Gene Therapy in Treating Patients With Cancer
Cancer

About this trial
This is an interventional treatment trial for Cancer focused on measuring stage III colon cancer, stage IV colon cancer, stage III gastric cancer, stage IV gastric cancer, recurrent gastric cancer, recurrent non-small cell lung cancer, stage II pancreatic cancer, stage III pancreatic cancer, recurrent pancreatic cancer, stage III rectal cancer, stage IV rectal cancer, recurrent colon cancer, recurrent rectal cancer, stage II esophageal cancer, stage III esophageal cancer, stage IV esophageal cancer, recurrent esophageal cancer, stage III cervical cancer, recurrent cervical cancer, stage IVB cervical cancer, stage IVA cervical cancer, adenocarcinoma of the prostate, stage III renal cell cancer, stage IV renal cell cancer, recurrent renal cell cancer, stage III ovarian epithelial cancer, stage IV ovarian epithelial cancer, recurrent ovarian epithelial cancer, adenocarcinoma of the stomach, extensive stage small cell lung cancer, recurrent small cell lung cancer, stage III vaginal cancer, stage IVA vaginal cancer, stage IVB vaginal cancer, recurrent vaginal cancer, localized unresectable adult primary liver cancer, advanced adult primary liver cancer, recurrent adult primary liver cancer, stage III endometrial carcinoma, stage IV endometrial carcinoma, recurrent endometrial carcinoma, small intestine adenocarcinoma, unresectable gallbladder cancer, recurrent gallbladder cancer, unresectable extrahepatic bile duct cancer, recurrent extrahepatic bile duct cancer, recurrent small intestine cancer, stage III bladder cancer, recurrent bladder cancer, stage IV bladder cancer, stage III prostate cancer, stage IV prostate cancer, recurrent prostate cancer, stage IV non-small cell lung cancer, stage III salivary gland cancer, stage IV salivary gland cancer, recurrent salivary gland cancer, duct cell adenocarcinoma of the pancreas, ovarian undifferentiated adenocarcinoma, adenocarcinoma of the lung, adenocarcinoma of the esophagus, intestinal adenocarcinoma of the stomach, adenocarcinoma of the colon, diffuse adenocarcinoma of the stomach, mixed adenocarcinoma of the stomach, mucinous adenocarcinoma of the colon, signet ring adenocarcinoma of the colon, adenocarcinoma of the rectum, adenocarcinoma of the gallbladder, mucinous adenocarcinoma of the rectum, signet ring adenocarcinoma of the rectum, adenocarcinoma with squamous metaplasia of the gallbladder, adenocarcinoma of the extrahepatic bile duct, ovarian serous cystadenocarcinoma, ovarian mucinous cystadenocarcinoma, ovarian endometrioid adenocarcinoma, ovarian clear cell cystadenocarcinoma, vaginal adenocarcinoma, vaginal clear cell adenocarcinoma, endometrial adenocarcinoma, cervical adenocarcinoma, adenocarcinoma of the bladder, salivary gland adenocarcinoma, adenocarcinoma of unknown primary, adenocarcinoma of the pancreas, stage IV pancreatic cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven CEA expressing adenocarcinoma Serum CEA levels greater than 10 ng/mL Failed standard therapy Measurable disease PATIENT CHARACTERISTICS: Age: 18 and over Performance status: 0-2 Life expectancy: Greater than 2 months Hematopoietic: Not specified Hepatic: No significant hepatic disease Bilirubin no greater than 3 mg/dL No active clinical disease caused by hepatitis B Renal: No significant renal disease Creatinine no greater than 3 mg/dL Cardiovascular: No significant cardiovascular disease Pulmonary: No significant pulmonary disease Other: Not pregnant Negative pregnancy test Fertile patients must use effective contraception No significant endocrine, rheumatologic, or allergic disease No active clinical disease caused by cytomegalovirus or tuberculosis HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: At least 4 weeks since prior chemotherapy Endocrine therapy: Not specified Radiotherapy: At least 4 weeks since prior radiotherapy Surgery: Not specified
Sites / Locations
- Beth Israel Deaconess Medical Center