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Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome

Primary Purpose

Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

asparaginase

cytarabine

daunorubicin hydrochloride

methotrexate

therapeutic hydrocortisone

thioguanine

About this trial

This is an interventional treatment trial for Leukemia focused on measuring childhood myelodysplastic syndromes, untreated childhood acute myeloid leukemia and other myeloid malignancies, childhood acute myeloblastic leukemia without maturation (M1), childhood acute myeloblastic leukemia with maturation (M2), childhood acute myelomonocytic leukemia (M4), childhood acute erythroleukemia (M6), childhood acute megakaryocytic leukemia (M7), refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, de novo myelodysplastic syndromes, childhood acute minimally differentiated myeloid leukemia (M0), childhood acute monocytic leukemia (M5b), childhood acute monoblastic leukemia (M5a), myelodysplastic/myeloproliferative neoplasm, unclassifiable, juvenile myelomonocytic leukemia, chronic myelomonocytic leukemia, secondary myelodysplastic syndromes

Eligibility Criteria

undefined - 21 Years (Child, Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Cytogenetically proven Down Syndrome (constitutional trisomy 21) with transient myeloproliferative disorder (TMD), myelodysplastic syndromes (MDS), or acute myelogenous leukemia (AML) Must be confirmed by bone marrow aspirate, cerebrospinal fluid exam, or blood test Trisomy 21 mosaicism allowed Group I: Diagnosis of TMD in patients no older than 90 days at initial presentation Must have nonerythroid blasts (any amount) in the peripheral blood and one of the following: Verification with a second sample More than 5% bone marrow blasts Hepatomegaly and/or splenomegaly Lymphadenopathy Cardiac or pleural effusions OR Histologically or cytologically proven TMD with blasts in an affected organ or in fluid (pericardial, pleural, or peritoneal) Bone marrow aspirate is required Group II (closed to accrual as of 6/24/04): Diagnosis of MDS or AML (except M3 subtype) in patients older than 90 days with more than 29% blasts in bone marrow (with or without history of TMD), or any of the following histologies: Refractory anemia (RA) RA with excess blasts (RAEB) RAEB in transformation RA with ringed sideroblasts (RARS) Primary cytopenia (later confirmed by bone marrow aspirate as due to marrow hypoplasia) defined by one or more of the following: Absolute neutrophil count less than 500/mm^3 Untransfused platelet count less than 30,000/mm^3 Untransfused hemoglobin less than 8 g/dL The following diagnoses will be observed only: RA with mild cytopenias* RARS with mild cytopenias* Mild primary cytopenias (one or more) without dysplasia (confirmed by hypoplastic bone marrow exam) NOTE: * Platelet count 30-150,000/mm3, absolute neutrophil count 500-1,499/mm3, and hemoglobin greater than 8 g/dL Granulocytic sarcoma (chloroma), with or without bone marrow involvement, allowed PATIENT CHARACTERISTICS: Age: See Disease Characteristics 21 and under Performance status: Not specified Life expectancy: Not specified Hematopoietic: See Disease Characteristics Hepatic: See Disease Characteristics Renal: Not specified Cardiovascular: Shortening fraction greater than 27% by echocardiogram* OR Ejection fraction greater than 47% by radionuclide angiogram* NOTE: *For patients with MDS and AML (as of 2/24/04, previously diagnosed MDS or AML closed to accrual; MDS or AML that develops (secondary to TMD) after study enrollment or MDS that requires initial observation [with or without subsequent treatment] allowed) PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Prior chemotherapy for TMD allowed No prior chemotherapy for malignancy Endocrine therapy: Concurrent topical or inhaled steroids for other conditions allowed Radiotherapy: No prior radiotherapy for malignancy Surgery: Not specified Other: No prior antileukemic therapy Prior enrollment on this study for TMD allowed

Sites / Locations

University of Alabama at Birmingham Comprehensive Cancer Center
University of South Alabama Cancer Research Institute
Phoenix Children's Hospital
Arizona Cancer Center at University of Arizona Health Sciences Center
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Southern California Permanente Medical Group
City of Hope Comprehensive Cancer Center
Rebecca and John Moores UCSD Cancer Center
Loma Linda University Cancer Institute at Loma Linda University Medical Center
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital
Children's Hospital Los Angeles
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center
Jonsson Comprehensive Cancer Center, UCLA
Children's Hospital Central California
Children's Hospital and Research Center at Oakland
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
Children's Hospital of Orange County
Lucile Packard Children's Hospital at Stanford University Medical Center
Sutter Cancer Center
University of California Davis Cancer Center
Kaiser Permanente Medical Center - Sacramento
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
Children's Hospital and Health Center, San Diego
UCSF Comprehensive Cancer Center
Santa Barbara Cottage Hospital
Kaiser Permanente Medical Center - Santa Clara
David Grant Medical Center
Children's Hospital of Denver
Presbyterian - St. Luke's Medical Center
University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center
Yale Comprehensive Cancer Center
Alfred I. duPont Hospital for Children
Lombardi Cancer Center at Georgetown University Medical Center
Children's National Medical Center
Walter Reed Army Medical Center
Broward General Medical Center
Children's Hospital of Southwest Florida
Shands Cancer Center at the University of Florida Health Science Center
Joe DiMaggio Children's Hospital at Memorial
Nemours Children's Clinic
Jackson Memorial Hospital
Miami Children's Hospital
Baptist Hospital of Miami
Florida Hospital Cancer Institute
Nemours Children's Clinic-Orlando
Sacred Heart Children's Hospital
All Children's Hospital
St. Joseph's Children's Hospital
St. Mary's Hospital
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish RiteCampus
MBCCOP-Medical College of Georgia Cancer Center
Medical Center of Central Georgia
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Cancer Research Center of Hawaii
MBCCOP - Hawaii
Tripler Army Medical Center
Mountain States Tumor Institute - Boise
University of Chicago Cancer Research Center
Rush University Medical Center
University of Illinois Medical Center
Children's Memorial Hospital - Chicago
Advocate Hope Children's Hospital
Lutheran General Cancer Care Center
Saint Jude Midwest Affiliate
Southern Illinois University School of Medicine
Riley Children Cancer Center at Riley Hospital for Children
St. Vincent Hospital and Health Care Center
Blank Children's Hospital
John Stoddard Cancer Center at Iowa Methodist Medical Center
Holden Comprehensive Cancer Center at University of Iowa
Wesley Medical Center
Markey Cancer Center at University of Kentucky Chandler Medical Center
Kosair Children's Hospital
MBCCOP - LSU Health Sciences Center
Tulane Cancer Center at Tulane University Hospital and Clinic
Children's Hospital of New Orleans
Ochsner Clinic Foundation
Eastern Maine Medical Center
Maine Children's Cancer Program
Greenebaum Cancer Center at University of Maryland Medical Center
Sinai Hospital of Baltimore
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Floating Hospital for Children
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Baystate Regional Cancer Program at Baystate Medical Center
University of Massachusetts Memorial Medical Center - University Campus
University of Michigan Comprehensive Cancer Center
Children's Hospital of Michigan
Josephine Ford Cancer Center at Henry Ford Hospital
Van Elslander Cancer Center at St. John Hospital and Medical Center
Hurley Medical Center
Spectrum Health and DeVos Children's Hospital
Bronson Methodist Hospital
Breslin Cancer Center at Ingham Regional Medical Center
CCOP - Beaumont
William Beaumont Hospital - Royal Oak
St. Mary's - Duluth Clinic Cancer Center
Children's Hospitals and Clinics - Minneapolis
Mayo Clinic Cancer Center
Children's Hospitals and Clinics - Minnesota
University of Mississippi Medical Center
Children's Mercy Hospital
Cardinal Glennon Children's Hospital
St. Louis Children's Hospital
Children's Hospital of Omaha
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Sunrise Hospital and Medical Center
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Cancer Center at Hackensack University Medical Center
Cancer Institute of New Jersey at Robert Wood Johnson University Hospital
Newark Beth Israel Medical Center
St. Joseph's Hospital and Medical Center
Valerie Fund Children's Center at Atlantic Health
University of New Mexico Cancer Research and Treatment Center
Cancer Center of Albany Medical Center
Albert Einstein Clinical Cancer Center
Brooklyn Hospital Center
SUNY Downstate Medical Center
Brookdale University Hospital and Medical Center
Comprehensive Cancer Center at Maimonides Medical Center
Roswell Park Cancer Institute
North Shore University Hospital
Schneider Children's Hospital
Memorial Sloan-Kettering Cancer Center
New York Weill Cornell Cancer Center at Cornell University
Mount Sinai School of Medicine
Herbert Irving Comprehensive Cancer Center at Columbia University
James P. Wilmot Cancer Center at University of Rochester Medical Center
Long Island Cancer Center at Stony Brook University Hospital
University Hospital at State University of New York - Upstate Medical University
New York Medical College
Mission Hospitals
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Blumenthal Cancer Center at Carolinas Medical Center
Presbyterian Healthcare
Duke Comprehensive Cancer Center
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina
Comprehensive Cancer Center at Wake Forest University
Dakota Cancer Institute at Innovis Health - Dakota Clinic
Children's Hospital Medical Center of Akron
Cincinnati Children's Hospital Medical Center
Ireland Cancer Center
Cleveland Clinic Taussig Cancer Center
Children's Hospital of Columbus
Children's Medical Center - Dayton
Toledo Children's Hospital
St. Vincent Mercy Medical Center
Forum Health-Tod Childrens Hospital
Children's Hospital at Oklahoma University Medical Center
CCOP - Oklahoma
Natalie Warren Bryant Cancer Center
CCOP - Columbia River Oncology Program
Legacy Emanuel Hospital and Health Center & Children's Hospital
Doernbecher Children's Hospital at Oregon Health & Science University
Geisinger Medical Center
Penn State Cancer Institute at Milton S. Hershey Medical Center
Children's Hospital of Philadelphia
St. Christopher's Hospital for Children
Children's Hospital of Pittsburgh
Rhode Island Hospital
Hollings Cancer Center at Medical University of South Carolina
Palmetto Health South Carolina Cancer Center
Children's Hospital of Greenville Hospital System
Avera Cancer Institute
Sioux Valley Hospital at University of South Dakota Medical Center
East Tennessee State University Cancer Center at Johnson City Medical Center
East Tennessee Children's Hospital
St. Jude Children's Research Hospital
Vanderbilt Children's Hospital
Texas Tech University Health Sciences Center School of Medicine
Children's Hospital of Austin
Medical City Dallas Hospital
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
Cook Children's Medical Center - Fort Worth
University of Texas Medical Branch
University of Texas - MD Anderson Cancer Center
Baylor College of Medicine
San Antonio Military Pediatric Cancer and Blood Disorders Center
Covenant Children's Hospital
University of Texas Health Science Center at San Antonio
MBCCOP - South Texas Pediatrics
Methodist Cancer Center at Methodist Specialty and Transplant Hospital
CCOP - Scott and White Hospital
Center for Cancer Prevention and Care at Scott and White Clinic
Huntsman Cancer Institute
Vermont Cancer Center at University of Vermont
Cancer Center at the University of Virginia
Inova Fairfax Hospital
Children's Hospital of the King's Daughters
Naval Medical Center, Portsmouth
Massey Cancer Center at Virginia Commonwealth University
Carilion Medical Center for Children
Children's Hospital and Regional Medical Center - Seattle
Fred Hutchinson Cancer Research Center
Group Health Central Hospital
Deaconess Medical Center
Mary Bridge Children's Hospital and Health Center
Madigan Army Medical Center
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
Cabell Huntington Hospital
West Virginia University Hospitals
Bellin Memorial Hospital
CCOP - St. Vincent Hospital Cancer Center, Green Bay
St. Vincent Hospital
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
University of Wisconsin Comprehensive Cancer Center
Marshfield Clinic
CCOP - Marshfield Clinic Research Foundation
Midwest Children's Cancer Center
Sydney Children's Hospital
Children's Hospital at Westmead
Royal Children's Hospital
Women's and Children's Hospital
Royal Children's Hospital
Princess Margaret Hospital for Children
Alberta Children's Hospital
Cross Cancer Institute
British Columbia Children's Hospital
CancerCare Manitoba
Janeway Children's Health and Rehabilitation Centre
IWK Health Centre
McMaster Children's Hospital at Hamilton Health Sciences
Children's Hospital of Western Ontario
Children's Hospital of Eastern Ontario
Hospital for Sick Children
McGill University Health Center - Montreal Children's Hospital
Hopital Sainte Justine
Centre de Recherche du Centre Hospitalier de l'Universite Laval
Allan Blair Cancer Centre at Pasqua Hospital
Saskatoon Cancer Centre
Academisch Ziekenhuis Groningen
Starship Children's Hospital
Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus
San Jorge Childrens Hospital
Swiss Pediatric Oncology Group Bern
Swiss Pediatric Oncology Group Geneva
Swiss Pediatric Oncology Group Lausanne

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Arm Label

Arm A: TMD patients only

Arm B: AML/MDS patients only

Arm Description

Patients are observed if their transient myeloproliferative disorder (TMD) does not require intervention. Patients who require therapy for TMD undergo leukapheresis or exchange transfusion for up to 3 consecutive days. If the TMD does not resolve or there is significant organ involvement, patients receive low-dose cytarabine IV continuously on days 0-4. Treatment repeats at least every 2 weeks for up to 4 courses. Patients who experience a recurrence of TMD at least 8 weeks after resolution or have refractory disease may proceed to group II for further treatment. patients will continue to be followed for remission induction, EFS, DFS and OS regardless of the type of leukemia that develops.

(closed to accrual as of 6/24/04 except for patients first enrolled in group I): Patients receive induction therapy comprising cytarabine IV continuously, daunorubicin hydrochloride IV continuously, and oral thioguanine twice daily on days 0-3. Treatment repeats every 28 days for 4 courses. Patients with no CNS disease at diagnosis receive cytarabine intrathecally (IT) on day 0. Patients with CNS disease at diagnosis receive cytarabine IT on days 0, 5, and 7. If CNS disease persists on day 7, patients receive up to 6 courses of cytarabine IT, therapeutic hydrocortisone IT, and methotrexate IT, twice weekly beginning on day 10. Asparaginase during Intensification 1 day 1 hour 18.

Outcomes

Primary Outcome Measures

Event Free Survival

Secondary Outcome Measures

Full Information

NCT ID

NCT00003593

First Posted

November 1, 1999

Last Updated

June 26, 2013

Sponsor

Children's Oncology Group

Collaborators

National Cancer Institute (NCI)

1. Study Identification

Unique Protocol Identification Number

NCT00003593

Brief Title

Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome

Official Title

Treatment of Children With Down Syndrome (DS) and Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), and Transient Myeloproliferative Disorder (TMD): A Phase III Group-Wide Study

Study Type

Interventional

2. Study Status

Record Verification Date

June 2013

Overall Recruitment Status

Completed

Study Start Date

June 1999 (undefined)

Primary Completion Date

March 2007 (Actual)

Study Completion Date

April 2012 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Children's Oncology Group

Collaborators

National Cancer Institute (NCI)

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase III trial to study the effectiveness of combination chemotherapy in treating children who have Down syndrome and myeloproliferative disorder, acute myelogenous leukemia, or myelodysplastic syndrome.

Detailed Description

OBJECTIVES: Evaluate the efficacy of reduced-dose induction and intensification chemotherapy, in terms of remission rate, disease-free survival rate, and acute morbidity and mortality, in children with Down syndrome and acute myelogenous leukemia or myelodysplastic syndromes. Define the understanding of the natural history of transient myeloproliferative disorder (TMD) in children with Down syndrome. Determine whether there is a reduction of sequelae in long-term survivors after treatment with this regimen. Determine the incidence of subsequent leukemia in patients with transient myeloproliferative disorder treated with this regimen. Determine the predictive risk factors for developing subsequent leukemia in patients with transient myeloproliferative disorder treated with this regimen. OUTLINE: This is a multicenter study. Group I: Patients are observed if their transient myeloproliferative disorder (TMD) does not require intervention. Patients who require therapy for TMD undergo leukapheresis or exchange transfusion for up to 3 consecutive days. If the TMD does not resolve or there is significant organ involvement, patients receive low-dose cytarabine IV continuously on days 0-4. Treatment repeats at least every 2 weeks for up to 4 courses. Patients who experience a recurrence of TMD at least 8 weeks after resolution or have refractory disease may proceed to group II for further treatment. Group II (closed to accrual as of 6/24/04 except for patients first enrolled in group I): Patients receive induction therapy comprising cytarabine IV continuously, daunorubicin IV continuously, and oral thioguanine twice daily on days 0-3. Treatment repeats every 28 days for 4 courses. Patients with no CNS disease at diagnosis receive cytarabine intrathecally (IT) on day 0. Patients with CNS disease at diagnosis receive cytarabine IT on days 0, 5, and 7. If CNS disease persists on day 7, patients receive up to 6 courses of cytarabine IT, hydrocortisone IT, and methotrexate IT, twice weekly beginning on day 10. Patients who achieve remission after induction therapy receive 2 courses of intensification therapy, for approximately 4 months. During the first course, patients receive cytarabine IV over 3 hours twice daily on days 0, 1, 7, and 8. Patients also receive asparaginase intramuscularly on days 1 and 8. The second course of therapy comprises CNS prophylaxis. Patients with no CNS disease at diagnosis or whose CNS disease resolved by day 7 of induction therapy receive cytarabine IT on days 0, 7, and 14. Patients with persistent CNS disease on day 7 of induction therapy receive cytarabine IT, hydrocortisone IT, and methotrexate IT on days 0, 7, and 14. Patients are followed monthly for 18 months, every 3 months for 1 year, every 6 months for 2.5 years, and then annually thereafter. PROJECTED ACCRUAL: A total of 70 patients with acute myeloid leukemia or myelodysplastic syndromes will be accrued for this study within 3.2 years. A total of 88 patients with transient myeloproliferative disorder who enter remission will be accrued for this study within 5 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms

Keywords

childhood myelodysplastic syndromes, untreated childhood acute myeloid leukemia and other myeloid malignancies, childhood acute myeloblastic leukemia without maturation (M1), childhood acute myeloblastic leukemia with maturation (M2), childhood acute myelomonocytic leukemia (M4), childhood acute erythroleukemia (M6), childhood acute megakaryocytic leukemia (M7), refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, de novo myelodysplastic syndromes, childhood acute minimally differentiated myeloid leukemia (M0), childhood acute monocytic leukemia (M5b), childhood acute monoblastic leukemia (M5a), myelodysplastic/myeloproliferative neoplasm, unclassifiable, juvenile myelomonocytic leukemia, chronic myelomonocytic leukemia, secondary myelodysplastic syndromes

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Single Group Assignment

Masking

None (Open Label)

Allocation

Non-Randomized

Enrollment

254 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Arm A: TMD patients only

Arm Type

Experimental

Arm Description

Arm Title

Arm B: AML/MDS patients only

Arm Type

Experimental

Arm Description

Intervention Type

Drug

Intervention Name(s)

asparaginase

Other Intervention Name(s)

Elspar, Kidrolase, Crasnitin, Leunase, NSC #109229

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

cytarabine

Other Intervention Name(s)

cytosine arabinoside, AraC, Cytosar, NSC #063878

Intervention Description

Given IT

Intervention Type

Drug

Intervention Name(s)

daunorubicin hydrochloride

Other Intervention Name(s)

daunomycin, DNR, Cerubidine, NSC #82151

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

methotrexate

Other Intervention Name(s)

MTX, amethopterin, NSC #000740

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

therapeutic hydrocortisone

Other Intervention Name(s)

Cortef, Solu-cortef, NSC #010483

Intervention Description

Given IT

Intervention Type

Drug

Intervention Name(s)

thioguanine

Other Intervention Name(s)

6-thioguanine, 6-TG, NSC # 000752

Intervention Description

Given IV

Primary Outcome Measure Information:

Title

Event Free Survival

Time Frame

Length of study

10. Eligibility

Sex

All

Maximum Age & Unit of Time

21 Years

Accepts Healthy Volunteers

Eligibility Criteria

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Alan S. Gamis, MD, MPH

Organizational Affiliation

Children's Mercy Hospital Kansas City

Official's Role

Study Chair

Facility Information:

Facility Name

University of Alabama at Birmingham Comprehensive Cancer Center

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35233

Country

United States

Facility Name

University of South Alabama Cancer Research Institute

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36604

Country

United States

Facility Name

Phoenix Children's Hospital

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85016-7710

Country

United States

Facility Name

Arizona Cancer Center at University of Arizona Health Sciences Center

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85724

Country

United States

Facility Name

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72205

Country

United States

Facility Name

Southern California Permanente Medical Group

City

Downey

State/Province

California

ZIP/Postal Code

90242

Country

United States

Facility Name

City of Hope Comprehensive Cancer Center

City

Duarte

State/Province

California

ZIP/Postal Code

91010-3000

Country

United States

Facility Name

Rebecca and John Moores UCSD Cancer Center

City

La Jolla

State/Province

California

ZIP/Postal Code

92093-0658

Country

United States

Facility Name

Loma Linda University Cancer Institute at Loma Linda University Medical Center

City

Loma Linda

State/Province

California

ZIP/Postal Code

92354

Country

United States

Facility Name

Jonathan Jaques Children's Cancer Center at Miller Children's Hospital

City

Long Beach

State/Province

California

ZIP/Postal Code

90801-1428

Country

United States

Facility Name

Children's Hospital Los Angeles

City

Los Angeles

State/Province

California

ZIP/Postal Code

90027-0700

Country

United States

Facility Name

Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center

City

Los Angeles

State/Province

California

ZIP/Postal Code

90048

Country

United States

Facility Name

Jonsson Comprehensive Cancer Center, UCLA

City

Los Angeles

State/Province

California

ZIP/Postal Code

90095-1781

Country

United States

Facility Name

Children's Hospital Central California

City

Madera

State/Province

California

ZIP/Postal Code

93638-8762

Country

United States

Facility Name

Children's Hospital and Research Center at Oakland

City

Oakland

State/Province

California

ZIP/Postal Code

94609-1809

Country

United States

Facility Name

Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center

City

Orange

State/Province

California

ZIP/Postal Code

92868

Country

United States

Facility Name

Children's Hospital of Orange County

City

Orange

State/Province

California

ZIP/Postal Code

92868

Country

United States

Facility Name

Lucile Packard Children's Hospital at Stanford University Medical Center

City

Palo Alto

State/Province

California

ZIP/Postal Code

94304

Country

United States

Facility Name

Sutter Cancer Center

City

Sacramento

State/Province

California

ZIP/Postal Code

95816

Country

United States

Facility Name

University of California Davis Cancer Center

City

Sacramento

State/Province

California

ZIP/Postal Code

95817

Country

United States

Facility Name

Kaiser Permanente Medical Center - Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95825

Country

United States

Facility Name

Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego

City

San Diego

State/Province

California

ZIP/Postal Code

92120

Country

United States

Facility Name

Children's Hospital and Health Center, San Diego

City

San Diego

State/Province

California

ZIP/Postal Code

92123-4282

Country

United States

Facility Name

UCSF Comprehensive Cancer Center

City

San Francisco

State/Province

California

ZIP/Postal Code

94115

Country

United States

Facility Name

Santa Barbara Cottage Hospital

City

Santa Barbara

State/Province

California

ZIP/Postal Code

93102

Country

United States

Facility Name

Kaiser Permanente Medical Center - Santa Clara

City

Santa Clara

State/Province

California

ZIP/Postal Code

95051-5386

Country

United States

Facility Name

David Grant Medical Center

City

Travis Air Force Base

State/Province

California

ZIP/Postal Code

94535

Country

United States

Facility Name

Children's Hospital of Denver

City

Denver

State/Province

Colorado

ZIP/Postal Code

80218-1088

Country

United States

Facility Name

Presbyterian - St. Luke's Medical Center

City

Denver

State/Province

Colorado

ZIP/Postal Code

80218

Country

United States

Facility Name

University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center

City

Farmington

State/Province

Connecticut

ZIP/Postal Code

06360-7106

Country

United States

Facility Name

Yale Comprehensive Cancer Center

City

New Haven

State/Province

Connecticut

ZIP/Postal Code

06520-8028

Country

United States

Facility Name

Alfred I. duPont Hospital for Children

City

Wilmington

State/Province

Delaware

ZIP/Postal Code

19899

Country

United States

Facility Name

Lombardi Cancer Center at Georgetown University Medical Center

City

Washington

State/Province

District of Columbia

ZIP/Postal Code

20007

Country

United States

Facility Name

Children's National Medical Center

City

Washington

State/Province

District of Columbia

ZIP/Postal Code

20010-2970

Country

United States

Facility Name

Walter Reed Army Medical Center

City

Washington

State/Province

District of Columbia

ZIP/Postal Code

20307-5001

Country

United States

Facility Name

Broward General Medical Center

City

Fort Lauderdale

State/Province

Florida

ZIP/Postal Code

33316

Country

United States

Facility Name

Children's Hospital of Southwest Florida

City

Fort Myers

State/Province

Florida

ZIP/Postal Code

33908

Country

United States

Facility Name

Shands Cancer Center at the University of Florida Health Science Center

City

Gainesville

State/Province

Florida

ZIP/Postal Code

32610-0296

Country

United States

Facility Name

Joe DiMaggio Children's Hospital at Memorial

City

Hollywood

State/Province

Florida

ZIP/Postal Code

33021

Country

United States

Facility Name

Nemours Children's Clinic

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32207

Country

United States

Facility Name

Jackson Memorial Hospital

City

Miami

State/Province

Florida

ZIP/Postal Code

33136

Country

United States

Facility Name

Miami Children's Hospital

City

Miami

State/Province

Florida

ZIP/Postal Code

33155

Country

United States

Facility Name

Baptist Hospital of Miami

City

Miami

State/Province

Florida

ZIP/Postal Code

33176-2197

Country

United States

Facility Name

Florida Hospital Cancer Institute

City

Orlando

State/Province

Florida

ZIP/Postal Code

32804

Country

United States

Facility Name

Nemours Children's Clinic-Orlando

City

Orlando

State/Province

Florida

ZIP/Postal Code

32806

Country

United States

Facility Name

Sacred Heart Children's Hospital

City

Pensacola

State/Province

Florida

ZIP/Postal Code

32504

Country

United States

Facility Name

All Children's Hospital

City

St. Petersburg

State/Province

Florida

ZIP/Postal Code

33701

Country

United States

Facility Name

St. Joseph's Children's Hospital

City

Tampa

State/Province

Florida

ZIP/Postal Code

33677-4227

Country

United States

Facility Name

St. Mary's Hospital

City

West Palm Beach

State/Province

Florida

ZIP/Postal Code

33407

Country

United States

Facility Name

AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish RiteCampus

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30342

Country

United States

Facility Name

MBCCOP-Medical College of Georgia Cancer Center

City

Augusta

State/Province

Georgia

ZIP/Postal Code

30912-4000

Country

United States

Facility Name

Medical Center of Central Georgia

City

Macon

State/Province

Georgia

ZIP/Postal Code

31201

Country

United States

Facility Name

Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

City

Savannah

State/Province

Georgia

ZIP/Postal Code

31405

Country

United States

Facility Name

Cancer Research Center of Hawaii

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

MBCCOP - Hawaii

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Tripler Army Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96859-5000

Country

United States

Facility Name

Mountain States Tumor Institute - Boise

City

Boise

State/Province

Idaho

ZIP/Postal Code

83712

Country

United States

Facility Name

University of Chicago Cancer Research Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60601

Country

United States

Facility Name

Rush University Medical Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612

Country

United States

Facility Name

University of Illinois Medical Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612

Country

United States

Facility Name

Children's Memorial Hospital - Chicago

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60614

Country

United States

Facility Name

Advocate Hope Children's Hospital

City

Oak Lawn

State/Province

Illinois

ZIP/Postal Code

60453

Country

United States

Facility Name

Lutheran General Cancer Care Center

City

Park Ridge

State/Province

Illinois

ZIP/Postal Code

60068-1174

Country

United States

Facility Name

Saint Jude Midwest Affiliate

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61637

Country

United States

Facility Name

Southern Illinois University School of Medicine

City

Springfield

State/Province

Illinois

ZIP/Postal Code

62794-9658

Country

United States

Facility Name

Riley Children Cancer Center at Riley Hospital for Children

City

Indianapolis

State/Province

Indiana

ZIP/Postal Code

46202-5225

Country

United States

Facility Name

St. Vincent Hospital and Health Care Center

City

Indianapolis

State/Province

Indiana

ZIP/Postal Code

46260

Country

United States

Facility Name

Blank Children's Hospital

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50308

Country

United States

Facility Name

John Stoddard Cancer Center at Iowa Methodist Medical Center

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50309

Country

United States

Facility Name

Holden Comprehensive Cancer Center at University of Iowa

City

Iowa City

State/Province

Iowa

ZIP/Postal Code

52242-1009

Country

United States

Facility Name

Wesley Medical Center

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Markey Cancer Center at University of Kentucky Chandler Medical Center

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40536-0284

Country

United States

Facility Name

Kosair Children's Hospital

City

Louisville

State/Province

Kentucky

ZIP/Postal Code

40202-3830

Country

United States

Facility Name

MBCCOP - LSU Health Sciences Center

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

Tulane Cancer Center at Tulane University Hospital and Clinic

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

Children's Hospital of New Orleans

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70118

Country

United States

Facility Name

Ochsner Clinic Foundation

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70121

Country

United States

Facility Name

Eastern Maine Medical Center

City

Bangor

State/Province

Maine

ZIP/Postal Code

04401

Country

United States

Facility Name

Maine Children's Cancer Program

City

Scarborough

State/Province

Maine

ZIP/Postal Code

04074-9308

Country

United States

Facility Name

Greenebaum Cancer Center at University of Maryland Medical Center

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21201-1595

Country

United States

Facility Name

Sinai Hospital of Baltimore

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21225

Country

United States

Facility Name

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21231-2410

Country

United States

Facility Name

Floating Hospital for Children

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02111

Country

United States

Facility Name

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02115

Country

United States

Facility Name

Baystate Regional Cancer Program at Baystate Medical Center

City

Springfield

State/Province

Massachusetts

ZIP/Postal Code

01107

Country

United States

Facility Name

University of Massachusetts Memorial Medical Center - University Campus

City

Worcester

State/Province

Massachusetts

ZIP/Postal Code

01655

Country

United States

Facility Name

University of Michigan Comprehensive Cancer Center

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48109-0914

Country

United States

Facility Name

Children's Hospital of Michigan

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48201

Country

United States

Facility Name

Josephine Ford Cancer Center at Henry Ford Hospital

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Facility Name

Van Elslander Cancer Center at St. John Hospital and Medical Center

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48236

Country

United States

Facility Name

Hurley Medical Center

City

Flint

State/Province

Michigan

ZIP/Postal Code

48503

Country

United States

Facility Name

Spectrum Health and DeVos Children's Hospital

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Bronson Methodist Hospital

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49007-5364

Country

United States

Facility Name

Breslin Cancer Center at Ingham Regional Medical Center

City

Lansing

State/Province

Michigan

ZIP/Postal Code

48910

Country

United States

Facility Name

CCOP - Beaumont

City

Royal Oak

State/Province

Michigan

ZIP/Postal Code

48073-6769

Country

United States

Facility Name

William Beaumont Hospital - Royal Oak

City

Royal Oak

State/Province

Michigan

ZIP/Postal Code

48073-6769

Country

United States

Facility Name

St. Mary's - Duluth Clinic Cancer Center

City

Duluth

State/Province

Minnesota

ZIP/Postal Code

55805

Country

United States

Facility Name

Children's Hospitals and Clinics - Minneapolis

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55404

Country

United States

Facility Name

Mayo Clinic Cancer Center

City

Rochester

State/Province

Minnesota

ZIP/Postal Code

55905

Country

United States

Facility Name

Children's Hospitals and Clinics - Minnesota

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55102

Country

United States

Facility Name

University of Mississippi Medical Center

City

Jackson

State/Province

Mississippi

ZIP/Postal Code

39216-4505

Country

United States

Facility Name

Children's Mercy Hospital

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64108

Country

United States

Facility Name

Cardinal Glennon Children's Hospital

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63104

Country

United States

Facility Name

St. Louis Children's Hospital

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63110

Country

United States

Facility Name

Children's Hospital of Omaha

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68114

Country

United States

Facility Name

UNMC Eppley Cancer Center at the University of Nebraska Medical Center

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68198-2168

Country

United States

Facility Name

Sunrise Hospital and Medical Center

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89109

Country

United States

Facility Name

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

City

Lebanon

State/Province

New Hampshire

ZIP/Postal Code

03756

Country

United States

Facility Name

Cancer Center at Hackensack University Medical Center

City

Hackensack

State/Province

New Jersey

ZIP/Postal Code

07601

Country

United States

Facility Name

Cancer Institute of New Jersey at Robert Wood Johnson University Hospital

City

New Brunswick

State/Province

New Jersey

ZIP/Postal Code

08903

Country

United States

Facility Name

Newark Beth Israel Medical Center

City

Newark

State/Province

New Jersey

ZIP/Postal Code

07112-2094

Country

United States

Facility Name

St. Joseph's Hospital and Medical Center

City

Paterson

State/Province

New Jersey

ZIP/Postal Code

07503

Country

United States

Facility Name

Valerie Fund Children's Center at Atlantic Health

City

Summit

State/Province

New Jersey

ZIP/Postal Code

07901

Country

United States

Facility Name

University of New Mexico Cancer Research and Treatment Center

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87131

Country

United States

Facility Name

Cancer Center of Albany Medical Center

City

Albany

State/Province

New York

ZIP/Postal Code

12208

Country

United States

Facility Name

Albert Einstein Clinical Cancer Center

City

Bronx

State/Province

New York

ZIP/Postal Code

10461

Country

United States

Facility Name

Brooklyn Hospital Center

City

Brooklyn

State/Province

New York

ZIP/Postal Code

11201-5493

Country

United States

Facility Name

SUNY Downstate Medical Center

City

Brooklyn

State/Province

New York

ZIP/Postal Code

11203

Country

United States

Facility Name

Brookdale University Hospital and Medical Center

City

Brooklyn

State/Province

New York

ZIP/Postal Code

11212

Country

United States

Facility Name

Comprehensive Cancer Center at Maimonides Medical Center

City

Brooklyn

State/Province

New York

ZIP/Postal Code

11219

Country

United States

Facility Name

Roswell Park Cancer Institute

City

Buffalo

State/Province

New York

ZIP/Postal Code

14263-0001

Country

United States

Facility Name

North Shore University Hospital

City

Manhasset

State/Province

New York

ZIP/Postal Code

11030

Country

United States

Facility Name

Schneider Children's Hospital

City

New Hyde Park

State/Province

New York

ZIP/Postal Code

11042

Country

United States

Facility Name

Memorial Sloan-Kettering Cancer Center

City

New York

State/Province

New York

ZIP/Postal Code

10021

Country

United States

Facility Name

New York Weill Cornell Cancer Center at Cornell University

City

New York

State/Province

New York

ZIP/Postal Code

10021

Country

United States

Facility Name

Mount Sinai School of Medicine

City

New York

State/Province

New York

ZIP/Postal Code

10029

Country

United States

Facility Name

Herbert Irving Comprehensive Cancer Center at Columbia University

City

New York

State/Province

New York

ZIP/Postal Code

10032

Country

United States

Facility Name

James P. Wilmot Cancer Center at University of Rochester Medical Center

City

Rochester

State/Province

New York

ZIP/Postal Code

14642

Country

United States

Facility Name

Long Island Cancer Center at Stony Brook University Hospital

City

Stony Brook

State/Province

New York

ZIP/Postal Code

11794

Country

United States

Facility Name

University Hospital at State University of New York - Upstate Medical University

City

Syracuse

State/Province

New York

ZIP/Postal Code

13210

Country

United States

Facility Name

New York Medical College

City

Valhalla

State/Province

New York

ZIP/Postal Code

10595

Country

United States

Facility Name

Mission Hospitals

City

Asheville

State/Province

North Carolina

ZIP/Postal Code

28801

Country

United States

Facility Name

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27599-7295

Country

United States

Facility Name

Blumenthal Cancer Center at Carolinas Medical Center

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28232-2861

Country

United States

Facility Name

Presbyterian Healthcare

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28233

Country

United States

Facility Name

Duke Comprehensive Cancer Center

City

Durham

State/Province

North Carolina

ZIP/Postal Code

27710

Country

United States

Facility Name

Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina

City

Greenville

State/Province

North Carolina

ZIP/Postal Code

27858-4354

Country

United States

Facility Name

Comprehensive Cancer Center at Wake Forest University

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27157-1081

Country

United States

Facility Name

Dakota Cancer Institute at Innovis Health - Dakota Clinic

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58103-4940

Country

United States

Facility Name

Children's Hospital Medical Center of Akron

City

Akron

State/Province

Ohio

ZIP/Postal Code

44308

Country

United States

Facility Name

Cincinnati Children's Hospital Medical Center

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45229-3039

Country

United States

Facility Name

Ireland Cancer Center

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44106-5065

Country

United States

Facility Name

Cleveland Clinic Taussig Cancer Center

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44195

Country

United States

Facility Name

Children's Hospital of Columbus

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43205-2696

Country

United States

Facility Name

Children's Medical Center - Dayton

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45404

Country

United States

Facility Name

Toledo Children's Hospital

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43601

Country

United States

Facility Name

St. Vincent Mercy Medical Center

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43608

Country

United States

Facility Name

Forum Health-Tod Childrens Hospital

City

Youngstown

State/Province

Ohio

ZIP/Postal Code

44501

Country

United States

Facility Name

Children's Hospital at Oklahoma University Medical Center

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73104

Country

United States

Facility Name

CCOP - Oklahoma

City

Tulsa

State/Province

Oklahoma

ZIP/Postal Code

74136

Country

United States

Facility Name

Natalie Warren Bryant Cancer Center

City

Tulsa

State/Province

Oklahoma

ZIP/Postal Code

74136

Country

United States

Facility Name

CCOP - Columbia River Oncology Program

City

Portland

State/Province

Oregon

ZIP/Postal Code

97225

Country

United States

Facility Name

Legacy Emanuel Hospital and Health Center & Children's Hospital

City

Portland

State/Province

Oregon

ZIP/Postal Code

97227

Country

United States

Facility Name

Doernbecher Children's Hospital at Oregon Health & Science University

City

Portland

State/Province

Oregon

ZIP/Postal Code

97239-3098

Country

United States

Facility Name

Geisinger Medical Center

City

Danville

State/Province

Pennsylvania

ZIP/Postal Code

17822-1320

Country

United States

Facility Name

Penn State Cancer Institute at Milton S. Hershey Medical Center

City

Hershey

State/Province

Pennsylvania

ZIP/Postal Code

17033

Country

United States

Facility Name

Children's Hospital of Philadelphia

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19104

Country

United States

Facility Name

St. Christopher's Hospital for Children

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19134-1095

Country

United States

Facility Name

Children's Hospital of Pittsburgh

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15213-2583

Country

United States

Facility Name

Rhode Island Hospital

City

Providence

State/Province

Rhode Island

ZIP/Postal Code

02903

Country

United States

Facility Name

Hollings Cancer Center at Medical University of South Carolina

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29425-0721

Country

United States

Facility Name

Palmetto Health South Carolina Cancer Center

City

Columbia

State/Province

South Carolina

ZIP/Postal Code

29203

Country

United States

Facility Name

Children's Hospital of Greenville Hospital System

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Avera Cancer Institute

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57105-1080

Country

United States

Facility Name

Sioux Valley Hospital at University of South Dakota Medical Center

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57117-5039

Country

United States

Facility Name

East Tennessee State University Cancer Center at Johnson City Medical Center

City

Johnson City

State/Province

Tennessee

ZIP/Postal Code

37604

Country

United States

Facility Name

East Tennessee Children's Hospital

City

Knoxville

State/Province

Tennessee

ZIP/Postal Code

37901

Country

United States

Facility Name

St. Jude Children's Research Hospital

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38105-2794

Country

United States

Facility Name

Vanderbilt Children's Hospital

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37232-6310

Country

United States

Facility Name

Texas Tech University Health Sciences Center School of Medicine

City

Amarillo

State/Province

Texas

ZIP/Postal Code

79106

Country

United States

Facility Name

Children's Hospital of Austin

City

Austin

State/Province

Texas

ZIP/Postal Code

78701

Country

United States

Facility Name

Medical City Dallas Hospital

City

Dallas

State/Province

Texas

ZIP/Postal Code

75230

Country

United States

Facility Name

Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas

City

Dallas

State/Province

Texas

ZIP/Postal Code

75390-9063

Country

United States

Facility Name

Cook Children's Medical Center - Fort Worth

City

Fort Worth

State/Province

Texas

ZIP/Postal Code

76104

Country

United States

Facility Name

University of Texas Medical Branch

City

Galveston

State/Province

Texas

ZIP/Postal Code

77555-0361

Country

United States

Facility Name

University of Texas - MD Anderson Cancer Center

City

Houston

State/Province

Texas

ZIP/Postal Code

77030-4009

Country

United States

Facility Name

Baylor College of Medicine

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Facility Name

San Antonio Military Pediatric Cancer and Blood Disorders Center

City

Lackland Air Force Base

State/Province

Texas

ZIP/Postal Code

78236

Country

United States

Facility Name

Covenant Children's Hospital

City

Lubbock

State/Province

Texas

ZIP/Postal Code

79410

Country

United States

Facility Name

University of Texas Health Science Center at San Antonio

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78207

Country

United States

Facility Name

MBCCOP - South Texas Pediatrics

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229-3900

Country

United States

Facility Name

Methodist Cancer Center at Methodist Specialty and Transplant Hospital

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229-3902

Country

United States

Facility Name

CCOP - Scott and White Hospital

City

Temple

State/Province

Texas

ZIP/Postal Code

76508

Country

United States

Facility Name

Center for Cancer Prevention and Care at Scott and White Clinic

City

Temple

State/Province

Texas

ZIP/Postal Code

76508

Country

United States

Facility Name

Huntsman Cancer Institute

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84112

Country

United States

Facility Name

Vermont Cancer Center at University of Vermont

City

Burlington

State/Province

Vermont

ZIP/Postal Code

05401-3498

Country

United States

Facility Name

Cancer Center at the University of Virginia

City

Charlottesville

State/Province

Virginia

ZIP/Postal Code

22908

Country

United States

Facility Name

Inova Fairfax Hospital

City

Falls Church

State/Province

Virginia

ZIP/Postal Code

22042-3300

Country

United States

Facility Name

Children's Hospital of the King's Daughters

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23507

Country

United States

Facility Name

Naval Medical Center, Portsmouth

City

Portsmouth

State/Province

Virginia

ZIP/Postal Code

23708-5100

Country

United States

Facility Name

Massey Cancer Center at Virginia Commonwealth University

City

Richmond

State/Province

Virginia

ZIP/Postal Code

23298-0121

Country

United States

Facility Name

Carilion Medical Center for Children

City

Roanoke

State/Province

Virginia

ZIP/Postal Code

24029

Country

United States

Facility Name

Children's Hospital and Regional Medical Center - Seattle

City

Seattle

State/Province

Washington

ZIP/Postal Code

98105

Country

United States

Facility Name

Fred Hutchinson Cancer Research Center

City

Seattle

State/Province

Washington

ZIP/Postal Code

98109-1024

Country

United States

Facility Name

Group Health Central Hospital

City

Seattle

State/Province

Washington

ZIP/Postal Code

98112

Country

United States

Facility Name

Deaconess Medical Center

City

Spokane

State/Province

Washington

ZIP/Postal Code

99210-0248

Country

United States

Facility Name

Mary Bridge Children's Hospital and Health Center

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98415-0299

Country

United States

Facility Name

Madigan Army Medical Center

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98431-5000

Country

United States

Facility Name

West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division

City

Charleston

State/Province

West Virginia

ZIP/Postal Code

25302

Country

United States

Facility Name

Cabell Huntington Hospital

City

Huntington

State/Province

West Virginia

ZIP/Postal Code

25701

Country

United States

Facility Name

West Virginia University Hospitals

City

Morgantown

State/Province

West Virginia

ZIP/Postal Code

26506-9300

Country

United States

Facility Name

Bellin Memorial Hospital

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54301

Country

United States

Facility Name

CCOP - St. Vincent Hospital Cancer Center, Green Bay

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54301

Country

United States

Facility Name

St. Vincent Hospital

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54307-9070

Country

United States

Facility Name

Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center

City

La Crosse

State/Province

Wisconsin

ZIP/Postal Code

54601

Country

United States

Facility Name

University of Wisconsin Comprehensive Cancer Center

City

Madison

State/Province

Wisconsin

ZIP/Postal Code

53792-6164

Country

United States

Facility Name

Marshfield Clinic

City

Marshfield

State/Province

Wisconsin

ZIP/Postal Code

54449-5772

Country

United States

Facility Name

CCOP - Marshfield Clinic Research Foundation

City

Marshfield

State/Province

Wisconsin

ZIP/Postal Code

54449

Country

United States

Facility Name

Midwest Children's Cancer Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53226

Country

United States

Facility Name

Sydney Children's Hospital

City

Randwick

State/Province

New South Wales

ZIP/Postal Code

2031

Country

Australia

Facility Name

Children's Hospital at Westmead

City

Westmead

State/Province

New South Wales

ZIP/Postal Code

2145

Country

Australia

Facility Name

Royal Children's Hospital

City

Brisbane

State/Province

Queensland

ZIP/Postal Code

4029

Country

Australia

Facility Name

Women's and Children's Hospital

City

North Adelaide

State/Province

South Australia

ZIP/Postal Code

5006

Country

Australia

Facility Name

Royal Children's Hospital

City

Parkville

State/Province

Victoria

ZIP/Postal Code

3052

Country

Australia

Facility Name

Princess Margaret Hospital for Children

City

Perth

State/Province

Western Australia

ZIP/Postal Code

6001

Country

Australia

Facility Name

Alberta Children's Hospital

City

Calgary

State/Province

Alberta

ZIP/Postal Code

T2T 5C7

Country

Canada

Facility Name

Cross Cancer Institute

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T6G 1Z2

Country

Canada

Facility Name

British Columbia Children's Hospital

City

Vancouver

State/Province

British Columbia

ZIP/Postal Code

V6H 3V4

Country

Canada

Facility Name

CancerCare Manitoba

City

Winnipeg

State/Province

Manitoba

ZIP/Postal Code

R3E 0V9

Country

Canada

Facility Name

Janeway Children's Health and Rehabilitation Centre

City

St. John's

State/Province

Newfoundland and Labrador

ZIP/Postal Code

A1B 3V6

Country

Canada

Facility Name

IWK Health Centre

City

Halifax

State/Province

Nova Scotia

ZIP/Postal Code

B3J 3G9

Country

Canada

Facility Name

McMaster Children's Hospital at Hamilton Health Sciences

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8N 3Z5

Country

Canada

Facility Name

Children's Hospital of Western Ontario

City

London

State/Province

Ontario

ZIP/Postal Code

N6C 2V5

Country

Canada

Facility Name

Children's Hospital of Eastern Ontario

City

Ottawa

State/Province

Ontario

ZIP/Postal Code

K1H 8L1

Country

Canada

Facility Name

Hospital for Sick Children

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5G 1X8

Country

Canada

Facility Name

McGill University Health Center - Montreal Children's Hospital

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3G 1A4

Country

Canada

Facility Name

Hopital Sainte Justine

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3T 1C5

Country

Canada

Facility Name

Centre de Recherche du Centre Hospitalier de l'Universite Laval

City

Sainte Foy

State/Province

Quebec

ZIP/Postal Code

GIV 4G2

Country

Canada

Facility Name

Allan Blair Cancer Centre at Pasqua Hospital

City

Regina

State/Province

Saskatchewan

ZIP/Postal Code

S4T 7T1

Country

Canada

Facility Name

Saskatoon Cancer Centre

City

Saskatoon

State/Province

Saskatchewan

ZIP/Postal Code

S7N 4H4

Country

Canada

Facility Name

Academisch Ziekenhuis Groningen

City

Groningen

ZIP/Postal Code

9700 RB

Country

Netherlands

Facility Name

Starship Children's Hospital

City

Auckland

Country

New Zealand

Facility Name

Puerto Rico Cancer Center at University of Puerto Rico - Medical Sciences Campus

City

San Juan

ZIP/Postal Code

00936-5067

Country

Puerto Rico

Facility Name

San Jorge Childrens Hospital

City

Santurce

ZIP/Postal Code

00912

Country

Puerto Rico

Facility Name

Swiss Pediatric Oncology Group Bern

City

Bern

ZIP/Postal Code

CH 3010

Country

Switzerland

Facility Name

Swiss Pediatric Oncology Group Geneva

City

Geneva

ZIP/Postal Code

CH 1211

Country

Switzerland

Facility Name

Swiss Pediatric Oncology Group Lausanne

City

Lausanne

ZIP/Postal Code

CH 1011

Country

Switzerland

12. IPD Sharing Statement

Citations:

Citation

Perentesis JP, Alonzo TA, Gerbing R, et al.: Polymorphism in folate metabolism and outcomes of therapy in children with AML with and without Down Syndrome. [Abstract] Blood 102 (11 Pt 1): A-479, 2003.

Results Reference

background

PubMed Identifier

22392565

Citation

Sorrell AD, Alonzo TA, Hilden JM, Gerbing RB, Loew TW, Hathaway L, Barnard D, Taub JW, Ravindranath Y, Smith FO, Arceci RJ, Woods WG, Gamis AS. Favorable survival maintained in children who have myeloid leukemia associated with Down syndrome using reduced-dose chemotherapy on Children's Oncology Group trial A2971: a report from the Children's Oncology Group. Cancer. 2012 Oct 1;118(19):4806-14. doi: 10.1002/cncr.27484. Epub 2012 Mar 5.

Results Reference

result

PubMed Identifier

21849481

Citation

Gamis AS, Alonzo TA, Gerbing RB, Hilden JM, Sorrell AD, Sharma M, Loew TW, Arceci RJ, Barnard D, Doyle J, Massey G, Perentesis J, Ravindranath Y, Taub J, Smith FO. Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971. Blood. 2011 Dec 22;118(26):6752-9; quiz 6996. doi: 10.1182/blood-2011-04-350017. Epub 2011 Aug 17.

Results Reference

result

Citation

Gamis AS, Alonzo TA, Hilden JM, et al.: Outcome of Down syndrome (DS) children with acute myeloid leukemia (AML) or myelodysplasia (MDS) treated with a uniform prospective clinical trial initial report of the COG trial A2971. [Abstract] Blood 108 (11): A-15, 2006.

Results Reference

result

Citation

Sharma M, Alonzo TA, Sorrell A, et al.: Uniform approach better defines natural history of transient myeloproliferative disorder (TMD) in Down syndrome (DS) neonates: outcomes from Children's Oncology Group (COG) study A2971. [Abstract] Blood 108 (11): A-376, 2006.

Results Reference

result

Learn more about this trial

Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome

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