Aminocamptothecin in Treating Patients With Recurrent or Refractory Ovarian Epithelial Cancer or Primary Cancer of the Peritoneum
Ovarian Cancer, Primary Peritoneal Cavity Cancer
About this trial
This is an interventional treatment trial for Ovarian Cancer focused on measuring recurrent ovarian epithelial cancer, primary peritoneal cavity cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed recurrent or persistent ovarian epithelial cancer or primary peritoneal carcinoma Progressive disease on platinum-based treatment alone or in combination Two prior treatment regimens allowed only if other regimen was paclitaxel OR recurrence within 6 months of chemotherapy Measurable disease Not eligible for a higher priority GOG protocol PATIENT CHARACTERISTICS: Age: 13 and over Performance status: GOG 0-2 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm3 Platelet count at least 100,000/mm3 Granulocyte count at least 1,500/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL SGOT/SGPT no greater than 2.5 times upper limit of normal (ULN) Alkaline phosphatase no greater than 2.5 times ULN Renal: Creatinine no greater than 1.5 mg/dL Other: No significant infection Not pregnant Fertile patients must use effective contraception At least 5 years since prior malignancy; no prior chemotherapy or radiotherapy for that malignancy No concurrent malignancy other than non-melanoma skin cancer PRIOR CONCURRENT THERAPY: Biologic therapy: At least 4 weeks since prior biologic therapy Chemotherapy: See Disease Characteristics At least 4 weeks since prior chemotherapy and recovered No prior treatment with aminocamptothecin Endocrine therapy: At least 4 weeks since prior endocrine therapy Radiotherapy: At least 4 weeks since prior radiotherapy and recovered No prior radiotherapy to site(s) of measurable disease used on this trial No prior radiotherapy to more than 25% of marrow-bearing areas Surgery: At least 4 weeks since prior surgery
Sites / Locations
- University of Alabama Comprehensive Cancer Center
- CCOP - Greater Phoenix
- USC/Norris Comprehensive Cancer Center
- Jonsson Comprehensive Cancer Center, UCLA
- Chao Family Comprehensive Cancer Center
- Women's Cancer Center
- University of Colorado Cancer Center
- Vincent T. Lombardi Cancer Research Center, Georgetown University
- Walter Reed Army Medical Center
- H. Lee Moffitt Cancer Center and Research Institute
- Emory University Hospital - Atlanta
- CCOP - Atlanta Regional
- MBCCOP - Hawaii
- Rush-Presbyterian-St. Luke's Medical Center
- University of Chicago Cancer Research Center
- CCOP - Central Illinois
- CCOP - Evanston
- Indiana University Cancer Center
- University of Iowa Hospitals and Clinics
- Albert B. Chandler Medical Center, University of Kentucky
- Johns Hopkins Oncology Center
- Medicine Branch
- Radiation Oncology Branch
- University of Massachusetts Memorial Medical Center
- CCOP - Ann Arbor Regional
- Barbara Ann Karmanos Cancer Institute
- University of Minnesota Cancer Center
- University of Mississippi Medical Center
- Keesler Medical Center - Keesler AFB
- CCOP - Kansas City
- Washington University School of Medicine
- CCOP - Montana Cancer Consortium
- CCOP - Missouri Valley Cancer Consortium
- CCOP - Southern Nevada Cancer Research Foundation
- Cooper Hospital/University Medical Center
- Cancer Center of Albany Medical Center
- State University of New York Health Science Center at Brooklyn
- North Shore University Hospital
- Memorial Sloan-Kettering Cancer Center
- University of Rochester Cancer Center
- State University of New York Health Sciences Center - Stony Brook
- Lineberger Comprehensive Cancer Center, UNC
- Duke Comprehensive Cancer Center
- Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
- Barrett Cancer Center, The University Hospital
- Ireland Cancer Center
- Cleveland Clinic Cancer Center
- Arthur G. James Cancer Hospital - Ohio State University
- University of Oklahoma College of Medicine
- CCOP - Sooner State
- CCOP - Columbia River Program
- Abington Memorial Hospital
- Milton S. Hershey Medical Center
- University of Pennsylvania Cancer Center
- Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
- Fox Chase Cancer Center
- Medical University of South Carolina
- CCOP - Upstate Carolina
- CCOP - Baptist Cancer Institute
- Brookview Research, Inc.
- Simmons Cancer Center - Dallas
- University of Texas - MD Anderson Cancer Center
- University of Washington Medical Center
- Tacoma General Hospital
- Tom Baker Cancer Center - Calgary