Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
Anal Cancer
About this trial
This is an interventional treatment trial for Anal Cancer focused on measuring stage II anal cancer, stage III anal cancer, squamous cell carcinoma of the anus, cloacogenic carcinoma of the anus, basaloid carcinoma of the anus
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven nonmetastatic anal cancer Anal/rectal junction OR Anal/cutaneous junction with the majority of the tumor in the anal canal, above the junction Epidermoid cancer (well-differentiated, fairly differentiated, or basaloid) OR Cloacogenic cancer Stage II or III T2 at least 4 cm OR T3 OR T4, N0-3, M0 OR T1, N1-3 OR T2 (less than 4 cm), N1-3 Tumors at least 4 cm in greatest dimension and/or tumors with lymph node invasion must be nonmetastatic by ultrasound No prior surgery to remove tumor PATIENT CHARACTERISTICS: Age: 80 and under Performance status: WHO 0 or 1 Life expectancy: Not specified Hematopoietic: WBC at least 2,000/mm^3 Platelet count at least 100,000/mm^3 Hemoglobin at least 11 g/dL (transfusion allowed) Hepatic: Not specified Renal: Creatinine no greater than 1.5 mg/dL Cardiovascular: No cardiac condition contraindicating use of fluorouracil Other: No prior malignancy within 5 years except squamous cell or basal cell skin cancer or carcinoma in situ of the cervix or breast No other serious medical or psychological condition No serious immunosuppression PRIOR CONCURRENT THERAPY: Biologic therapy: No prior biologic therapy Chemotherapy: No prior chemotherapy Endocrine therapy: No prior endocrine therapy Radiotherapy: No prior pelvic or inguinal radiotherapy Surgery: See Disease Characteristics No prior definitive colostomy
Sites / Locations
- Centre Paul Papin
- Institut Sainte Catherine
- Institut Bergonie
- CHU Ambroise Pare
- C.H. Bourg En Bresse
- Centre Regional Francois Baclesse
- Centre Hospitalier
- Hopital Louis Pasteur
- Centre Hospitalier Universitaire Henri Mondor
- Centre de Lutte Contre le Cancer Georges-Francois Leclerc
- Centre Hospitalier Departemental
- Centre Oscar Lambret
- Centre Hospital Regional Universitaire de Limoges
- Centre Leon Berard
- Institut J. Paoli and I. Calmettes
- CHU de la Timone
- Hopital Clinique Claude Bernard
- Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
- Centre Hospitalier de Mulhouse
- Centre D'Oncologie De Gentilly
- Centre Regional Rene Gauducheau
- Centre Catherine de Sienne
- Centre Antoine Lacassagne
- CHR D'Orleans - Hopital de la Source
- Hopital Europeen Georges Pompidou
- Hopital Bichat - Claude Bernard
- Hopital Robert Debre
- Institut Curie - Section Medicale
- Hopital Saint-Louis
- CHU Pitie-Salpetriere
- Hopital Tenon
- Hopital Jean Bernard
- Clinique Ste - Marie
- Institut Jean Godinot
- Centre Eugene Marquis
- Hopital Charles Nicolle
- Centre Henri Becquerel
- Clinique Armoricaine De Radiologie
- Centre Rene Huguenin
- Centre Hospitalier General de Saint Nazaire
- Clinique de l'Orangerie
- Centre Paul Strauss
- Centre Hospitalier Regional Metz Thionville
- Institut Claudius Regaud
- Clinique Fleming
- Nouvelle Clinique Generale
- Centre Alexis Vautrin
- Institut Gustave Roussy