Lymph Node Radiation Therapy in Patients With Stage I, Stage II, or Stage III Breast Cancer That Has Been Surgically Removed
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring stage I breast cancer, stage II breast cancer, stage IIIA breast cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed unilateral adenocarcinoma of the breast Stage I/II/III (Tx, T0-3, N0-2) disease in one of the following categories or multifocal tumors if one of the foci is in agreement with the following: Centrally or medially located with any lymph node status Central location defined as underlying the areola Medial location defined as at least partial involvement of upper or lower medial quadrant of breast Externally located with axillary node involvement Prior mastectomy or breast-conserving surgery and axillary dissection required Sentinel node procedure as axillary intervention without further axillary surgery is allowed No prior internal mammary chain dissection No upper inner lesion treated with breast-conserving surgery that precludes sparing of internal mammary lymph node chain from radiotherapy volume Decision at radiation oncologist's discretion Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: 75 and under Sex: Female Menopausal status: Not specified Performance status: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Cardiovascular: No prior cardiac disease Other: No prior malignancy except adequately treated nonmelanomatous skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: See Disease Characteristics Other: Concurrent enrollment in other randomized trials allowed
Sites / Locations
- Ziekenhuis Network Antwerpen Middelheim
- Cliniques Universitaires Saint-Luc
- Hopital de Jolimont
- Cazk Groeninghe - Campus Maria's Voorzienigheid
- U.Z. Gasthuisberg
- Algemeen Ziekenhuis Sint-Augustinus
- Institute of Oncology - Clinical Center University of Sarajevo
- Instituto de Radiomedicina
- Clinica Alemana
- CHR de Besancon - Hopital Jean Minjoz
- Institut Bergonie
- Centre de Lutte Contre le Cancer Georges-Francois Leclerc
- CHU de Grenoble - Hopital de la Tronche
- Service Cancerologie Polyclinique Clairval
- Centre Antoine Lacassagne
- Centre Eugene Marquis
- Centre Hospitalier Universitaire Henri Mondor
- Centre Leon Berard
- Centre Paul Strauss
- Institut Gustave Roussy
- Charite - Campus Charite Mitte
- Robert Roessle Comprehensive Cancer Center at University of Berlin - Charite Campus Buch
- Klinik I fuer Innere Medizin
- University of Erlangen-Nuremberg
- Universitaetsklinikum Essen
- Universitaetsklinikum Goettingen
- Universitaetsklinikum Tuebingen
- Rambam Medical Center
- Chaim Sheba Medical Center
- Ospedale Sant Anna
- Istituto Nazionale per la Ricerca sul Cancro
- Medisch Centrum Haaglanden
- Academisch Medisch Centrum
- Streekziekenhuis Gooi-Noord
- Radiotherapeutisch Instituut-(Riso)
- Medisch Spectrum Twente
- Academisch Ziekenhuis Groningen
- Radiotherapeutisch Instituut Limburg-Maastricht
- Dr. Bernard Verbeeten Instituut
- Academisch Ziekenhuis Utrecht
- Medical University of Gdansk
- Instituto Portugues de Oncologia Centro do Porto, SA
- Institut Catala D'Oncologia
- Hopital Cantonal Universitaire de Geneve
- Centre Hospitalier Universitaire Vaudois
- UniversitaetsSpital
- Istanbul University-Institute of Oncology
- Nottingham City Hospital NHS Trust