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1. Study Identification

Unique Protocol Identification Number
NCT00001363
Brief Title
PET Scan to Map the Areas of the Brain Involved in Planning
Official Title
Functional Brain Mapping of Planning Activities With [015] Water PET Blood Flow Technique
Study Type
Observational

2. Study Status

Record Verification Date
May 2000
Overall Recruitment Status
Completed
Study Start Date
January 1993 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
March 2001 (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)

4. Oversight

5. Study Description

Brief Summary
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive water (H215O) and PET scans to observe what areas of the brain are receiving more blood flow. This study will attempt to determine the areas of the brain activated by planning processes and decision making. Researchers will ask patients to participate in tests and games (chess) that will stimulate the areas of the brain involved with decision making and planning while undergoing the water PET blood flow technique.
Detailed Description
This protocol will attempt to determine the topographical distribution in the brain of the cognitive components of planning using the [150] water PET blood flow technique. We will administer perception, motor, simple decision, and planning tasks using the game of chess and the Tower of Hanoi Test as paradigms. Utilizing a "subtraction technique" we hope to identify those areas of cerebral cortex which are most activated by planning processes. It is predicted that the dorsolateral frontal areas will be most prominently activated. It is also predicted that the essential components of the planning process will be the same regardless of the type of plans being executed. The data we collect will be of value in determining 1) the neural representation of planning processes and 2) in guiding cognitive models of the planning system.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cognition Disorders
Keywords
Blood Flow, Chess Play, Frontal Lobe, Neurobehavioral Deficits, Neuropsychology, Positron Emission Tomography, Prefrontal Cortex

7. Study Design

Enrollment
230 (false)

10. Eligibility

Sex
All
Accepts Healthy Volunteers
No
Eligibility Criteria
Normal Controls: Males and female subjects from two age ranges: 18-30 and 50-65 years of age. Individuals with a history of neurological or psychiatric disorder will not be included nor will individuals currently taking psychoactive medication. Patients: Patients with outstanding problems in planning. Patients must have a diagnosed CNS disorder with lesion localization verified by MRI scanning available from the referring physician or completed at the NIH Clinical Center. Patients with unilateral or bilateral lesions that meet the behavioral criteria for selection (planning disorder). Patients will be medication free (or taking medication with no known central nervous system effects) and be able to understand instructions and task demands.
Facility Information:
Facility Name
National Institute of Neurological Disorders and Stroke (NINDS)
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
8183339
Citation
Nichelli P, Grafman J, Pietrini P, Alway D, Carton JC, Miletich R. Brain activity in chess playing. Nature. 1994 May 19;369(6477):191. doi: 10.1038/369191a0. No abstract available.
Results Reference
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PubMed Identifier
8733740
Citation
Partiot A, Grafman J, Sadato N, Flitman S, Wild K. Brain activation during script event processing. Neuroreport. 1996 Feb 29;7(3):761-6. doi: 10.1097/00001756-199602290-00020.
Results Reference
background
PubMed Identifier
9106270
Citation
Flitman S, O'Grady J, Cooper V, Grafman J. PET imaging of maze processing. Neuropsychologia. 1997 Apr;35(4):409-20. doi: 10.1016/s0028-3932(96)00086-3.
Results Reference
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PET Scan to Map the Areas of the Brain Involved in Planning

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