A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the Eyes

Inclusion Criteria Patients must have: AIDS. Clinical diagnosis of previously untreated peripheral CMV retinitis in one eye. Leading edge of a CMV retinitis lesion is at least 750 microns from zone one. NOTE: Patients with CMV retinitis in zone three only may be eligible if the lesions can be reliably photographed to follow progression. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions in the eye to be treated are excluded: External ocular infections. Other herpetic infections of the retina, toxoplasma retinochoroiditis, or other disease of the fundus. Ocular conditions that will obstruct visualization of the posterior ocular structures. Retinal detachment. Silicone oil in eye. Patients with the following other symptoms or conditions are excluded: Known or suspected allergy to phosphorothioate oligonucleotides. Syphilis. Pseudoretinitis pigmentosa. Concurrent Medication: Excluded: Current treatment for extra-ocular CMV infection. Ganciclovir. Foscarnet. Mellaril. Stelazine. Thorazine. Clofazimine. Ethambutol/fluconazole combination. Investigational medications for CMV retinitis. Concurrent Treatment: Excluded: Investigational procedures for CMV retinitis. Patients with the following prior conditions are excluded: History of surgery to correct retinal detachment in the eye to be treated. History of syphilis. Prior Medication: Excluded: Prior anti-CMV retinitis treatment in either eye. Anti-CMV therapy for extra-ocular infection within the past 2 days.