Radiolabeled Monoclonal Antibody, Cyclophosphamide, and Total Body Irradiation Followed By Donor Stem Cell Transplantation in Treating Patients With Advanced Acute Myeloid Leukemia
Leukemia
About this trial
This is an interventional treatment trial for Leukemia focused on measuring recurrent childhood acute myeloid leukemia, recurrent adult acute myeloid leukemia, secondary acute myeloid leukemia, adult acute myeloid leukemia with t(8;21)(q22;q22), adult acute myeloid leukemia with t(16;16)(p13;q22), adult acute myeloid leukemia with inv(16)(p13;q22), adult acute myeloid leukemia with 11q23 (MLL) abnormalities, adult acute myeloid leukemia with t(15;17)(q22;q12)
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of 1 of the following: Acute myeloid leukemia (AML) beyond first remission OR with primary refractory disease AML that has transformed from myelodysplastic syndromes, if induction chemotherapy not recommended Documented CD45 expression in patients with relapsed disease Not needed for patients in remission Circulating blast count less than 10,000/mm^3 (may be controlled with hydroxyurea or similar agent) PATIENT CHARACTERISTICS: Age 2 to 55 Performance status Not specified Life expectancy More than 60 days Hematopoietic See Disease Characteristics Hepatic Bilirubin less than 1.5 mg/dL (unless bilirubin is determined by the gastroenterology service to be predominantly unconjugated [indirect] as the result of possible hemolysis) AST less than 1.5 times upper limit of normal (ULN) Renal Creatinine less than 2.0 mg/dL OR less than 1.5 times ULN for age Other Not pregnant or nursing Fertile patients must use effective contraception No major infection No circulating antibodies to mouse immunoglobulins HIV negative Able to tolerate diagnostic or therapeutic procedures (e.g., radiation isolation) PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy See Disease Characteristics Endocrine therapy Not specified Radiotherapy No radiotherapy to maximum tolerated levels to any normal organ Surgery Not specified
Sites / Locations
- Fred Hutchinson Cancer Research Center