Bryostatin 1 and Interleukin-2 in Treating Patients With Refractory Solid Tumors or Lymphoma
Lymphoma, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage IV adult Hodgkin lymphoma, recurrent adult Hodgkin lymphoma, stage IV cutaneous T-cell non-Hodgkin lymphoma, recurrent cutaneous T-cell non-Hodgkin lymphoma, small intestine lymphoma, unspecified adult solid tumor, protocol specific, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, stage IV adult diffuse small cleaved cell lymphoma, stage IV adult diffuse mixed cell lymphoma, stage IV adult diffuse large cell lymphoma, stage IV adult immunoblastic large cell lymphoma, stage IV adult lymphoblastic lymphoma, stage IV adult Burkitt lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent adult diffuse small cleaved cell lymphoma, recurrent adult diffuse mixed cell lymphoma, recurrent adult diffuse large cell lymphoma, recurrent adult immunoblastic large cell lymphoma, recurrent adult lymphoblastic lymphoma, recurrent adult Burkitt lymphoma, stage IV adult T-cell leukemia/lymphoma, recurrent adult T-cell leukemia/lymphoma, primary central nervous system non-Hodgkin lymphoma, intraocular lymphoma, stage IV mantle cell lymphoma, recurrent mantle cell lymphoma, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, stage IV mycosis fungoides/Sezary syndrome, recurrent mycosis fungoides/Sezary syndrome, recurrent marginal zone lymphoma, recurrent small lymphocytic lymphoma, stage IV small lymphocytic lymphoma, stage IV marginal zone lymphoma, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, nodal marginal zone B-cell lymphoma, splenic marginal zone lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven solid tumor or lymphoma that is not curable by surgery, radiotherapy, or standard chemotherapy, or for which no curative therapy exists Prostate cancer patients must have the following: Tumor progression following blockade of both testicular and adrenal androgens Serum testosterone in the castrate range (less than 20 ng/mL) At least 3 months since prior suramin therapy At least 4 weeks since prior flutamide or other antiandrogen medication and no evidence of response to treatment Luprolide should continue if no prior orchiectomy No prior or concurrent brain metastases PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0 or 1 Life expectancy: At least 3 months Hematopoietic: WBC at least 3,500/mm^3 OR Granulocyte count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hemoglobin at least 8 g/dL Hepatic: Hepatitis B surface antigen negative PT no greater than 14 seconds PTT no greater than 35 seconds Bilirubin no greater than 1.5 mg/dL unless due to Gilbert's disease SGOT and SGPT no greater than 2.5 times upper limit of normal (ULN) Alkaline phosphatase no greater than 2.5 times ULN Albumin at least 2.5 g/dL Renal: Creatinine no greater than 1.5 mg/dL OR Creatinine clearance at least 50 mL/min Corrected calcium at least 8.0 mg/dL, but no greater than 10.7 mg/dL Cardiovascular: No prior myocardial infarction, coronary artery disease (CAD), congestive heart failure, second or third degree AV block, or cardiac arrhythmias requiring treatment No evidence of CAD on EKG Pulmonary: FEV1-1 at least 70% predicted DLCO at least 60% predicted Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception HIV negative At least 1 week since active infection requiring antibiotics No other medical or psychiatric condition that would preclude study No prior or concurrent seizure disorders controlled with medication PRIOR CONCURRENT THERAPY: Biologic therapy: At least 4 weeks since prior interleukin-2 At least 4 weeks since other prior biologic therapy for solid tumors or lymphomas Chemotherapy: See Disease Characteristics At least 4 weeks since prior bryostatin 1 At least 4 weeks since other prior chemotherapy for solid tumors or lymphomas Endocrine therapy: See Disease Characteristics At least 4 weeks since other prior endocrine therapy for solid tumors or lymphomas No absolute requirement for corticosteroids Radiotherapy: See Disease Characteristics At least 4 weeks since prior radiotherapy for solid tumors or lymphomas Surgery: See Disease Characteristics At least 4 weeks since prior surgery for solid tumors or lymphomas Other: No absolute requirement for nonsteroidal anti-inflammatory drugs or H2 blockers
Sites / Locations
- National Institute on Aging - Baltimore