Lymphocyte Therapy in Treating Patients With Kidney Cancer
Kidney Cancer
About this trial
This is an interventional treatment trial for Kidney Cancer focused on measuring stage III renal cell cancer, stage IV renal cell cancer, recurrent renal cell cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically documented and completely resected stage III or stage IV renal cell carcinoma, clinically staged within 2 months prior to initiation of therapy No evidence of nephrotic syndrome PATIENT CHARACTERISTICS: Age: Over 16 Performance status: ECOG 0-2 Hematopoietic: WBC at least 3,000/mm^3 Granulocyte count at least 1,500/mm^3 Platelet count 50,000/mm3 to 500,000/mm^3 Hemoglobin at least 10 g/dL No hematologic abnormalities Hepatic: PT no greater than 1.5 times control PTT less than 1.5 times control Hepatitis B surface antigen negative Renal: Creatinine no greater than 4.0 mg/dL Calcium no greater than 12 mg/dL No symptomatic hypercalcemia Cardiovascular: No uncontrolled or severe cardiac disease, e.g.: No myocardial infarction within 6 months No congestive heart failure Other: HIV negative No significant organ dysfunction No other serious medical illness that would limit life expectancy No significant CNS disease including uncontrolled or untreated psychiatric or seizure disorders No uncontrolled bacterial, viral, or fungal infection No active peptic or duodenal ulcer Adequate peripheral venous access required No prior malignancy within past 5 years except inactive nonmelanoma skin cancer or carcinoma in situ of the cervix Not pregnant Negative pregnancy test PRIOR CONCURRENT THERAPY: No other concurrent postnephrectomy adjuvant therapy Biologic therapy: No concurrent immunotherapy Chemotherapy: No concurrent chemotherapy Endocrine therapy: More than 1 week since prior corticosteroids (except as inhalation therapy for respiratory ailments or replacement for adrenal insufficiency) No concurrent therapy with the following: Estrogens (except as postmenopausal replacement therapy) Androgens Progestins Antiestrogens Antiandrogens LHRH analogues or antagonists Other hormones Radiotherapy: Not specified Surgery: See Disease Characteristics No prior solid organ allograft More than 3 weeks since major surgery, including nephrectomy
Sites / Locations
- Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center