S9624 Ifosfamide in Treating Patients With Meningeal Tumors
Chondrosarcoma, Adult Fibrosarcoma, Adult Leiomyosarcoma
About this trial
This is an interventional treatment trial for Chondrosarcoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven recurrent or unresectable: Malignant meningioma Intracranial hemangiopericytoma Primary central nervous system sarcoma, including: Fibrosarcoma Rhabdomyosarcoma Chondrosarcoma Leiomyosarcoma Measurable or evaluable disease on CT or MRI scan Persistent disease following biopsy or incomplete resection OR Recurrent disease following complete resection No benign meningioma No prior or current systemic sarcoma PATIENT CHARACTERISTICS: Age: 18 and over Performance status: SWOG 0-2 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm^3 Absolute granulocyte count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic: Not specified Renal: Creatinine no greater than 2.0 mg/dL Cardiovascular: No myocardial infarction within the past 3 months No active angina No unstable heart rhythms No congestive heart failure Other: HIV negative No allergy to study drugs No serious concurrent medical or psychiatric illness No uncontrolled peptic ulcer disease No prior malignancy within past 5 years except adequately treated: Basal or squamous cell carcinoma of the skin Carcinoma in situ of the cervix Not pregnant or nursing Effective contraception required of fertile patients PRIOR CONCURRENT THERAPY: Recovered from toxic effects of prior therapy and/or from postoperative complications Biologic therapy: Not specified Chemotherapy: No prior ifosfamide No other concurrent chemotherapy Endocrine therapy: No concurrent hormonal therapy (except estrogen replacement therapy) Corticosteroids allowed if dose is stable or decreasing Radiotherapy: At least 4 weeks since prior radiotherapy Progressive disease following radiation required No concurrent radiotherapy Surgery: See Disease Characteristics
Sites / Locations
- CCOP - Scottsdale Oncology Program
- City of Hope Comprehensive Cancer Center
- Veterans Affairs Medical Center - Palo Alto
- Stanford University Medical Center
- CCOP - Colorado Cancer Research Program, Incorporated
- CCOP - Christiana Care Health Services
- Veterans Affairs Medical Center - Gainesville
- H. Lee Moffitt Cancer Center and Research Institute
- Veterans Affairs Medical Center - Tampa (Haley)
- Emory University Hospital - Atlanta
- Veterans Affairs Medical Center - Atlanta (Decatur)
- CCOP - Central Illinois
- CCOP - Evanston
- CCOP - Illinois Oncology Research Association
- CCOP - Carle Cancer Center
- Indiana University Cancer Center
- Veterans Affairs Medical Center - Indianapolis (Roudebush)
- CCOP - Cedar Rapids Oncology Project
- CCOP - Iowa Oncology Research Association
- Iowa Methodist Medical Center
- Mercy Medical Center
- Iowa Lutheran Hospital
- MBCCOP - LSU Health Sciences Center
- CCOP - Ochsner
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Tuft-New England Medical Center
- Beth Israel Deaconess Medical Center
- CCOP - Michigan Cancer Research Consortium
- CCOP - Kalamazoo
- Veterans Affairs Medical Center - Minneapolis
- University of Minnesota Cancer Center
- Mayo Clinic Cancer Center
- CCOP - Missouri Valley Cancer Consortium
- Alegent Health-Midlands Community Hospital
- CCOP - Southern Nevada Cancer Research Foundation
- Veterans Affairs Medical Center - East Orange
- CCOP - Northern New Jersey
- Cancer Institute of New Jersey
- MBCCOP - University of New Mexico HSC
- Albert Einstein Clinical Cancer Center
- Veterans Affairs Medical Center - Brooklyn
- Veterans Affairs Medical Center - New York
- NYU School of Medicine's Kaplan Comprehensive Cancer Center
- James P. Wilmot Cancer Center
- Veterans Affairs Medical Center - Fargo
- CCOP - Merit Care Hospital
- Ireland Cancer Center
- Cleveland Clinic Taussig Cancer Center
- CCOP - Columbus
- CCOP - Oklahoma
- CCOP - Geisinger Clinic and Medical Center
- Milton S. Hershey Medical Center
- Drexel University Hospital
- Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
- Fox Chase Cancer Center
- University of Pittsburgh Cancer Institute
- Veterans Affairs Medical Center - Pittsburgh
- CCOP - MainLine Health
- CCOP - Sioux Community Cancer Consortium
- CCOP - St. Vincent Hospital Cancer Center, Green Bay
- Veterans Affairs Medical Center - Madison
- University of Wisconsin Comprehensive Cancer Center
- CCOP - Marshfield Medical Research and Education Foundation
- Medical College of Wisconsin Cancer Center
- Veterans Affairs Medical Center - Milwaukee (Zablocki)
- Westmead Hospital
- Instituto de Enfermedades Neoplasicas
- MBCCOP - San Juan
- Veterans Affairs Medical Center - San Juan
- San Juan City Hospital
Arms of the Study
Arm 1
Experimental
ifosfamide
ifosfamide