Antibiotic Therapy in Treating Patients With Low Grade Gastric Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring contiguous stage II marginal zone lymphoma, contiguous stage II small lymphocytic lymphoma, stage I marginal zone lymphoma, stage I small lymphocytic lymphoma, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven, previously untreated, low grade gastric lymphoma Clinical stage I and II1 No bulky disease No high grade component (grade 5 and 4, if monoclonality proven, allowed) Documented presence/absence of H. pylori infection Measurable and/or evaluable disease PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-2 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Other: Not pregnant or lactating Fertile patients must use effective contraception No prior or concurrent malignancies unless: At least 1 year remission Low risk or recurrence No prior gastric malignancy No nonmalignant disease causing poor medical risk No allergy to omeprazole PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to the abdomen Surgery: No prior gastric surgery except simple closure of perforated ulcer with or without wedge excision of the ulcer Other: No prior therapy for gastric lymphoma At least 30 days since experimental therapy No other concurrent experimental therapy At least 30 days since antibiotics with activity against H. pylori
Sites / Locations
- Royal United Hospital
- University Birmingham N.H.S. Trust
- Royal Free Hospital
- St. James's Hospital
- Saint Bartholomew's Hospital
- Royal Free Hospital School of Medicine
- Guy's, King's and St. Thomas' Hospitals Trust
- Royal Marsden NHS Trust
- Hammersmith Hospital
- Middlesex Hospital- Meyerstein Institute
- Charing Cross Hospital
- Clatterbridge Centre for Oncology NHS Trust
- Newcastle General Hospital
- Mount Vernon Hospital
- Nottingham City Hospital NHS Trust
- Oxford Radcliffe Hospital
- Royal South Hants Hospital
- Royal Marsden Hospital
- Aberdeen Royal Infirmary
- Western General Hospital
- Beatson Oncology Centre
- Royal Infirmary