A Three-Arm Comparative Trial for the Treatment of MAC Bacteremia in AIDS: A Clarithromycin/Ethambutol Regimen Containing Rifabutin (450 Mg) or Rifabutin (300 Mg) or Placebo
Mycobacterium Avium-Intracellulare Infection, HIV Infections
About this trial
This is an interventional treatment trial for Mycobacterium Avium-Intracellulare Infection focused on measuring Rifabutin, Mycobacterium avium-intracellulare Infection, Drug Therapy, Combination, Ethambutol, Acquired Immunodeficiency Syndrome, Clarithromycin
Eligibility Criteria
Inclusion Criteria Concurrent Medication: Allowed: Isoniazid for TB prophylaxis ONLY. Patients must have: HIV infection. MAC infection. Life expectancy of at least 16 weeks. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Perceived unreliability or unavailability for frequent monitoring. Concurrent Medication: Excluded: Antimycobacterial drugs other than the study drugs. Carbamazepine. Terfenadine. Theophylline. Patients with the following prior condition are excluded: History of hypersensitivity to rifabutin, rifampin, erythromycin, clarithromycin, azithromycin, or ethambutol. Prior Medication: Excluded within 7 days prior to study entry: Rifabutin. Rifampin. Ethionamide. Cycloserine. Clofazimine. Ethambutol. Amikacin. Ciprofloxacin. Ofloxacin. Sparfloxacin. Azithromycin. Clarithromycin. Pyrazinamide. Excluded within 14 days prior to study entry: Carbamazepine. Terfenadine. Theophylline.
Sites / Locations
- McDowell Clinic
- Maricopa Med Research Foundation
- Bay Harbor Hosp
- Ctr for Special Immunology
- Combat Group
- Cedars Sinai Med Ctr
- Highland Gen Hosp / San Francisco Gen Hosp
- HIV Research Group
- UCSD / Ctr for Special Immunology
- Saint Francis Mem Hosp
- San Francisco Veterans Administration Med Ctr
- Sunnyvale Med Clinic
- George Washington Univ Med Ctr
- Veterans Administration Med Ctr
- Infectious Disease Consultants
- TheraFirst Med Ctrs Inc
- Dr Frank Tornaka
- Gary Richmond MD
- Dr Nelson Zide
- Ctr for Special Immunology
- Dr Barry Rodwick
- Bay Area AIDS Consortium
- Infectious Disease Research Consortium of Georgia
- Dr Daniel Berger
- Univ of Kansas School of Medicine
- Tulane Univ Med School
- Dr Arnold Markowitz
- Univ of Nebraska Med Ctr / HIV Clinic
- East Orange Veterans Administration Med Ctr
- North Jersey Community Research Initiative
- Long Island Jewish Med Ctr
- Chelsea Village Med Ctr / Saint Vincent's Hosp
- Community Health Network
- Nalle Clinic
- Polyclinic Med Ctr
- Buckley Braffman Stern Med Associates
- Charleston Veterans Administration Med Ctr
- Dr Alfred F Burnside Jr
- Central Texas Med Foundation
- Houston Veterans Administration Med Ctr
- Univ TX San Antonio Health Science Ctr
- Infectious Disease Physicians Inc
- Univ of Wisconsin School of Medicine
- Milwaukee County Med Complex