Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Cancer of the Uterus
Sarcoma
About this trial
This is an interventional treatment trial for Sarcoma focused on measuring stage I uterine sarcoma, stage II uterine sarcoma, stage III uterine sarcoma, stage IV uterine sarcoma, uterine carcinosarcoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed primary homologous or heterologous carcinosarcoma of the uterus (corpus and cervix) Surgical stage I-IV disease, including positive adnexa, tumor invading the serosa, positive pelvic and/or para-aortic nodes, involvement of the mucosa of the bowel, bladder, or rectum, intra-abdominal metastases, positive pelvic washings, or vaginal involvement within planned radiation port Prior total abdominal hysterectomy with bilateral salpingo-oophorectomy and maximum tumor resection of all gross intra-abdominal/pelvic disease, including grossly involved pelvic and para-aortic nodes within 8 weeks before study No greater than 1 cm residual disease Cervical sarcomas also allowed No metastasis beyond the abdominal cavity at diagnosis, including the following: Parenchymal liver metastasis Lung metastasis Positive inguinal lymph nodes Positive scalene nodes Radiographic or pathologic evidence of bone or brain metastasis PATIENT CHARACTERISTICS: Age: 21 and over Performance status: GOG 0-2 Hematopoietic: WBC at least 3,000/mm3 Granulocyte count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 times normal SGOT no greater than 3 times normal Albumin at least 3 g/dL No acute hepatitis Renal: Creatinine no greater than 1.5 mg/dL OR Creatinine clearance at least 50 mL/min Other: No septicemia No severe infection No severe gastrointestinal bleeding No prior invasive or concurrent malignancy within the past 5 years except nonmelanoma skin cancer PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Prior hormonal therapy allowed Radiotherapy: See Disease Characteristics No prior radiotherapy Surgery: See Disease Characteristics Other: No prior therapy that would preclude study therapy
Sites / Locations
- University of Alabama at Birmingham Comprehensive Cancer Center
- CCOP - Western Regional, Arizona
- Women's Cancer Center - Los Gatos
- Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
- University of Colorado Cancer Center at University of Colorado Health Sciences Center
- CCOP - Christiana Care Health Services
- Walter Reed Army Medical Center
- University of Miami Sylvester Comprehensive Cancer Center
- Rush University Medical Center
- MBCCOP - University of Illinois at Chicago
- University of Chicago Cancer Research Center
- CCOP - Central Illinois
- CCOP - Evanston
- CCOP - Carle Cancer Center
- Indiana University Cancer Center
- CCOP - Northern Indiana CR Consortium
- Saint Joseph Regional Medical Center
- Holden Comprehensive Cancer Center at University of Iowa
- Cancer Center at Tufts - New England Medical Center
- UMASS Memorial Cancer Center - University Campus
- CCOP - Michigan Cancer Research Consortium
- Barbara Ann Karmanos Cancer Institute
- CCOP - Grand Rapids
- CCOP - Kalamazoo
- University of Minnesota Cancer Center
- CCOP - Metro-Minnesota
- University of Mississippi Medical Center
- Keesler Medical Center - Keesler Air Force Base
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- CCOP - Kansas City
- Siteman Cancer Center at Barnes-Jewish Hospital
- CCOP - Cancer Research for the Ozarks
- CCOP - Missouri Valley Cancer Consortium
- CCOP - Southern Nevada Cancer Research Foundation
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- Cancer Institute of New Jersey at the Cooper University Hospital
- MBCCOP - University of New Mexico HSC
- Memorial Sloan-Kettering Cancer Center
- Long Island Cancer Center at Stony Brook University Hospital
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
- Duke Comprehensive Cancer Center
- Gynecologic Oncology Network
- Comprehensive Cancer Center at Wake Forest University
- Charles M. Barrett Cancer Center at University Hospital
- MetroHealth's Cancer Care Center at MetroHealth Medical Center
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
- University of Oklahoma College of Medicine
- CCOP - Columbia River Oncology Program
- Abington Memorial Hospital
- CCOP - Geisinger Clinic and Medical Center
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Abramson Cancer Center at the University of Pennsylvania
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Fox Chase Cancer Center
- UPMC Cancer Center at Magee-Womens Hospital
- Southeast Gynecologic Oncology Associates
- Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center
- University of Texas Medical Branch
- CCOP - Scott and White Hospital
- Fletcher Allen Health Care - Medical Center Hospital of Vermont Campus
- Cancer Center at the University of Virginia
- Fred Hutchinson Cancer Research Center
- MultiCare Regional Cancer Center at Tacoma General Hospital
- Pretoria Academic Hospital