S9900: Surgery With or Without Combination Chemotherapy in Treating Patients With Non-small Cell Lung Cancer
Lung Cancer

About this trial
This is an interventional treatment trial for Lung Cancer focused on measuring stage I non-small cell lung cancer, stage II non-small cell lung cancer, stage IIIA non-small cell lung cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically proven non-small cell lung cancer (NSCLC), meeting 1 of the following staging criteria: Stage IB (T2, N0) Stage II T1-2, N1 with negative mediastinoscopy OR T3, N0 Selected stage IIIA with negative mediastinoscopies T3, N1, excluding superior sulcus Positive level 10 hilar nodes allowed if mediastinoscopy negative Apical tumors with no clinical symptoms allowed No symptomatic tumors (T3, N0 or T3, N1) involving the superior sulcus No Pancoast's tumors Negative mediastinoscopy required in all patients with clinically positive mediastinal or hilar lymph nodes to ensure no N2 disease Bidimensionally measurable or evaluable disease by chest x-ray or contrast-enhanced CT scan T3, N0 disease assessable only by bronchoscopy must be affirmed by 2 observers and documented by photograph that includes main carina PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Zubrod 0 or 1 Life expectancy: Not specified Hematopoietic: Granulocyte count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 WBC at least 4,000/mm^3 Hepatic: Bilirubin no greater than 1.5 times upper limit of normal (ULN) SGOT or SGPT no greater than 2 times ULN Alkaline phosphatase no greater than 2 times ULN Renal: Creatinine no greater than 1.5 times ULN Creatinine clearance at least 50 mL/min Pulmonary: See Disease Characteristics Preresection FEV_1 greater than 2.0 L OR Predicted postresection FEV_1 greater than 1.0 L No postobstructive pneumonia Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No serious infection No other serious medical condition that would preclude study compliance No prior allergic reactions to drugs containing Cremophor No prior malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior systemic chemotherapy for NSCLC No other concurrent chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior systemic radiotherapy for NSCLC No concurrent radiotherapy Surgery: At least 5 years since prior resection of lung disease Other: No other concurrent investigational therapy No other concurrent anticancer therapy
Sites / Locations
- University of Alabama at Birmingham Comprehensive Cancer Center
- Comprehensive Cancer Institute
- Huntsville Hospital
- MBCCOP - Gulf Coast
- Montgomery Cancer Center
- DCH Cancer Treatment Center
- Radiation Oncology Associates of West Alabama
- Foundation for Cancer Research and Education
- CCOP - Mayo Clinic Scottsdale Oncology Program
- Providence Saint Joseph Medical Center - Burbank
- Mount Diablo Medical Center
- California Cancer Center
- Saint Agnes Cancer Center
- Sutter Health Western Division Cancer Research Group
- Loma Linda University Cancer Institute at Loma Linda University Medical Center
- Veterans Affairs Medical Center - Long Beach
- USC/Norris Comprehensive Cancer Center and Hospital
- Jonsson Comprehensive Cancer Center, UCLA
- CCOP - Bay Area Tumor Institute
- Huntington Cancer Center at Huntington Hospital
- Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
- Radiation Oncology Centers - Sacramento
- Radiation Medical Group, Incorporated
- Naval Medical Center - San Diego
- UCSF Comprehensive Cancer Center
- O'Connor Hospital
- CCOP - Santa Rosa Memorial Hospital
- Stanford Cancer Center at Stanford University Medical Center
- Torrance Memorial Medical Center
- David Grant Medical Center
- Memorial Hospital Cancer Center
- University of Colorado Cancer Center at University of Colorado Health Sciences Center
- CCOP - Colorado Cancer Research Program, Incorporated
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
- Hospital of St. Raphael
- Yale Comprehensive Cancer Center
- CCOP - Christiana Care Health Services
- Sibley Memorial Hospital
- Halifax Medical Center
- 21st Century Oncology - Fort Myers
- Shands Cancer Center at the University of Florida Health Science Center
- Florida Radiation Oncology Group
- Mayo Clinic - Jacksonville
- Holmes Regional Medical Center
- CCOP - Mount Sinai Medical Center
- University of Miami Sylvester Cancer Center
- Baptist Hospital of Miami
- MD Anderson Cancer Center Orlando
- Bay Medical Center
- Gulf Coast Cancer Treatment Center
- Sarasota Radiation and Medical Oncology Center
- Tallahassee Memorial Hospital
- H. Lee Moffitt Cancer Center and Research Institute
- Winship Cancer Institute of Emory University
- CCOP - Atlanta Regional
- Medical Center/John B. Amos Community Cancer Center
- Veterans Affairs Medical Center - Atlanta (Decatur)
- Regional Radiation Oncology Center at Rome
- MBCCOP - Hawaii
- Northwest Community Hospital
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- CCOP - Central Illinois
- Cancer Care Center at Advocate Good Samaritan Hospital
- Ingalls Memorial Hospital
- Cardinal Bernardin Cancer Center at Loyola University Medical Center
- Lutheran General Cancer Care Center
- CCOP - Illinois Oncology Research Association
- CCOP - Scott and White Hospital
- Methodist Medical Center of Illinois
- CCOP - Carle Cancer Center
- St. John's Cancer Center at St. John's Medical Center
- Bloomington Hospital
- Indiana University Cancer Center
- Veterans Affairs Medical Center - Indianapolis (Roudebush)
- Methodist Cancer Center at Methodist Hospital
- Community Regional Cancer Care
- Ball Memorial Hospital Cancer Center
- CCOP - Northern Indiana CR Consortium
- CCOP - Cedar Rapids Oncology Project
- CCOP - Iowa Oncology Research Association
- Wendt Regional Cancer Center of Finley Hospital
- Siouxland Hematology-Oncology
- CCOP - Wichita
- St. Elizabeth Medical Center
- Central Baptist Hospital
- Markey Cancer Center at University of Kentucky Chandler Medical Center
- James Graham Brown Cancer Center at University of Louisville
- Louisville Radiation Oncology Center at Caritas Regional Cancer Center
- Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County
- Mary Bird Perkins Cancer Center
- Tulane Cancer Center at Tulane University Hospital and Clinic
- MBCCOP - LSU Health Sciences Center
- CCOP - Ochsner
- Maine Medical Center
- Anne Arundel Oncology Center
- Greenebaum Cancer Center at University of Maryland Medical Center
- Greater Baltimore Medical Center and Cancer Center
- Harbor Hospital Center
- Sinai Hospital of Baltimore
- St. Agnes Cancer Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Peninsula Regional Medical Center
- Tufts - New England Medical Center
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
- Cancer Research Center at Boston Medical Center
- Beth Israel Deaconess Medical Center
- Cape Cod Hospital
- Veterans Affairs Medical Center - Boston (Jamaica Plain)
- NSMC Cancer Center
- CCOP - Michigan Cancer Research Consortium
- University of Michigan Comprehensive Cancer Center
- Barbara Ann Karmanos Cancer Institute
- Josephine Ford Cancer Center at Henry Ford Hospital
- Hurley Medical Center
- McLaren Regional Cancer Center
- CCOP - Kalamazoo
- Marquette General Hospital
- MidMichigan Medical Center - Midland
- CCOP - Beaumont
- William Beaumont Hospital - Royal Oak
- William Beaumont Hospital - Troy
- CCOP - Duluth
- Veterans Affairs Medical Center - Minneapolis
- Fairview University Medical Center - University Campus
- Mayo Clinic Cancer Center
- Coborn Cancer Center
- CCOP - Metro-Minnesota
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- CCOP - Kansas City
- St. Louis University Hospital Cancer Center
- Cancer Research for the Ozarks
- CCOP - Cancer Research for the Ozarks
- Siteman Cancer Center
- CCOP - Montana Cancer Consortium
- CCOP - Missouri Valley Cancer Consortium
- Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
- UNMC Eppley Cancer Center at the University of Nebraska Medical Center
- CCOP - Southern Nevada Cancer Research Foundation
- Comprehensive Cancer Centers of Nevada
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
- Elliot Regional Cancer Center
- Veterans Affairs Medical Center - East Orange
- John F. Kennedy Medical Center
- Trinitas Hospital - Jersey Street Campus
- Monmouth Medical Center
- South Jersey Regional Cancer Center
- Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital
- Cancer Institute of New Jersey
- Newark Beth Israel Medical Center
- Atlantic City Medical Center
- Medical Center of Princeton
- Valley Hospital
- Community Medical Center
- Fox Chase Cancer Center at St. Francis Medical Center
- Associated Radiologists, P.A.
- Radiation Oncology Associates of Albuquerque
- Cancer Center of Albany Medical Center
- MBCCOP-Our Lady of Mercy Cancer Center
- SUNY Downstate Medical Center
- New York Methodist Hospital
- Roswell Park Cancer Institute
- Finger Lakes Radiation Oncology Center
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
- CCOP - North Shore University Hospital
- Beth Israel Medical Center - Philipps Ambulatory Care Center
- Memorial Sloan-Kettering Cancer Center
- Herbert Irving Comprehensive Cancer Center at Columbia University
- Champlain Valley Physicians Hospital Medical Center
- Vassar Brothers Medical Center
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- Riverhill Radiation Oncology
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
- Batte Cancer Center at Northeast Medical Center
- Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina
- CCOP - Southeast Cancer Control Consortium
- Comprehensive Cancer Center at Wake Forest University
- Medcenter One Health System
- CCOP - Merit Care Hospital
- Altru Cancer Center
- Trinity Cancer Care Center
- Akron General Medical Center
- Akron City Hospital
- Cancer Center at Christ Hospital
- Charles M. Barrett Cancer Center at University Hospital
- MetroHealth's Cancer Care Center at MetroHealth Medical Center
- University Hospitals of Cleveland
- Cleveland Clinic Taussig Cancer Center
- CCOP - Columbus
- Arthur G. James Cancer Hospital - Ohio State University
- CCOP - Dayton
- Parma Community General Hospital
- CCOP - Toledo Community Hospital
- Frank C. Love Cancer Institute at St. Anthony Hospital
- Oklahoma University Medical Center
- St. John Health System
- CCOP - Oklahoma
- CCOP - Columbia River Oncology Program
- Abington Memorial Hospital
- John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
- St. Luke's Hospital Cancer Center
- CCOP - Geisinger Clinic and Medical Center
- Geisinger Medical Center
- Mercy Fitzgerald Hospital
- Delaware County Memorial Hospital
- Dale and Frances Hughes Cancer Center
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Abramson Cancer Center at University of Pennsylvania Medical Center
- Veterans Affairs Medical Center - Philadelphia
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Fox Chase Cancer Center
- Albert Einstein Cancer Center
- Allegheny General Hospital
- Mercy Hospital of Pittsburgh
- Western Pennsylvania Hospital
- Hillman Cancer Center at University of Pittsburgh Cancer Institute
- Reading Hospital and Medical Center
- Mercy Hospital Cancer Center - Scranton
- Wilkes-Barre General Hospital
- CCOP - MainLine Health
- Wellspan Health - York Cancer Center
- Roger Williams Medical Center
- CCOP - Greenville
- CCOP - Upstate Carolina
- Rapid City Regional Hospital
- CCOP - Sioux Community Cancer Consortium
- West Tennessee Cancer Center at Jackson-Madison County General Hospital
- Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center
- Harrington Cancer Center
- Arlington Cancer Center
- University of Texas Medical Branch
- University of Texas - MD Anderson Cancer Center
- Wilford Hall Medical Center
- Joe Arrington Cancer Research and Treatment Center
- Bayshore Medical Center
- University of Texas Health Science Center at San Antonio
- Cottonwood Hospital Medical Center
- Utah Valley Regional Medical Center - Provo
- Dixie Regional Medical Center
- University of Utah Health Sciences Center
- LDS Hospital
- Green Mountain Oncology Group
- Vermont Cancer Center at University of Vermont
- Cancer Center at the University of Virginia
- RMH Regional Cancer Center
- Naval Medical Center, Portsmouth
- Bon Secours - St. Mary's Hospital
- Massey Cancer Center at Virginia Commonwealth University
- Cancer Institute at Virginia Mason Medical Center
- University Cancer Center at University of Washington Medical Center
- Deaconess Medical Center
- Yakima Valley Memorial Hospital
- Schiffler Cancer Center at Wheeling Hospital
- CCOP - St. Vincent Hospital Cancer Center, Green Bay
- St. Vincent Hospital
- Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
- Veterans Affairs Medical Center - Madison
- Southern Wisconsin Radiotherapy Center
- University of Wisconsin Comprehensive Cancer Center
- CCOP - Marshfield Clinic Research Foundation
- Marshfield Clinic
- Community Memorial Hospital
- Columbia Hospital
- St. Luke's Medical Center
- Medical College of Wisconsin Cancer Center
- Veterans Affairs Medical Center - Milwaukee (Zablocki)
- All Saints Cancer Center at All Saints Healthcare
- Waukesha Memorial Hospital Regional Cancer Center
- Tom Baker Cancer Center - Calgary
- Cross Cancer Institute
- Doctor Leon Richard Oncology Centre
- Saint John Regional Hospital
- Newfoundland Cancer Treatment and Research Foundation
- Nova Scotia Cancer Centre
- Margaret and Charles Juravinski Cancer Centre
- Kingston Regional Cancer Centre
- Cancer Care Ontario-London Regional Cancer Centre
- Ottawa Regional Cancer Centre
- Northeastern Ontario Regional Cancer Centre at Regional Hospital of Sudbury Regional Hospital
- Northwestern Ontario Regional Cancer Care
- Toronto Sunnybrook Regional Cancer Centre
- Princess Margaret Hospital
- CHUS-Hopital Fleurimont
- Centre Hospitalier de l'Universite de Montreal
- McGill University
- Centre Hospitalier Universitaire de Quebec
- Allan Blair Cancer Centre
- Saskatoon Cancer Centre
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
preooperative chemo followed by surgery
Surgery alone
carboplatin paclitaxel conventional surgery
conventional surgery