Dimesna in Treating Patients With Solid Tumors Who Are Undergoing Treatment With Cisplatin and Paclitaxel
Head and Neck Cancer, Lung Cancer, Neurotoxicity
About this trial
This is an observational trial for Head and Neck Cancer focused on measuring stage III non-small cell lung cancer, recurrent non-small cell lung cancer, stage III ovarian epithelial cancer, stage IV ovarian epithelial cancer, recurrent ovarian epithelial cancer, stage IV non-small cell lung cancer, stage III squamous cell carcinoma of the lip and oral cavity, stage IV squamous cell carcinoma of the lip and oral cavity, recurrent squamous cell carcinoma of the lip and oral cavity, stage III squamous cell carcinoma of the oropharynx, stage IV squamous cell carcinoma of the oropharynx, recurrent squamous cell carcinoma of the oropharynx, stage III squamous cell carcinoma of the nasopharynx, stage IV squamous cell carcinoma of the nasopharynx, recurrent squamous cell carcinoma of the nasopharynx, stage III squamous cell carcinoma of the hypopharynx, stage IV squamous cell carcinoma of the hypopharynx, recurrent squamous cell carcinoma of the hypopharynx, stage III squamous cell carcinoma of the larynx, stage IV squamous cell carcinoma of the larynx, recurrent squamous cell carcinoma of the larynx, stage III squamous cell carcinoma of the paranasal sinus and nasal cavity, stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity, recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity, neurotoxicity, recurrent salivary gland cancer, stage IV salivary gland cancer, salivary gland squamous cell carcinoma, stage III salivary gland cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed non-small cell lung cancer, ovarian carcinoma, squamous cell carcinoma of the head and neck, tumor types for which no standard treatment exists, or tumor types that have failed standard therapy Paclitaxel and cisplatin combination therapy must be an appropriate option in treating disease No potentially curable type of cancer (e.g., newly diagnosed testicular cancer) PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: At least 6 weeks Hematopoietic: WBC greater than 4,000/mm^3 Absolute neutrophil count greater than 1,500/mm^3 Platelet count greater than 100,000/mm^3 Hepatic: Bilirubin normal SGOT and SGPT normal Renal: Creatinine normal Creatinine clearance at least 60 mL/min Cardiovascular: No evidence of congestive heart failure No uncontrolled moderate to severe hypertension Includes patients with persistent elevated systolic blood pressures of greater than 170 mm Hg and diastolic blood pressures of greater than 100 mm Hg for more than 1 month while under medical treatment Other: No active infection No perceived or actual clinical risk of cisplatin induced toxicity that exceeds the clinical benefit of using cisplatin therapy No known history of severe hypersensitivity to polyoxyl 35 castor oil vehicle No severe medical problems unrelated to malignancy that would interfere with compliance in this study Not pregnant Effective contraception required of all fertile patients PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent colony stimulating factors except for febrile neutropenia No concurrent aminoglycoside therapy except for febrile neutropenia or other life threatening infections No concurrent immunotherapy Chemotherapy: At least 6 weeks since prior nitrosoureas or mitomycin At least 3 weeks since other prior chemotherapy No other concurrent chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to measurable disease Surgery: At least 2 weeks since prior major surgery Other: No other concurrent investigational agents
Sites / Locations
- University of Chicago Cancer Research Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Roswell Park Cancer Institute