Photodynamic Therapy Clinical Trial For Cutaneous AIDS-Related Kaposi's Sarcoma Study Summary.
Sarcoma, Kaposi, HIV Infections
About this trial
This is an interventional treatment trial for Sarcoma, Kaposi focused on measuring Skin Neoplasms, Sarcoma, Kaposi, Acquired Immunodeficiency Syndrome, Photochemotherapy, tin etiopurpurin, Radiation-Sensitizing Agents
Eligibility Criteria
Inclusion Criteria Patients must have: Documentation of at least one biopsy-confirmed KS lesion. A minimum of 4 and no more than 36 KS lesions. All eligible lesions must be bidimensionally measurable, treatable by surface (non-contact) light illumination, and <= 40 mm in diameter of the longest bidimensional axis. ACTG disease state T(0) L(0) or (1) S(0) or (1). Life expectancy greater than 6 months. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: Active opportunistic infection or condition except thrush or herpes simplex virus infections. Advanced KS tumor stages including the presence of tumor associated edema or ulceration, extensive oral KS, or KS in other non-nodal viscera. Hematopoietic dysfunction. Coagulation dysfunction. Hepatic dysfunction. Renal dysfunction. Cardiovascular dysfunction - Presence of significant coronary artery disease requiring current treatment or myocardial infarction. Pulmonary dysfunction. Sepsis. Known disorder of lipoprotein metabolism or clearance. Patients with the following prior conditions are excluded: History of allergic or hypersensitivity reactions to light, egg proteins or egg yolks, history of porphyria, systemic lupus erythematosus or xeroderma pigmentosum. Excluded within 7 days of therapy: Hematopoietic dysfunction. Coagulation dysfunction. Hepatic dysfunction. Renal dysfunction. Excluded within 3 months of therapy: Pulmonary dysfunction. Excluded within 6 months of therapy: Myocardial infarction. Prior Medication: Excluded: Intralesional chemotherapy within the past 12 weeks. Systemic chemotherapy or investigational drugs within the past 4 weeks. Prior Treatment: Excluded within 3 months prior to therapy: Local cryotherapy or surgery to study lesions. Systemic or topical photodynamic therapy agents.
Sites / Locations
- Univ of Southern California / Los Angeles
- Cedars Sinai Med Ctr
- Univ of California / San Francisco / Dermatology
- Health One - Rocky Mountain Cancer Ctr
- Buffalo Gen Hosp / PDT Ctr
- Thompson Cancer Survival Ctr