Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma
Lymphoma

About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage I adult Hodgkin lymphoma, stage II adult Hodgkin lymphoma, stage III adult Hodgkin lymphoma, stage IV adult Hodgkin lymphoma, adult lymphocyte depletion Hodgkin lymphoma, adult nodular sclerosis Hodgkin lymphoma, adult mixed cellularity Hodgkin lymphoma
Eligibility Criteria
Inclusion criteria: Histologically proven previously untreated classical Hodgkin's lymphoma The following stages are eligible: Locally extensive: Stage I-IIA/B with massive mediastinal adenopathy Advanced: Stage III or IV Measurable or evaluable disease Age of 16 and over ECOG Performance status 0-2 Disease-free of prior invasive malignancies for >5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix White blood cell (WBC) at least 4,000/mm³, (unless documented bone marrow involvement) Platelet count at least 100,000/mm³ (unless documented bone marrow involvement) Bilirubin no greater than 5.0 mg/dL Creatinine no greater than 2.0 mg/dL Ejection fraction determination recommended if over age 50 and/or have a history of cardiac disease Fertile patients must use effective contraception Prior corticosteroids allowed Prior surgery allowed Exclusion criteria: Pregnant or nursing Prior radiotherapy Prior chemotherapy Human immunodeficiency virus (HIV) positive
Sites / Locations
- Mobile Infirmary Medical Center
- CCOP - Western Regional, Arizona
- St. Joseph's Hospital and Medical Center
- Arizona Cancer Center at University of Arizona Health Sciences Center
- Alta Bates Comprehensive Cancer Center
- Peninsula Medical Center
- Eden Medical Center
- Mount Diablo Regional Cancer Center
- North Bay Cancer Center
- Kaiser Permanente - Fremont
- Marin Cancer Institute at Marin General Hospital
- Sutter Health - Western Division Cancer Research Group
- Kaiser Permanente Medical Center - Hayward
- Saint Rose Hospital
- Moores UCSD Cancer Center
- Memorial Medical Center Cancer Services
- Highland General Hospital at St. George's University School of Medicine
- Alta Bates Summit Medical Center - Summit Campus
- CCOP - Bay Area Tumor Institute
- Kaiser Permanente Medical Center - Oakland
- Valley Care Medical Center
- Kaiser Permanente Medical Center - Redwood City
- Kaiser Permanente Medical Center - Richmond
- Kaiser Permanente Medical Center - Roseville
- Sutter Cancer Center at Roseville Medical Center
- Sutter Cancer Center
- University of California Davis Cancer Center
- South Sacramento Kaiser-Permanente Medical Center
- Kaiser Permanente Medical Center - Sacramento
- Salinas Valley Memorial Hospital
- Kaiser Permanente Medical Office -Vandever Medical Office
- Veterans Affairs Medical Center - San Diego
- Kaiser Permanente Medical Center - San Francisco Geary Campus
- California Pacific Medical Center - California Campus
- Kaiser Permanente Medical Center - Santa Teresa
- J.C. Robinson, M.D. Regional Cancer Center
- Kaiser Foundation Hospital - San Rafael
- Kaiser Permanente Medical Center - Santa Clara Kiely Campus
- Kaiser Permanente Medical Center - Santa Rosa
- Kaiser Permanente Medical Center - South San Francisco
- Kaiser Permanente Medical Facility - Stockton
- Kaiser Permanente Medical Center - Vallejo
- Sutter Solano Medical Center
- Kaiser Permanente Medical Center - Walnut Creek
- John Muir/Mt. Diablo Comprehensive Cancer Center
- Aurora Presbyterian Hospital
- Boulder Community Hospital
- Memorial Hospital
- Penrose Cancer Center at Penrose Hospital
- Porter Adventist Hospital
- Presbyterian - St. Luke's Medical Center
- St. Joseph Hospital
- Rose Medical Center
- CCOP - Colorado Cancer Research Program, Incorporated
- Swedish Medical Center
- Front Range Cancer Specialists
- Poudre Valley Hospital
- Sky Ridge Medical Center
- Hope Cancer Care Center at Longmont United Hospital
- St. Mary-Corwin Regional Medical Center
- North Suburban Medical Center
- Beebe Medical Center
- CCOP - Christiana Care Health Services
- St. Francis Hospital
- Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
- Walter Reed Army Medical Center
- Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
- Broward General Medical Center Cancer Center
- Memorial Cancer Institute at Memorial Regional Hospital
- Mayo Clinic - Jacksonville
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center
- CCOP - Mount Sinai Medical Center
- University of Miami Sylvester Comprehensive Cancer Center
- M.D. Anderson Cancer Center - Orlando
- Piedmont Hospital
- Winship Cancer Institute of Emory University
- Northside Hospital Cancer Center
- Saint Joseph's Hospital of Atlanta
- CCOP - Atlanta Regional
- WellStar Cobb Hospital
- Charles B. Eberhart Cancer Center at DeKalb Medical Center
- Veterans Affairs Medical Center - Atlanta (Decatur)
- Gwinnett Medical Center
- Kennestone Cancer Center at Wellstar Kennestone Hospital
- Southern Regional Medical Center
- Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
- Tripler Army Medical Center
- Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
- St. Luke's Mountain States Tumor Institute - Boise
- Saint Anthony's Hospital at Saint Anthony's Health Center
- Rush-Copley Cancer Care Center
- St. Joseph Medical Center
- Graham Hospital
- Memorial Hospital
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- Hematology and Oncology Associates
- Veterans Affairs Medical Center - Lakeside Chicago
- Rush University Medical Center
- Mercy Hospital and Medical Center
- Swedish Covenant Hospital
- University of Chicago Cancer Research Center
- Decatur Memorial Hospital Cancer Care Institute
- Eureka Community Hospital
- Evanston Northwestern Health Care - Evanston Hospital
- Galesburg Clinic
- Galesburg Cottage Hospital
- InterCommunity Cancer Center of Western Illinois
- Ingalls Cancer Care Center at Ingalls Memorial Hospital
- Mason District Hospital
- Hinsdale Hematology Oncology Associates
- Hopedale Medical Complex
- Midwest Center for Hematology/Oncology
- Joliet Oncology-Hematology Associates, Limited - West
- Kewanee Hospital
- North Shore Oncology and Hematology Associates, Limited - Libertyville
- McDonough District Hospital
- Cardinal Bernardin Cancer Center at Loyola University Medical Center
- Trinity Medical Center - East
- Good Samaritan Regional Health Center
- Edward Hospital Cancer Center
- Hematology Oncology Consultants - Naperville
- Northwest Medical Specialist, PC
- BroMenn Regional Medical Center
- Community Cancer Center
- Community Hospital of Ottawa
- Oncology Hematology Associates of Central Illinois, PC - Ottawa
- Cancer Treatment Center at Pekin Hospital
- Proctor Hospital
- CCOP - Illinois Oncology Research Association
- Oncology Hematology Associates of Central Illinois, PC - Peoria
- Methodist Medical Center of Illinois
- OSF St. Francis Medical Center
- Illinois Valley Community Hospital
- Perry Memorial Hospital
- Swedish-American Regional Cancer Center
- Hematology Oncology Associates - Skokie
- Hematology/Oncology of the North Shore at Gross Point Medical Center
- Midwest Cancer Research Group, Incorporated
- St. Margaret's Hospital
- Valley Cancer Center
- Carle Cancer Center at Carle Foundation Hospital
- CCOP - Carle Cancer Center
- St. Francis Hospital and Health Centers - Beech Grove Campus
- Elkhart General Hospital
- Fort Wayne Medical Oncology and Hematology
- Howard Community Hospital at Howard Regional Health System
- Center for Cancer Therapy at LaPorte Hospital and Health Services
- Saint Anthony Memorial Health Centers
- Medical Consultants, P. C. at Ball Cancer Center
- Reid Hospital & Health Care Services, Incorporated
- CCOP - Northern Indiana CR Consortium
- Memorial Hospital of South Bend
- Saint Joseph Regional Medical Center
- McFarland Clinic, P. C.
- St. Luke's Hospital
- Cedar Rapids Oncology Associates
- Mercy Regional Cancer Center at Mercy Medical Center
- Genesis Regional Cancer Center at Genesis Medical Center
- Genesis Medical Center - West Campus
- Mercy Capitol Hospital
- CCOP - Iowa Oncology Research Association
- John Stoddard Cancer Center at Iowa Methodist Medical Center
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center
- Medical Oncology and Hematology Associates at Mercy Cancer Center
- Mercy Cancer Center at Mercy Medical Center - Des Moines
- John Stoddard Cancer Center at Iowa Lutheran Hospital
- Holden Comprehensive Cancer Center at University of Iowa
- Burgess Health Center
- Siouxland Hematology-Oncology Associates
- Siouxland Regional Cancer Center
- Mercy Medical Center - Sioux City
- St. Luke's Regional Medical Center
- Medical Oncology and Hematology Associates - West Des Moines
- Cancer Center of Kansas, P.A. - Chanute
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, P.A. - El Dorado
- Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
- Cancer Center of Kansas, P.A. - Kingman
- Southwest Medical Center
- Cancer Center of Kansas, P.A. - Newton
- Cancer Center of Kansas, P.A. - Parsons
- Cancer Center of Kansas, P.A. - Pratt
- Cancer Center of Kansas, P.A. - Salina
- Salina Regional Health Center
- Stormont-Vail Cancer Center
- St. Francis Comprehensive Cancer Center
- Cancer Center of Kansas, P.A. - Wellington
- Associates in Womens Health, P.A. - North Review
- Cancer Center of Kansas, P.A. - Medical Arts Tower
- Cancer Center of Kansas, P.A. - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Wesley Medical Center
- Cancer Center of Kansas, P.A. - Winfield
- James Graham Brown Cancer Center at University of Louisville
- Pennington Cancer Center at Baton Rouge General
- Mary Bird Perkins Cancer Center - Baton Rouge
- Ochsner Clinic of Baton Rouge
- Terrebonne General Medical Center
- Louisiana State University Health Sciences Center - Monroe
- MBCCOP - LSU Health Sciences Center
- Medical Center of Louisiana - New Orleans
- CCOP - Ochsner
- Ochsner Cancer Institute at Ochsner Clinic Foundation
- Veterans Affairs Medical Center - Shreveport
- Feist-Weiller Cancer Center at Louisiana State University Health Sciences
- CancerCare of Maine at Eastern Maine Medial Center
- Greenebaum Cancer Center at University of Maryland Medical Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Union Hospital Cancer Center at Union Hospital
- Sturdy Memorial Hospital
- Tufts - New England Medical Center
- Cancer Research Center at Boston Medical Center
- Franklin Medical Center
- Baystate Regional Cancer Program at D'Amour Center for Cancer Care
- Hickman Cancer Center at Bixby Medical Center
- St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
- CCOP - Michigan Cancer Research Consortium
- University of Michigan Comprehensive Cancer Center
- Battle Creek Health System Cancer Care Center
- Bay Regional Medical Center
- Mecosta County Medical Center
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
- Josephine Ford Cancer Center at Henry Ford Hospital
- Green Bay Oncology, Limited - Escanaba
- Genesys Hurley Cancer Institute
- Hurley Medical Center
- CCOP - Grand Rapids
- Lacks Cancer Center at Saint Mary's Mercy Medical Center
- Spectrum Health Cancer Care - Butterworth Campus
- Metropolitan Hospital
- Van Elslander Cancer Center at St. John Hospital and Medical Center
- Holland Community Hospital
- Green Bay Oncology, Limited - Iron Mountain
- Foote Hospital
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Haematology-Oncology Associates of Ohio and Michigan, P.C.
- Sparrow Regional Cancer Center
- Breslin Cancer Center at Ingham Regional Medical Center
- Upper Michigan Cancer Center at Marquette General Hospital
- Community Cancer Center of Monroe
- Mercy Memorial Hospital System
- Hackley Hospital
- Northern Michigan Hospital
- William Beaumont Hospital - Royal Oak Campus
- Seton Cancer Institute - Saginaw
- Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
- Providence Cancer Institute at Providence Hospital - Southfield Campus
- Munson Medical Center
- St. John Macomb Hospital
- MeritCare Clinic - Bemidji
- Brainerd Medical Center
- St. Joseph's Medical Center
- Fairview Ridges Hospital
- Mercy and Unity Cancer Center at Mercy Hospital
- Fairview Southdale Hospital
- Mercy and Unity Cancer Center at Unity Hospital
- Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
- Chippewa County - Montevideo Hospital
- Hubert H. Humphrey Cancer Center at North Memorial Medical Center
- Mayo Clinic Cancer Center
- CentraCare Clinic - River Campus
- Coborn Cancer Center
- CCOP - Metro-Minnesota
- Park Nicollet Health Services
- United Hospital
- Ridgeview Medical Center
- Hattiesburg Clinic, P.A.
- University of Mississippi Medical Center
- Saint Francis Medical Center
- Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- Siteman Cancer Center at Barnes-Jewish Hospital
- CCOP - St. Louis-Cape Girardeau
- David C. Pratt Cancer Center at St. John's Mercy
- CCOP - Cancer Research for the Ozarks
- St. John's Regional Health Center
- Hulston Cancer Center at Cox Medical Center South
- CCOP - Montana Cancer Consortium
- Hematology-Oncology Centers of the Northern Rockies - Billings
- Northern Rockies Radiation Oncology Center
- St. Vincent Healthcare
- Deaconess Billings Clinic Cancer Center
- Deaconess Billings Clinic - Downtown
- Bozeman Deaconess Hospital
- Internal Medicine Associates of Bozeman
- St. James Community Hospital
- Big Sky Oncology
- Great Falls Clinic
- Sletten Regional Cancer Institute
- St. Peter's Hospital
- Glacier Oncology, PLLC
- Kalispell Medical Oncology
- Kalispell Regional Medical Center
- Community Medical Center
- Montana Cancer Specialists at Montana Cancer Center
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
- Bryan LGH Medical Center West
- St. Elizabeth Regional Medical Center
- Great Plains Regional Medical Center
- Immanuel Medical Center
- Bergan Mercy Medical Center
- Creighton University Medical Center
- UNMC Eppley Cancer Center at the University of Nebraska Medical Center
- University Medical Center of Southern Nevada
- CCOP - Nevada Cancer Research Foundation
- New Hampshire Oncology-Hematology, PA - Hooksett
- Kingsbury Center for Cancer Care at Cheshire Medical Center
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- Elliot Regional Cancer Center
- Frisbie Memorial Hospital
- Cancer Institute of New Jersey at Hamilton
- St. Barnabas Medical Center
- Fox Chase Virtua Health Cancer Program - Marlton
- Mountainside Hospital Cancer Center
- Carol G. Simon Cancer Center at Morristown Memorial Hospital
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
- Booker Cancer Center at Riverview Medical Center
- Fox Chase Cancer Center at St. Francis Medical Center
- Cancer Institute of New Jersey at Cooper - Voorhees
- Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- University of New Mexico Cancer Research and Treatment Center
- Albert Einstein Cancer Center at Albert Einstein College of Medicine
- Our Lady of Mercy Medical Center Comprehensive Cancer Center
- Finger Lakes Hematology and Oncology
- Adirondack Cancer Care - Glens Falls
- Charles R. Wood Cancer Center at Glens Falls Hospital
- St. Vincent's Comprehensive Cancer Center - Manhattan
- Memorial Sloan-Kettering Cancer Center
- Oswego Hospital
- Highland Hospital of Rochester
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- CCOP - Hematology-Oncology Associates of Central New York
- SUNY Upstate Medical University Hospital
- Community General Hospital of Greater Syracuse
- Mission Hospitals - Memorial Campus
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
- Blumenthal Cancer Center at Carolinas Medical Center
- Wayne Memorial Hospital, Incorporated
- Wayne Radiation Oncology
- Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
- Lenoir Memorial Cancer Center
- Iredell Memorial Hospital
- Wilson Medical Center
- Forsyth Regional Cancer Center at Forsyth Medical Center
- Wake Forest University Comprehensive Cancer Center
- Bismarck Cancer Center
- Cancer Care Center at Medcenter One Hospital
- Mid Dakota Clinic, P. C.
- St. Alexius Medical Center
- CCOP - MeritCare Hospital
- MeritCare Medical Group
- McDowell Cancer Center at Akron General Medical Center
- Akron City Hospital
- Wood County Oncology Center
- Mercy Cancer Center at Mercy Medical Center
- Aultman Hospital Cancer Center at Aultman Health Foundation
- Adena Regional Medical Center
- Jewish Hospital Cancer Center
- Charles M. Barrett Cancer Center at University Hospital
- Case Comprehensive Cancer Center
- MetroHealth's Cancer Care Center at MetroHealth Medical Center
- Cleveland Clinic Taussig Cancer Center
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
- Riverside Methodist Hospital Cancer Care
- CCOP - Columbus
- Grant Riverside Cancer Services
- Mount Carmel West Hospital
- Doctors Hospital at Ohio Health
- Grandview Hospital
- Good Samaritan Hospital
- David L. Rike Cancer Center at Miami Valley Hospital
- Samaritan North Cancer Care Center
- Veterans Affairs Medical Center - Dayton
- CCOP - Dayton
- Grady Memorial Hospital
- Blanchard Valley Medical Associates
- Fremont Memorial Hospital
- Community Oncology Group at Cleveland Clinic Cancer Center
- Kenton Oncology, Incorporated
- Charles F. Kettering Memorial Hospital
- Fairfield Medical Center
- St. Rita's Medical Center
- Lima Memorial Hospital
- Strecker Cancer Center at Marietta Memorial Hospital
- Northwest Ohio Oncology Center
- St. Luke's Hospital
- Middletown Regional Hospital
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
- St. Charles Mercy Hospital
- Toledo Clinic - Oregon
- Firelands Regional Medical Center
- North Coast Cancer Care, Incorporated
- Mercy Medical Center
- Community Hospital of Springfield and Clark County
- Promedica Cancer Center at Flower Hospital
- Mercy Hospital of Tiffin
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical University of Ohio Cancer Center
- CCOP - Toledo Community Hospital
- Toledo Clinic, Incorporated - Main Clinic
- Toledo Surgical Specialists
- UVMC Cancer Care Center at Upper Valley Medical Center
- Fulton County Health Center
- Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
- Cleveland Clinic - Wooster
- Ruth G. McMillan Cancer Center at Greene Memorial Hospital
- Genesis - Good Samaritan Hospital
- Comanche County Memorial Hospital
- LaFortune Cancer Center at St. John Medical Center
- Natalie Warren Bryant Cancer Center at St. Francis Hospital
- Legacy Mount Hood Medical Center
- Providence Milwaukie Hospital
- Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center
- Providence Cancer Center at Providence Portland Medical Center
- CCOP - Columbia River Oncology Program
- Providence St. Vincent Medical Center
- Legacy Emanuel Hospital and Health Center & Children's Hospital
- Kaiser Permanente Health Care - Portland
- Legacy Meridian Park Hospital
- Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
- Bryn Mawr Hospital
- Delaware County Regional Cancer Center at Delaware County Memorial Hospital
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- St. Mary Regional Cancer Center
- Paoli Memorial Hospital
- Abramson Cancer Center of the University of Pennsylvania
- Joan Karnell Cancer Center at Pennsylvania Hospital
- Fox Chase Cancer Center
- Mercy Hospital Cancer Center - Scranton
- Hematology and Oncology Associates
- Chester County Hospital
- Jennersville Regional Hospital
- CCOP - MainLine Health
- Lankenau Cancer Center at Lankenau Hospital
- Hollings Cancer Center at Medical University of South Carolina
- Bon Secours St. Francis Health System
- CCOP - Greenville
- Oncology Services of Aberdeen
- Avera Cancer Institute
- Medical X-Ray Center, PC
- Sioux Valley Hospital and University of South Dakota Medical Center
- Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
- Baptist Regional Cancer Center at Baptist Hospital of East Tennessee
- Thompson Cancer Survival Center
- Vanderbilt-Ingram Cancer Center
- Brooke Army Medical Center
- Wilford Hall Medical Center
- Doctor's Hospital of Laredo
- UMC Southwest Cancer and Research Center
- Veterans Affairs Medical Center - San Antonio (Murphy)
- University of Texas Health Science Center at San Antonio
- Cancer Therapy and Research Center
- University Hospital - San Antonio
- CCOP - Scott and White Hospital
- American Fork Hospital
- Logan Regional Hospital
- Cottonwood Hospital Medical Center
- McKay-Dee Hospital Center
- Utah Valley Regional Medical Center - Provo
- Dixie Regional Medical Center - East Campus
- Utah Cancer Specialists at UCS Cancer Center
- Huntsman Cancer Institute at University of Utah
- LDS Hospital
- Green Mountain Oncology Group
- Southwestern Vermont Regional Cancer Center
- Mountainview Medical
- Fletcher Allen Health Care - University Health Center Campus
- Mount Ascutney Hospital
- Danville Regional Medical Center
- Virginia Oncology Associates - Hampton
- Southwest Virginia Regional Cancer Center
- Massey Cancer Center at Virginia Commonwealth University
- St. Joseph Hospital Community Cancer Center
- Olympic Hematology and Oncology
- Skagit Valley Hospital Cancer Care Center
- CCOP - Virginia Mason Research Center
- Fred Hutchinson Cancer Research Center
- Harborview Medical Center
- Minor and James Medical, PLLC
- Group Health Central Hospital
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- Polyclinic First Hill
- University Cancer Center at University of Washington Medical Center
- North Puget Oncology at United General Hospital
- Cancer Care Northwest - Spokane South
- Providence Cancer Center at Sacred Heart Medical Center
- Providence Cancer Center at Holy Family Hospital
- Madigan Army Medical Center - Tacoma
- Southwest Washington Medical Center Cancer Center
- Wenatchee Valley Clinic
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- Washington Hematology-Oncology Specialists
- West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
- Mary Babb Randolph Cancer Center at West Virginia University Hospitals
- Green Bay Oncology, Limited at St. Vincent Hospital
- Green Bay Oncology, Limited at St. Mary's Hospital
- St. Mary's Hospital Medical Center - Green Bay
- St. Vincent Hospital Regional Cancer Center
- Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
- Dean Medical Center - Fish Hatchery
- University of Wisconsin Comprehensive Cancer Center
- Holy Family Memorial Medical Center Cancer Care Center
- Bay Area Cancer Care Center at Bay Area Medical Center
- Marshfield Clinic - Marshfield Center
- Medical College of Wisconsin Cancer Center
- Green Bay Oncology, Limited - Oconto Falls
- Green Bay Oncology, Limited - Sturgeon Bay
- Welch Cancer Center at Sheridan Memorial Hospital
- Tom Baker Cancer Centre - Calgary
- Cross Cancer Institute at University of Alberta
- British Columbia Cancer Agency - Vancouver Cancer Centre
- CancerCare Manitoba
- Saint John Regional Hospital
- Nova Scotia Cancer Centre
- Margaret and Charles Juravinski Cancer Centre
- McMaster Children's Hospital at Hamilton Health Sciences
- London Regional Cancer Program at London Health Sciences Centre
- St. Catharines General Hospital at Niagara Health System
- Northeastern Ontario Regional Cancer Centre
- Northwestern Ontario Regional Cancer Care at Thunder Bay Regional Health Sciences Centre
- Toronto Sunnybrook Regional Cancer Centre at Sunnybrook Health Sciences Centre
- Princess Margaret Hospital
- Hopital Charles Lemoyne
- Maisonneuve-Rosemont Hospital
- Centre Hospitalier de l'Universite de Montreal
- McGill Cancer Centre at McGill University
- Centre Hospitalier Universitaire de Quebec
- Allan Blair Cancer Centre at Pasqua Hospital
- Saskatoon Cancer Centre at the University of Saskatchewan
- Pretoria Academic Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Arm A (ABVD)
Arm B (Stanford V)
Arm A (ABVD): Patients receive doxorubicin (25 mg/m²), bleomycin (10 u/m²), vinblastine (6 mg/m²), and dacarbazine (375 mg/m²) intravenously (IV) on days 1 and 15. Courses repeat every 28 days. Patients are restaged after 4 courses. Patients who are in complete remission receive 2 additional courses. Patients with a partial response or less are evaluated after 6 courses, and if there is an ongoing response, patients may receive 2 additional courses for a total of 8. If no ongoing response is observed, patients are removed from the study. All patients with massive mediastinal disease, regardless of stage, receive radiotherapy 2-3 weeks after completion of chemotherapy.
Arm B (Stanford V): Patients receive Stanford V chemotherapy comprising doxorubicin (25 mg/m²) and vinblastine (6 mg/m²) IV on day 1 of weeks 1, 3, 5, 7, 9, and 11; vincristine (1.4 mg/m²) and bleomycin (5 u/m²) IV on day 1 of weeks 2, 4, 6, 8, 10, and 12; mechlorethamine (6 mg/m²) IV on day 1 of weeks 1, 5, and 9 (if mechlorethamine is unavailable, may substitute with cyclophosphamide [375 mg/m²] IV); etoposide (60 mg/m²) IV on days 1 and 2 of weeks 3, 7, and 11; and oral prednisone (40 mg/m²) every other day of weeks 1-9 followed by a taper. All patients with bulky disease receive radiotherapy 2-3 weeks after completion of chemotherapy.