Active Immunization of Sibling Bone Marrow Transplant Donors Against Purified Myeloma Protein of the Recipient Undergoing Allogeneic Bone Marrow Transplantation

INCLUSION CRITERIA: Patient Selection: Patients with IgG or IgA multiple myeloma who attain at least a PR before transplantation are eligible for thsi protocol. Patients may only have received 3-4 courses of VAD, high dose cyclophosphamide and one autologous transplant before entering the study. All previous therapy must be completed at least 2 weeks prior to study entry. Patients should have recovered from all hematologic and non-hematologic toxicity of previous therapy. Steroid must be discontinued at least two weeks prior to vaccination. Only patients less than 60 years are eligible for this protocol. Patients must meet the following criteria: A. Karnofsky performance status greater than or equal to 70 percent. B. Life expectancy greater than 8 weeks and absence of co-existing medical problems which would significantly increase the risk of the transplant procedure in the judgment of the bone marrow transplant attending physicians (e.g., the MUGA left ventricular ejection fraction has to be greater than 50% and DLCO greater thant 50% of the expected value when corrected for Hb). Creatinine less than 2x normal and not rising for at least 2-4 weeks before transplantation. If creatinine is elevated, then creatinine clearance must be greater than 40 ml/min. Direct bilirubin less than 2 mg/dl, SGOT less than 4x top normal, and none of these parameters increasing, for at least 2-4 weeks before transplantation. Patients must be HIV-negative, HBsAg-, and Hepatitis C antibody Negative. Not pregnant or lactating. Patients of childbearing potential must use an effective method of contraception. M-protein concentration in the harvested plasma must be greater than 90 percent of the total Ig of the corresponding isotype. Patients must be greater than or equal to 18 years old. Donor criteria: Any consenting healthy individual who fulfills the donor criteria will be considered for the marrow donation. HLA-identical sibling donors. HLA, A and B and DR phenotypically identical family donors. HIV, hepatitis B or C seropositive. Complete blood count, platelets, and PT, PTT within normal limits.