Carboplatin Plus Paclitaxel With or Without Continued Low-Dose Paclitaxel in Treating Patients With Early-Stage Ovarian Cancer
Ovarian Cancer
About this trial
This is an interventional treatment trial for Ovarian Cancer focused on measuring stage I ovarian epithelial cancer, stage II ovarian epithelial cancer, ovarian undifferentiated adenocarcinoma, ovarian mixed epithelial carcinoma, ovarian serous cystadenocarcinoma, ovarian mucinous cystadenocarcinoma, ovarian endometrioid adenocarcinoma, ovarian clear cell cystadenocarcinoma, Brenner tumor
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed ovarian epithelial cancer of one of the following histologic cell types: Serous adenocarcinoma Malignant Brenner's tumor Mucinous adenocarcinoma Endometrioid Adenocarcinoma Clear cell adenocarcinoma Undifferentiated carcinoma Transitional cell Mixed epithelial carcinoma Adenocarcinoma - not otherwise specified Meets 1 of the following criteria: Stage Ia or Ib, grade 3 or clear cell Stage Ic or II, all grades/histologies Complete surgical staging No tumors of low malignant potential (borderline tumors) PATIENT CHARACTERISTICS: Age: Not specified Performance status: GOG 0-3 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm^3 Platelet count at least 100,000/mm^3 Hepatic: Bilirubin no greater than 1.5 times normal Alkaline phosphatase no greater than 3 times normal SGOT no greater than 3 times normal Renal: Creatinine no greater than 2.0 mg/dL Other: No other invasive malignancies within the past 5 years except nonmelanoma skin cancer No major systemic medical illness expected to affect survival Body surface area no greater than 2.0 PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: See Disease Characteristics Other: No prior treatment for this malignancy except surgical staging No prior anticancer therapy that would preclude study participation
Sites / Locations
- University of Alabama at Birmingham Comprehensive Cancer Center
- Banner Thunderbird Medical Center
- Banner Good Samaritan Medical Center
- CCOP - Western Regional, Arizona
- Highlands Oncology Group - Fayetteville
- Washington Regional Medical Center
- Alta Bates Comprehensive Cancer Center
- Peninsula Medical Center
- Marin Cancer Institute at Marin General Hospital
- Sutter Health - Western Division Cancer Research Group
- Todd Cancer Institute at Long Beach Memorial Medical Center
- Kaiser Permanente Medical Center - Los Angeles
- Jonsson Comprehensive Cancer Center at UCLA
- Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
- University of California Davis Cancer Center
- California Pacific Medical Center - California Campus
- Torrance Memorial Medical Center
- Colorado Gynecologic Oncology Group P.C.
- North Colorado Medical Center
- McKee Medical Center
- Helen and Harry Gray Cancer Center at Hartford Hospital
- CCOP - Christiana Care Health Services
- University of Miami Sylvester Comprehensive Cancer Center
- Florida Hospital Cancer Institute at Florida Hospital Orlando
- H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
- Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
- Rush-Copley Cancer Care Center
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- University of Illinois Cancer Center
- University of Chicago Cancer Research Center
- Evanston Northwestern Healthcare - Evanston Hospital
- Hinsdale Hematology Oncology Associates
- Joliet Oncology-Hematology Associates, Limited - West
- Carle Cancer Center at Carle Foundation Hospital
- CCOP - Carle Cancer Center
- Elkhart General Hospital
- Indiana University Cancer Center
- Howard Community Hospital at Howard Regional Health System
- Center for Cancer Therapy at LaPorte Hospital and Health Services
- Saint Anthony Memorial Health Centers
- CCOP - Northern Indiana CR Consortium
- Memorial Hospital of South Bend
- Saint Joseph Regional Medical Center
- Holden Comprehensive Cancer Center at University of Iowa
- Cancer Center of Kansas, PA - Chanute
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, PA - El Dorado
- Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
- Cancer Center of Kansas, PA - Kingman
- Southwest Medical Center
- Cancer Center of Kansas, PA - Newton
- Cancer Center of Kansas, PA - Parsons
- Cancer Center of Kansas, PA - Pratt
- Cancer Center of Kansas, PA - Salina
- Cancer Center of Kansas, PA - Wellington
- Associates in Womens Health, PA - North Review
- Cancer Center of Kansas, PA - Medical Arts Tower
- Cancer Center of Kansas, PA - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Cancer Center of Kansas, PA - Winfield
- Cancer Resource Center at King's Daughters Medical Center
- Markey Cancer Center at University of Kentucky Chandler Medical Center
- James Graham Brown Cancer Center at University of Louisville
- Tulane Cancer Center
- Woman's Hospital
- Greater Baltimore Medical Center Cancer Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Tufts-NEMC Cancer Center
- Baystate Regional Cancer Program at D'Amour Center for Cancer Care
- UMASS Memorial Cancer Center - University Campus
- Barbara Ann Karmanos Cancer Institute
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
- University of Minnesota Medical Center & Children's Hospital - Fairview
- University of Mississippi Medical Center
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- CCOP - Kansas City
- Siteman Cancer Center at Barnes-Jewish Hospital
- St. John's Regional Health Center
- Hulston Cancer Center at Cox Medical Center South
- Cancer Resource Center - Lincoln
- CCOP - Missouri Valley Cancer Consortium
- Methodist Cancer Center at Methodist Hospital - Omaha
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
- Cancer Institute of New Jersey at Cooper - Voorhees
- Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- University of New Mexico Cancer Research and Treatment Center
- SUNY Downstate Medical Center
- Roswell Park Cancer Institute
- NYU Cancer Institute at New York University Medical Center
- Stony Brook University Cancer Center
- Randolph Hospital
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
- Blumenthal Cancer Center at Carolinas Medical Center
- Duke Comprehensive Cancer Center
- Moses Cone Regional Cancer Center at Wesley Long Community Hospital
- Gynecologic Oncology Network
- Leo W. Jenkins Cancer Center at ECU Medical School
- FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
- Annie Penn Cancer Center
- Wake Forest University Comprehensive Cancer Center
- Bismarck Cancer Center
- Cancer Care Center at Medcenter One Hospital
- Mid Dakota Clinic, PC
- St. Alexius Medical Center
- McDowell Cancer Center at Akron General Medical Center
- Aultman Hospital Cancer Center at Aultman Health Foundation
- Case Comprehensive Cancer Center
- MetroHealth's Cancer Care Center at MetroHealth Medical Center
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
- Riverside Methodist Hospital Cancer Care
- Hillcrest Cancer Center at Hillcrest Hospital
- Lake/University Ireland Cancer Center
- OU Cancer Institute
- Oregon Health & Science University Cancer Institute
- Rosenfeld Cancer Center at Abington Memorial Hospital
- Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
- Geisinger Medical Center
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Abramson Cancer Center of the University of Pennsylvania
- Joan Karnell Cancer Center at Pennsylvania Hospital
- Fox Chase Cancer Center - Philadelphia
- Fox Chase Cancer Center CCOP Research Base
- UPMC Cancer Center at Magee-Womens Hospital
- Reading Hospital and Medical Center
- Geisinger Medical Group - Scenery Park
- Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
- Sioux Valley Hospital and University of South Dakota Medical Center
- Baptist Regional Cancer Center at Baptist Hospital of East Tennessee
- Baptist Centers for Cancer Care
- Harrington Cancer Center
- Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
- Brooke Army Medical Center
- University of Texas Medical Branch
- Fletcher Allen Health Care - University Health Center Campus
- Bon Secours Cancer Institute at St. Mary's Hospital
- Virginia Commonwealth University Massey Cancer Center
- Carilion Gynecologic Oncology Associates
- Marshfield Clinic - Marshfield Center
- Marshfield Clinic - Indianhead Center
- Kagoshima City Hospital
- Kobe Medical Center
- Shikoku Cancer Center
- National Kyushu Cancer Center
- Tohoku University Graduate School of Medicine
- National Cancer Center Hospital
- Tottori University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Carboplatin, paclitaxel, low dose paclitaxel
Carboplatin, paclitaxel
carboplatin, paclitaxel followed by low dose paclitaxel 4 weeks later
carboplatin, paclitaxel