Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder Cancer
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer
About this trial
This is an interventional treatment trial for Bladder Cancer focused on measuring recurrent bladder cancer, transitional cell carcinoma of the bladder, recurrent urethral cancer, recurrent transitional cell cancer of the renal pelvis and ureter
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven recurrent locally advanced or metastatic transitional cell urinary tract carcinoma that has been previously untreated with systemic chemotherapy Pelvic relapse after radiotherapy or surgery No relapse solely within a previously irradiated field Nodal or metastatic disease Lesions within the abdomen or pelvis must be assessed using CT scanning At least one site of disease must be previously unirradiated and assessable for response Bone metastases cannot be used as an indicator lesion Measurable disease PATIENT CHARACTERISTICS: Age: Not specified Performance Status: Not specified Life Expectancy: Not specified Hematopoietic: WBC at least 3,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Not specified Renal: Glomerular filtration rate at least 50 mL/min Creatinine clearance at least 25 mL/min PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior systemic chemotherapy Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics Surgery: See Disease Characteristics
Sites / Locations
- Porto Alegre Hospital
- Cancer Care Ontario-London Regional Cancer Centre
- Mount Sinai Hospital - Toronto
- Princess Margaret Hospital
- Hopital Sainte Justine
- Maria Hospital
- Antoni van Leeuwenhoekhuis
- Christchurch Hospital
- Norwegian Radium Hospital
- Groote Schuur Hospital, Cape Town
- Royal United Hospital
- University Birmingham
- Children's Hospital - Birmingham UK
- Bradford Hospitals NHS Trust
- Royal Sussex County Hospital
- Bristol Royal Hospital for Sick Children
- Bristol Oncology Centre
- Addenbrooke's NHS Trust
- Kent and Canterbury Hospital
- Walsgrave Hospital
- Derbyshire Royal Infirmary
- Derbyshire Children's Hospital
- Royal Devon and Exeter Hospital
- Gloucester Royal NHS Trust - Glouchester Royal Hospital
- Royal Surrey County Hospital
- Royal Free Hospital
- Huddersfield Royal Infirmary
- Cookridge Hospital
- St. James's Hospital
- University Hospitals of Leicester
- St. Bartholomew's Hospital
- Guy's, King's and St. Thomas' Hospitals Trust
- Westminster Hospital
- Middlesex Hospital- Meyerstein Institute
- University College Hospital
- Manchester Children's Hospitals (NHS Trust)
- Clatterbridge Centre for Oncology NHS Trust
- South Tees Acute Hospitals NHS Trust
- Newcastle General Hospital
- Royal Victoria Infirmary
- Mount Vernon Hospital
- Norfolk & Norwich Hospital
- Oxford Radcliffe Hospital
- Portsmouth Hospitals NHS Trust
- Children's Hospital - Sheffield
- Weston Park Hospital
- Royal South Hants Hospital
- Southampton General Hospital
- Royal Marsden Hospital
- Princess Royal Hospital
- Walsall Manor Hospital
- Southend General Hospital
- Royal Belfast Hospital for Sick Children
- Aberdeen Royal Infirmary
- Ninewells Hospital and Medical School
- Western General Hospital
- Royal Hospital for Sick Children
- Beatson Oncology Centre
- Royal Infirmary
- Ysbyty Gwynedd
- Llandough Hospital
- Royal Preston Hospital