S9427, Suramin in Treating Patients With Stage III or Stage IV Adrenocortical Cancer Incurable by Surgery
Adrenocortical Carcinoma
About this trial
This is an interventional treatment trial for Adrenocortical Carcinoma focused on measuring stage III adrenocortical carcinoma, stage IV adrenocortical carcinoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed adrenocortical carcinoma in Stage III or IV and incurable by surgery Bidimensionally measurable disease PATIENT CHARACTERISTICS: Age: 18 and over Performance status: SWOG 0-2 Hematopoietic: WBC at least 4,000/mm3 Absolute granulocyte count at least 2,000/mm3 Platelet count at least 150,000/mm3 Prothrombin time and partial thromboplastin time no greater than upper limit of normal (ULN) Hepatic: SGOT and alkaline phosphatase no greater than 2 times ULN Renal: Creatinine clearance at least 50 mL/min Serum creatinine no greater than ULN Other: No second malignancy within 5 years except adequately treated basal cell or squamous cell carcinoma of the skin,in situ carcinoma of the cervix, or other cancer for which patient has been disease free for 5 years Not pregnant or nursing Effective contraception required of fertile patients PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent biologic therapy At least 4 weeks since prior biologic therapy (one regimen only) Chemotherapy: No concurrent chemotherapy At least 4 weeks since prior mitotane No other prior chemotherapy allowed Endocrine therapy: At least 6 weeks since prior hormonal therapy No concurrent hormonal therapy Radiotherapy: At least 4 weeks since prior radiation therapy (to less than 25% of bone marrow) No concurrent radiation therapy Surgery: Prior surgery allowed in relapsed patients with no other prior treatment
Sites / Locations
- MBCCOP - University of South Alabama
- CCOP - Greater Phoenix
- Arizona Cancer Center
- University of Arkansas for Medical Sciences
- Beckman Research Institute, City of Hope
- USC/Norris Comprehensive Cancer Center
- Jonsson Comprehensive Cancer Center, UCLA
- CCOP - Bay Area Tumor Institute
- Chao Family Comprehensive Cancer Center
- University of California Davis Medical Center
- UCSF Cancer Center and Cancer Research Institute
- CCOP - Santa Rosa Memorial Hospital
- University of Colorado Cancer Center
- CCOP - Christiana Care Health Services
- CCOP - Mount Sinai Medical Center
- CCOP - Atlanta Regional
- Dwight David Eisenhower Army Medical Center
- Cancer Research Center of Hawaii
- Loyola University Medical Center
- CCOP - Central Illinois
- University of Kansas Medical Center
- CCOP - Wichita
- Albert B. Chandler Medical Center, University of Kentucky
- MBCCOP - LSU Medical Center
- Tulane University School of Medicine
- Louisiana State University Hospital - Shreveport
- Boston Medical Center
- University of Michigan Comprehensive Cancer Center
- Barbara Ann Karmanos Cancer Institute
- Henry Ford Hospital
- CCOP - Grand Rapids Clinical Oncology Program
- Providence Hospital - Southfield
- University of Mississippi Medical Center
- Veterans Affairs Medical Center - Kansas City
- CCOP - Kansas City
- St. Louis University Health Sciences Center
- CCOP - St. Louis-Cape Girardeau
- CCOP - Montana Cancer Consortium
- University of New Mexico Cancer Research & Treatment Center
- CCOP - North Shore University Hospital
- Herbert Irving Comprehensive Cancer Center
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
- CCOP - Southeast Cancer Control Consortium
- Barrett Cancer Center, The University Hospital
- Cleveland Clinic Cancer Center
- CCOP - Columbus
- CCOP - Dayton
- Oklahoma Medical Research Foundation
- Oregon Cancer Center at Oregon Health Sciences University
- CCOP - Columbia River Program
- CCOP - Greenville
- CCOP - Upstate Carolina
- Simmons Cancer Center - Dallas
- Brooke Army Medical Center
- University of Texas Medical Branch
- Baylor College of Medicine
- Texas Tech University Health Science Center
- University of Texas Health Science Center at San Antonio
- CCOP - Scott and White Hospital
- Huntsman Cancer Institute
- Eastern Virginia Medical School
- MBCCOP - Massey Cancer Center
- CCOP - Virginia Mason Research Center
- Swedish Cancer Institute
- CCOP - Northwest
Arms of the Study
Arm 1
Experimental
Suramin