Genetic Testing Plus Irinotecan in Treating Patients With Solid Tumors or Lymphoma
AIDS-related Peripheral/Systemic Lymphoma, AIDS-related Primary CNS Lymphoma, Anaplastic Large Cell Lymphoma
About this trial
This is an interventional treatment trial for AIDS-related Peripheral/Systemic Lymphoma
Eligibility Criteria
Inclusion Criteria: Histologically proven solid tumor or lymphoma Responded to irinotecan OR no existing curative therapy No leukemia Measurable or evaluable disease Performance status - Karnofsky 70-100% WBC at least 3500/mm^3 Absolute neutrophil count at least 1500/mm^3 Platelet count at least 100,000/mm^3 Bilirubin normal SGOT/SGPT less than 5 times upper limit of normal (unless due to disease) Creatinine no greater than 1.5 mg/dL Creatinine clearance at least 60 mL/min Not pregnant or nursing Fertile patients must use effective contraception No inflammatory bowel disease requiring therapy No chronic diarrhea syndrome or paralytic ileus At least 2 weeks since prior colony stimulating factor At least 4 weeks since prior biologic therapy No concurrent biologic therapy See Disease Characteristics At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) No other concurrent chemotherapy At least 4 weeks since prior radiotherapy to greater than 25% of bone marrow No concurrent palliative radiotherapy No prior transplant No concurrent substrates of UGT1A1 enzyme No concurrent inducers or inhibitors of UGT1A1 enzyme activity
Sites / Locations
- University of Chicago Comprehensive Cancer Center
Arms of the Study
Arm 1
Experimental
Treatment (irinotecan hydrochloride)
Patients receive irinotecan IV over 90 minutes once every 3 weeks. Treatment continues for at least 2 courses in the absence of disease progression or unacceptable toxicity.