Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women
Breast Cancer

About this trial
This is an interventional prevention trial for Breast Cancer focused on measuring breast cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Postmenopausal women at increased risk for developing invasive breast cancer, who meet one of the following criteria: At least 12 months since spontaneous menstrual bleeding Prior documented hysterectomy and bilateral salpingo-oophorectomy At least 55 years of age with prior hysterectomy with or without oophorectomy Age 35 to 54 with a prior hysterectomy without oophorectomy OR with a status of ovaries unknown with documented follicle-stimulating hormone level demonstrating elevation in postmenopausal range Histologically confirmed lobular carcinoma in situ treated by local excision only OR a minimum projected 5 year probability of invasive breast cancer of at least 1.66%, using Breast Cancer Risk Assessment Profile No clinical evidence of malignancy on physical exam within the past 180 days No evidence of suspicious or malignant disease on bilateral mammogram within the past year No bilateral or unilateral prophylactic mastectomy No prior invasive breast cancer or intraductal carcinoma in situ Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: 35 and over Sex: Female Menopausal status: See Disease Characteristics Performance status: No restricted normal activity for a significant portion of each day Life expectancy: At least 10 years Hematopoietic: Granulocyte count at least 1,500/mm^3 Complete blood count and differential normal Platelet count normal Hepatic: SGOT or SGPT normal Bilirubin normal Alkaline phosphatase normal Renal: Creatinine normal Cardiovascular: No cerebral vascular accident, transient ischemic attack, atrial fibrillation, or uncontrolled hypertension No deep vein thrombosis Pulmonary: No pulmonary embolus Other: No other prior malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix No concurrent nonmalignant disease that would preclude administration of tamoxifen or raloxifene No clinical depression, psychiatric condition, or addictive disorder No uncontrolled diabetes PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: At least 3 months since prior estrogen or progesterone replacement therapy, oral contraceptives, androgens, luteinizing hormone-releasing hormone analogs, prolactin inhibitors, or antiandrogens At least 3 months since prior tamoxifen, raloxifene, or other selective estrogen-receptor modulators of less than 3 months duration Concurrent Estring allowed Radiotherapy: No prior breast radiotherapy Surgery: See Disease Characteristics Other: No prior systemic adjuvant therapy for breast cancer No other participation in a cancer prevention or osteoporosis prevention study involving pharmacologic intervention(s) NSABP-P-1 patients who received placebo are eligible No concurrent warfarin or cholestyramine Concurrent calcitonin or nonhormonal medication (e.g., cholecalciferol, fluoride, or bisphosphonates) allowed
Sites / Locations
- Comprehensive Cancer Institute
- MBCCOP - Gulf Coast
- Providence Alaska Medical Center
- CCOP - Western Regional, Arizona
- CCOP - Mayo Clinic Scottsdale Oncology Program
- Arizona Cancer Center at University of Arizona Health Sciences Center
- Breast Associates
- Surgical Associates
- Northeast Arkansas Clinic
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- Kaiser Permanente Medical Center - Anaheim/Orange County
- Kaiser Permanente Medical Center - Baldwin Park
- Kaiser Permanente Medical Center - Bellflower
- Alta Bates Comprehensive Cancer Center
- Providence Saint Joseph Medical Center - Burbank
- Mills-Peninsula Health Services
- Enloe Cancer Center at Enloe Medical Center
- Mount Diablo Medical Center
- Corona Regional Medical Center
- City of Hope Comprehensive Cancer Center
- Scripps Memorial Hospitals-Stevens Cancer Center - Encinitas
- North Bay Cancer Center
- Kaiser Permanente Medical Center - Fontana
- Crosson Cancer Center at St. Jude Medical Center
- Glendale Memorial Hospital Comprehensive Cancer Center
- Oncology/Hematology Associates
- Marin General Hospital Cancer Institute
- Kaiser Permanente Medical Center - Harbor City
- Hemet Valley Medical Center
- Rebecca and John Moores UCSD Cancer Center
- Valley Tumor Medical Group
- Loma Linda University Cancer Institute at Loma Linda University Medical Center
- Todd Cancer Institute at Long Beach Memorial Medical Center
- Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach
- Kaiser Permanente Medical Center - Los Angeles
- USC/Norris Comprehensive Cancer Center and Hospital
- Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center
- Kaiser Foundation Hospital - West Los Angeles
- St. Vincent Medical Center - Los Angeles
- Jonsson Comprehensive Cancer Center, UCLA
- Mission Cancer Center at Mission Hospital
- Sutter Gould Medical Foundation
- Leavey Cancer Center at Northridge Hospital Medical Center
- Breast Health Center
- St. Joseph Hospital Regional Cancer Center - Orange
- Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
- Ventura Hematology - Oncology Specialists - Oxnard
- Comprehensive Cancer Centers of the Desert
- Palo Alto Medical Foundation
- Kaiser Permanente Medical Group
- Huntington Cancer Center at Huntington Hospital
- Wilshire Oncology Medical Group, Incorporated - Pomona
- North Valley Breast Clinic
- Kaiser Permanente Medical Center - Riverside
- Sutter Roseville Medical Center
- Sutter Breast Cancer Group
- Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
- Naval Medical Center - San Diego
- California Pacific Medical Center - California Campus
- UCSF Comprehensive Cancer Center
- Cancer Center of Santa Barbara
- CCOP - Santa Rosa Memorial Hospital
- Stanford Cancer Center at Stanford University Medical Center
- Torrance Memorial Medical Center
- Santa Clarita Valley Cancer Center - UCLA
- Kaiser Permanente Medical Center - Vallejo
- Kaiser Permanente Medical Cener - Woodland Hills
- Penrose Cancer Center
- CCOP - Colorado Cancer Research Program, Incorporated
- Poudre Valley Hospital
- St. Mary-Corwin Regional Medical Center
- University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center
- Hartford Hospital
- St. Francis Hospital and Medical Center
- Manchester Memorial Hospital
- Midstate Medical Center
- New Britain General Hospital
- Hospital of St. Raphael
- Yale Comprehensive Cancer Center
- Lawrence and Memorial Hospital
- Eastern Connecticut Hematology and Oncology Associates
- Hematology Oncology, P.C.
- Northwestern Connecticut Oncology-Hematology Associates
- Windham Community Memorial Hospital
- Beebe Medical Center
- Nanticoke Memorial Hospital
- CCOP - Christiana Care Health Services
- Lombardi Cancer Center at Georgetown University Medical Center
- Washington Hospital Center
- Providence Hospital
- JFK Medical Center
- St. Vincent's Medical Center
- Baptist Regional Cancer Institute - Jacksonville
- Mayo Clinic - Jacksonville
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center
- Watson Clinic
- Lakeland Regional Cancer Center at Lakeland Regional Medical Center
- CCOP - Mount Sinai Medical Center
- University of Miami Sylvester Cancer Center
- Florida Hospital Medical Center
- MD Anderson Cancer Center Orlando
- West Florida Regional Medical Center
- Cancer Research Network Inc.
- Clinical Research Center of South Florida
- H. Lee Moffitt Cancer Center and Research Institute
- Palm Beach Cancer Institute
- CCOP - Atlanta Regional
- Medical College of Georgia
- Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
- Cancer Care and Research Pavilion at St. Joseph's/Candler
- MBCCOP - Hawaii
- North Idaho Cancer Center
- Northwest Community Hospital
- Rush Copley Medical Center
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- Northwestern Memorial Hospital
- MBCCOP - University of Illinois at Chicago
- John H. Stroger, Jr. Hospital of Cook County
- Rush Cancer Institute at Rush University Medical Center
- Resurrection Medical Center
- Our Lady of the Resurrection Medical Center
- University of Chicago Cancer Research Center
- Creticos Cancer Center at Advocate Illinois Masonic Medical Center
- CCOP - Central Illinois
- Sherman Hospital
- CCOP - Evanston
- St. Francis Hospital
- Ingalls Memorial Hospital
- Advocate South Suburban Hospital
- Evanston Northwestern Health Care - Highland Park Hospital
- Hinsdale Hematology Oncology Associates
- Joliet Oncology Hematology Associates, Limited - Joliet
- Cardinal Bernardin Cancer Center at Loyola University Medical Center
- Edward Hospital Cancer Center
- Mid-Illinois Hematology-Oncology Associates
- Advocate Christ Medical Center
- Saint James Hospital and Health Centers Comprehensive Cancer Institute
- Lutheran General Cancer Care Center
- CCOP - Illinois Oncology Research Association
- Trinity Medical Center - West
- Rockford Clinic
- Swedish-American Regional Cancer Center
- Saint Anthony Medical Center
- Edward H. Kaplan MD and Associates
- St. John's Hospital
- Memorial Medical Center
- CCOP - Carle Cancer Center
- Center for Cancer Care at Goshen Health System
- Indiana Community Cancer Care, Incorporated
- Methodist Cancer Center at Methodist Hospital
- Indiana Regional Cancer Center
- St. Vincent Hospital and Health Care Center
- Oncology Institute of Greater Lafayette
- Saint Anthony Memorial Health Centers
- Ball Memorial Hospital Cancer Center
- Community Hospital
- CCOP - Northern Indiana CR Consortium
- McFarland Clinic, P.C.
- CCOP - Cedar Rapids Oncology Project
- Medical Associates
- Jennie Edmundson Memorial Hospital
- Genesis Regional Cancer Center at Genesis Medical Center
- CCOP - Iowa Oncology Research Association
- Wendt Regional Cancer Center of Finley Hospital
- Holden Comprehensive Cancer Center at University of Iowa
- Mercy Cancer Center at Mercy Medical Center - North Iowa
- Ottumwa Regional Health Center
- Siouxland Hematology-Oncology
- Cedar Valley Medical Specialists, P.C.
- Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
- CCOP - Wichita
- King's Daughters Medical Center
- St. Elizabeth Medical Center
- HCA Kings Daughters Memorial Hospital
- Central Baptist Hospital
- Markey Cancer Center at University of Kentucky Chandler Medical Center
- Norton Healthcare Cancer Center
- James Graham Brown Cancer Center at University of Louisville
- Baptist Hospital East - Louisville
- Ochsner Clinic of Baton Rouge
- Baton Rouge General Medical Center
- Cancer Care Specialists
- MBCCOP - LSU Health Sciences Center
- Tulane Cancer Center at Tulane University Hospital and Clinic
- CCOP - Ochsner
- Cancer Treatment Center at Christus Schumpert St. Mary Place
- Eastern Maine Medical Center
- Goodall Hospital
- Maine Center for Cancer Medicine and Blood Disorders - Scarborough
- Anne Arundel Medical Center
- Greenebaum Cancer Center at University of Maryland Medical Center
- Greater Baltimore Medical Center and Cancer Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Franklin Square Hospital Center
- Suburban Hospital
- Frederick Memorial Hospital Regional Cancer Therapy Center
- Massachusetts General Hospital Cancer Center
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
- Cancer Research Center at Boston Medical Center
- Beth Israel Deaconess Medical Center
- Harvard Vanguard Medical Associates - Kenmore
- Lahey Clinic Medical Center - Burlington
- Saint Anne's Hospital
- Caritas Norwood Hospital
- NSMC Cancer Center
- Berkshire Physicians and Surgeons, P.C.
- Jordan Hospital Club Cancer Center
- Baystate Regional Cancer Program at Baystate Medical Center
- University of Massachusetts Memorial Medical Center - University Campus
- Hickman Cancer Center at Bixby Medical Center
- CCOP - Michigan Cancer Research Consortium
- University of Michigan Comprehensive Cancer Center
- Battle Creek Health System
- Bay Diagnostic Center for Women
- Community Health Center of Branch County
- Oakwood Hospital and Medical Center
- Barbara Ann Karmanos Cancer Institute
- Josephine Ford Cancer Center at Henry Ford Hospital
- St. John Hospital and Medical Center
- Hurley Medical Center
- Flint Hematology Oncology
- Genesys Regional Medical Center
- CCOP - Grand Rapids
- Holland Community Hospital
- Center for Hematology/Oncology
- CCOP - Kalamazoo
- Michigan State University Department of Surgery
- Lapeer Regional Hospital
- Marquette General Hospital
- Mercy Memorial Hospital, Corporation
- Community Cancer Care Specialist
- Memorial Healthcare
- Blue Water Oncology PC, Port Huron
- CCOP - Beaumont
- Saint Mary's Seton Cancer Institute
- Providence Cancer Institute at Providence Hospital
- Munson Medical Center
- St. John Macomb Hospital
- CCOP - Duluth
- St. Luke's Medical Clinic
- Minnesota Cooperative Group Program
- Hennepin County Medical Center - Minneapolis
- University of Minnesota
- Mayo Clinic Cancer Center
- CCOP - Metro-Minnesota
- Rice Memorial Hospital
- Coast Oncology/Hematology, P.L.L.C.
- Mid Delta Family Practice
- Hattiesburg Clinic, P.A.
- Jackson Oncology Associates, PLLC
- Keesler Medical Center - Keesler Air Force Base
- North Mississippi Hematology and Oncology Associates, Limited
- Saint Luke's Hospital
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- Freeman Cancer Institute at Freeman Health System
- St. John's Regional Medical Center
- CCOP - Kansas City
- Phelps County Regional Medical Center
- Midwest Hematology Oncology Group, Inc.
- Siteman Cancer Center
- Missouri Baptist Cancer Center
- CCOP - St. Louis-Cape Girardeau
- St. John's Regional Health Center
- CCOP - Cancer Research for the Ozarks
- Missouri Cancer Care, P.C. - St. Charles
- Ozarks Medical Center
- CCOP - Montana Cancer Consortium
- Montana Cancer Institute - Benefis Healthcare
- Kalispell Regional Medical Center
- Saint Francis Medical Center
- Cancer Center at the Good Samaritan Health Systems
- Cancer Resource Center - Lincoln
- Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
- Alegent Health - Immanuel Medical Center
- Bergan Mercy Medical Center
- Creighton University Medical Center
- CCOP - Southern Nevada Cancer Research Foundation
- New Hampshire Oncology-Hematology, PA - Hooksett
- Southern New Hampshire Medical Center
- Cooper Cancer Institute
- Englewood Hospital and Medical Center
- Hunterdon Regional Cancer Center
- CCOP - Northern New Jersey
- St. Barnabas Medical Center
- Monmouth Medical Center
- South Jersey Regional Cancer Center
- Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital
- Cancer Institute of New Jersey
- Newark Beth Israel Medical Center
- Warren Hospital
- Atlantic City Medical Center
- Booker Cancer Center at Riverview Medical Center
- Valley Hospital
- Somerset Medical Center
- Community Medical Center
- Capital Health System at Mercer
- Underwood Memorial Hospital
- Hematology-Oncology Associates, PC
- Lovelace Medical Center at Lovelace Sandia Health System
- New Mexico Oncology-Hematology Consultants, Limited
- University of New Mexico Cancer Research and Treatment Center
- New Mexico Cancer Care Associates
- New York Oncology Hematology, P.C. - Albany Regional Cancer Center
- Albert Einstein Clinical Cancer Center
- Comprehensive Cancer Center at Our Lady of Mercy Medical Center
- Roswell Park Cancer Institute
- Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
- Charles R. Wood Foundation Cancer Center at Glens Falls Hospital
- Queens Cancer Center of Queens Hospital
- New York Oncology Hematology, P.C. - Latham
- CCOP - North Shore University Hospital
- Saint Vincent Catholic Medical Center of New York
- NYU School of Medicine's Kaplan Comprehensive Cancer Center
- Memorial Sloan-Kettering Cancer Center
- Herbert Irving Comprehensive Cancer Center at Columbia University
- St. Francis Hospital and Health Centers
- Vassar Brothers Medical Center
- Genesee Surgical Associates
- Gynecologic Oncology Associates
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- University Hospital - Stony Brook
- University Hospital at State University of New York - Upstate Medical University
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
- Mission Hospitals
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
- Blumenthal Cancer Center at Carolinas Medical Center
- Presbyterian Healthcare
- Duke Comprehensive Cancer Center
- Cape Fear Valley Health System
- Gaston Hematology and Oncology
- Southeastern Medical Oncology Center
- Moses Cone Regional Cancer Center at Wesley Long Community Hospital
- Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina
- Pardee Memorial Hospital
- Cornerstone Surgery
- Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer Center
- Cancer Center at Iredell Memorial Hospital
- New Hanover Regional Medical Center
- Forsyth Medical Center
- CCOP - Southeast Cancer Control Consortium
- Comprehensive Cancer Center at Wake Forest University
- Quain & Ramstad Clinic
- CCOP - Merit Care Hospital
- Akron General Medical Center
- Mercy Medical Center
- Aultman Hospital Cancer Center at Aultman Health Foundation
- Cancer Center at Christ Hospital
- Bethesda North Hospital
- Charles M. Barrett Cancer Center at University Hospital
- Ireland Cancer Center
- Fairview Hospital
- Kaiser Permanente
- Cleveland Clinic Taussig Cancer Center
- CCOP - Columbus
- Arthur G. James Cancer Hospital - Ohio State University
- Blanchard Valley Medical Associates
- Fremont Memorial Hospital
- Cleveland Clinic Cancer Center
- CCOP - Dayton
- Lima Memorial Hospital
- St. Luke's Hospital
- Parma Community General Hospital
- Firelands Regional Medical Center
- Flower Hospital - ProMedica Health System
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical College of Ohio Cancer Institute
- St. Charles Hospital
- CCOP - Toledo Community Hospital
- Toledo Clinic, Incorporated
- Cleveland Clinic Health System STAR BCPT
- Fulton County Health Center
- Muskogee Regional Medical Center
- Frank C. Love Cancer Institute at St. Anthony Hospital
- Central Oklahoma Cancer Center at INTEGRIS Southwest Medical Center
- Mercy Health Center
- Oklahoma University Medical Center at University of Oklahoma Health Sciences Center
- St. John Health System
- CCOP - Oklahoma
- St. Charles Medical Center
- Cancer Institute at Oregon Health and Science University
- CCOP - Columbia River Oncology Program
- Kaiser Permanente Center for Health Research
- Abington Memorial Hospital
- Sacred Heart Hospital
- John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
- Bon Secours-Holy Family Health System
- St. Luke's Hospital Cancer Center
- Bryn Mawr Hospital
- Geisinger Medical Center
- Mercy Fitzgerald Hospital
- Doylestown Hospital
- Delaware County Memorial Hospital
- Easton Hospital
- Ephrata Community Hopital
- Regional Cancer Center - Erie
- Pinnacle Health Regional Cancer Center at Pinnacle Health System
- Mercy Community Hospital
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Lancaster General Hospital
- Saint Mary Regional Cancer Center
- Riddle Memorial Hospital
- Cancer Center at Paoli Memorial Hospital
- Abramson Cancer Center at University of Pennsylvania Medical Center
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Pennsylvania Oncology Hematology Associates
- Fox Chase Cancer Center
- Frankford Hospital
- Chestnut Hill Healthcare
- Fox Chase - Temple Cancer Center
- Albert Einstein Cancer Center
- Mercy Hospital of Philadelphia
- Allegheny General Hospital
- Hillman Cancer Center at University of Pittsburgh Cancer Institute
- Pottstown Memorial Regional Cancer Center
- Reading Hospital and Medical Center
- Grand View Hospital
- Crozer-Chester Medical Center
- Chester County Hospital
- Lankenau Cancer Center at Lankenau Hospital
- Wellspan Health - York Cancer Center
- Rhode Island Hospital
- AnMed Health
- Roper St. Francis Healthcare - Roper Hospital
- Hollings Cancer Center at Medical University of South Carolina
- Palmetto Richland Memorial Hospital
- McLeod Regional Medical Center
- Cancer Centers of the Carolinas - Eastside
- CCOP - Upstate Carolina
- Rapid City Regional Hospital
- CCOP - Sioux Community Cancer Consortium
- Wellmont Holston Valley Hospital and Medical Center
- Thompson Cancer Survival Center
- U.T. Cancer Institute at University of Tennessee Medical Center
- Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - Memphis
- MBCCOP - Meharry Medical College - Nashville
- Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center
- Hendrick Cancer Center
- Harrington Cancer Center
- Julie and Ben Rogers Cancer Center
- Presbyterian Hospital of Dallas
- Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
- Charles A. Sammons Cancer Center
- Methodist Dallas Medical Center
- Providence Memorial Hospital
- Harris Methodist Fort Worth
- University of Texas - MD Anderson Cancer Center
- Baylor College of Medicine
- Texas Cancer Institute at St. Luke's Episcopal Hospital
- Baylor Medical Center at Garland
- Wilford Hall Medical Center
- Sanchez Cancer Center
- Joe Arrington Cancer Research and Treatment Center
- Southwest Cancer and Research Center at University Medical Center
- Memorial Health System of East Texas
- Baylor/Richardson Cancer Center
- University of Texas Health Science Center at San Antonio
- CCOP - Scott and White Hospital
- University of Texas Health Center at Tyler
- Huntsman Cancer Institute
- Green Mountain Oncology Group
- Southwestern Vermont Regional Cancer Center
- Mountainview Medical
- Vermont Cancer Center at University of Vermont
- Community Cancer Center at Rutland Regional Medical Center
- Martha Jefferson Hospital
- Cancer Center of the Piedmont, Inc.
- Danville Hematology and Oncology, Incorporated
- Virginia Oncology Associates - Newport News
- Henrico Doctors' Hospital - Parham Campus
- MBCCOP - Massey Cancer Center
- Oncology and Hematology Associates of Southwest Virginia, Inc.
- St. Joseph Hospital Community Cancer Center
- Olympic Hematology and Oncology
- Flynn Cancer Center at Providence Everett Medical Center - Pacific Campus
- CCOP - Virginia Mason Research Center
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- Fred Hutchinson Cancer Research Center
- Cancer Care Northwest - Spokane North
- Rockwood Clinic P.S.
- CCOP - Northwest
- Yakima Regional Cancer Care Center
- David Lee Cancer Center at Charleston Area Medical Center
- Camden-Clark Memorial Hospital
- Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
- University of Wisconsin Comprehensive Cancer Center
- CCOP - Marshfield Clinic Research Foundation
- Aurora Sinai Medical Center
- Oncology Alliance, S.C.
- Medical College of Wisconsin Cancer Center
- Waukesha Memorial Hospital Regional Cancer Center
- UW Cancer Center Wausau Hospital
- Tom Baker Cancer Center - Calgary
- Cross Cancer Institute
- University Hospital - U.B.C. Site
- CancerCare Manitoba
- Familial Oncology Program
- Credit Valley Hospital
- North York General Hospital, Ontario
- Ottawa Regional Cancer Centre
- Northwestern Ontario Regional Cancer Care
- Toronto Sunnybrook Regional Cancer Centre
- St. Michael's Hospital - Toronto
- Toronto General Hospital
- Women's College Ambulatory Care Center, Sunnybrook and Women's College Health Science Center
- CHUS-Hopital Fleurimont
- Hopital Charles Lemoyne
- Centre Hospitalier de l'Universite de Montreal
- Royal Victoria Hospital - Montreal
- Montreal General Hospital
- Ville Marie Breast Center
- Jewish General Hospital - Montreal
- Hopital du Saint-Sacrement, Quebec
- Centre Universitaire de Sante de L'Estrie
- Saskatoon Cancer Centre
- MBCCOP - San Juan
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Group 1
Group 2
Tamoxifen and placebo
Raloxifene and Placebo