Back to resultsCombination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
Primary Purpose
Lymphoma
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
rituximab
CHOP regimen
cyclophosphamide
doxorubicin hydrochloride
prednisone
vincristine sulfate
Sponsored by
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically proven stage III or IV follicular non-Hodgkin's lymphoma (NHL) Relapsed after or no response (no change/progressive disease) to no more than 2 adequate non-anthracycline-containing systemic chemotherapy regimens At least 2 months of single-agent therapy (e.g., chlorambucil) AND/OR At least 2 consecutive courses of polychemotherapy (e.g., cyclophosphamide, vincristine, and prednisone) or purine analogues Complete or partial remission or no change for at least 4 weeks after completion of prior therapy OR progression during one of a maximum of 2 prior therapy regimens CD20 positive At least 1 bidimensionally measurable mass No greater than 10,000,000/mL circulating tumor cells IgG levels at least 3 g/L No low-grade NHL transformed into intermediate- or high-grade NHL No symptomatic CNS lymphoma No bone marrow involvement only NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-2 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Bilirubin less than 2.5 times upper limit of normal (ULN) Alkaline phosphatase less than 2.5 times ULN Renal: Creatinine less than 2.5 times ULN BUN less than 2.5 times ULN Cardiovascular: No severe cardiac disease (i.e., severe heart failure requiring symptomatic treatment) Pulmonary: No severe pulmonary disease Other: No severe neurologic or psychiatric disease No severe metabolic disease Not pregnant Fertile patients must use effective contraception No prior malignancy within the past 5 years except nonmelanomatous skin cancer, carcinoma in situ of the cervix, or other cancer curatively treated with surgical therapy HIV negative No uncontrolled asthma or allergy requiring steroids No known hypersensitivity or prior anaphylactic reaction to murine proteins or any component of study drug PRIOR CONCURRENT THERAPY: Biologic therapy: No prior rituximab No prior allogeneic or autologous peripheral blood stem cell transplantation Concurrent filgrastim (G-CSF) for stem cell mobilization allowed Chemotherapy: See Disease Characteristics No prior anthracyclines or mitoxantrone No concurrent chemotherapy for stem cell mobilization Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: Not specified
Sites / Locations
- Canberra Hospital
- Concord Repatriation General Hospital
- Cancer Therapy Centre at Liverpool Hospital
- Institute of Oncology at Prince of Wales Hospital
- Prince of Wales Private Hospital
- Royal North Shore Hospital
- St. Vincent's Hospital
- Sydney Cancer Centre at Royal Prince Alfred Hospital
- St. George Hospital and Community Health Service
- Westmead Breast Centre at NSW Breast Cancer Institute
- Westmead Hospital
- Wollongong Hospital
- Wesley Medical Centre
- Royal Brisbane and Women's Hospital
- Princess Alexandra Hospital
- Greenslopes Private Hospital
- Townsville General Hospital
- Royal Adelaide Hospital Cancer Centre
- Ashford Cancer Centre
- Flinder Medical Centres
- Queen Elizabeth Hospital
- Royal Hobart Hospital
- St. John of God Hospital
- Box Hill Hospital
- John Fawkner Hospital
- Peter MacCallum Cancer Centre
- St. Vincent's Hospital
- Frankston Hospital
- Geelong Hospital
- Austin Hospital
- Alfred Hospital
- Garden Consulting Rooms
- Royal Melbourne Hospital
- Fremantle Hospital
- Mount Medical Centre
- Royal Perth Hospital
- Sir Charles Gairdner Hospital - Perth
- Ziekenhuis Netwerk Antwerpen Middelheim
- Institut Jules Bordet
- Universitair Ziekenhuis Antwerpen
- Algemeen Ziekenhuis Sint Lucas
- U.Z. Gasthuisberg
- H. Hartziekenhuis - Roeselaere.
- Algemeen Ziekenhuis Sint-Augustinus
- Tom Baker Cancer Centre - Calgary
- Cross Cancer Institute at University of Alberta
- British Columbia Cancer Agency - Centre for the Southern Interior
- Nanaimo Cancer Clinic at Nanaimo Regional General Hospital
- Lions Gate Hospital
- Fraser Valley Cancer Centre at British Columbia Cancer Agency
- British Columbia Cancer Agency - Vancouver Cancer Centre
- CancerCare Manitoba
- Moncton Hospital
- Newfoundland Cancer Treatment and Research Foundation
- Nova Scotia Cancer Centre at Queen Elizabeth II Health Sciences Centre
- Royal Victoria Hospital of Barrie
- Margaret and Charles Juravinski Cancer Centre
- Cancer Centre of Southeastern Ontario at Kingston General Hospital
- London Regional Cancer Program at London Health Sciences Centre
- Trillium Health Centre - Mississauga Site
- Ottawa Hospital Regional Cancer Centre - General Campus
- Hotel Dieu Health Sciences Hospital - Niagara
- Northeastern Ontario Regional Cancer Centre
- Northwestern Ontario Regional Cancer Care at Thunder Bay Regional Health Sciences Centre
- Toronto Sunnybrook Regional Cancer Centre at Sunnybrook and Women's College Health Sciences Centre
- Princess Margaret Hospital
- St. Joseph's Health Centre - Toronto
- Humber River Regional Hospital - Weston
- Windsor Regional Cancer Centre at Windsor Regional Hospital
- Hopital Charles Lemoyne
- Maisonneuve-Rosemont Hospital
- McGill Cancer Centre at McGill University
- Hopital Du Sacre-Coeur de Montreal
- Hopital Notre- Dame du CHUM
- Hopital du Saint-Sacrement, Quebec
- Allan Blair Cancer Centre at Pasqua Hospital
- Rigshospitalet - Copenhagen University Hospital
- Vejle Sygehus
- National Cancer Institute of Egypt
- Institut Bergonie
- Institut Gustave Roussy
- National Institute of Oncology
- Centro di Riferimento Oncologico - Aviano
- Hagaziekenhuis
- Jeroen Bosch Ziekenhuis
- Medisch Centrum Alkmaar
- Ijselmeer Ziekenhuis - Zuiderzeeziekenhuis
- Meander Medisch Centrum
- St. Lucas - Andreas Ziekenhuis
- Vrije Universiteit Medisch Centrum
- Boveny Ziekenhuis
- Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Slotervaart Ziekenhuis
- Onze Lieve Vrouwe Gasthuis
- Academisch Medisch Centrum at University of Amsterdam
- Albert Schweitzerziekenhuis- Zwijndrecht
- Scheperziekenhuis
- Gelre Ziekenhuizen - Lokatie Lukas
- Ziekenhuis Lievensberg
- Streekziekenhuis Gooi-Noord
- Amphia Ziekenhuis - locatie Langendijk
- Amphia Ziekenhuis - locatie Molengracht
- Atrium Medical Centre - Brunssum
- Ijsselland Ziekenhuis
- Reinier de Graaf Group - Delft
- Red Cross Hospital
- Gemini Ziekenhuis
- Deventer Ziekenhuisen
- Van Weel Bethesda Ziekenhuis
- NIJ Smellinghe
- Diaconessenhuis Eindhoven
- Medisch Spectrum Twente
- St. Anna Ziekenhuis
- Beatrixziekenhuis
- Groene Hart Ziekenhuis
- University Medical Center Groningen
- Martini Ziekenhuis
- Kennemer Gasthuis - Locatie EG
- Spaarne Ziekenhuis Haarlem
- Ziekenhuis St Jansdal
- Tjongerschans Ziekenhuis
- Atrium Medical Centre - Heerlen
- Elkerliek Ziekenhuis
- Streekziekenhuis Midden-Twente
- Westfries Gasthuis
- Zweedse Rode Kruis Ziekenhuis
- Medisch Centrum Leeuwarden - Zuid
- Leiden University Medical Center
- Diaconessenhuis Leiden
- Rijnland Ziekenhuis
- Medisch Centrum Haaglanden Antoniushove
- Academisch Ziekenhuis Maastricht
- Nederlandse Hervormde Diaconessenhuisinrichting
- Sint Antonius Ziekenhuis
- Nijmegen Cancer Center at Radboud University Medical Center
- Ziekenhuis Bernhoven
- Waterlandziekenhuis
- Saint Laurentius Ziekenhuis
- Saint Franciscus Ziekenhuis
- University Medical Center Rotterdam at Erasmus Medical Center
- St. Franciscus Gasthuis
- Medisch Centrum Rynmond-Zuid - Lokatie Zuider
- Medisch Centrum Rynmond Zuid - Lokatie: Clara
- Havenziekenhiuis
- Ikazia Ziekenhuis
- Maasland Hospital
- Albert Schweitzerziekenhuis- Sliedrecht
- Ruwaard Van Putten Ziekenhuis
- Ziekenhuis Refaja
- Ziekenhuis de Honte
- Rivierenland Tiel
- St. Elisabeth Ziekenhuis
- Twee Steden Ziekenhuis Vestiging Tilburg
- University Medical Center Utrecht
- Mesos Medisch Centrum - Overvecht
- Oudenrijn Ziekenhuis
- St. Joseph Veghel
- Maxima Medisch Centrum - locatie Eindhoven
- Holy-Ziekenhuis
- Reinier de Graaf Group - Voorburg
- St. Jans Gasthuis Weert
- Hofpoort Ziekenhuis
- Zaans Medisch Centrum
- Lorentz Ziekenhuis
- 'T Lange Land Ziekenhuis
- Isala Klinieken - locatie Sophia
- Isala Klinieken - locatie Weezenlanden
- University of Auckland School of Medicine
- Christchurch Hospital
- Waikato Hospital
- Haukeland Hospital - University of Bergen
- Norwegian Radium Hospital
- St. Olavs University Hospital
- Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
- Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, S.A.
- National Cancer Institute - Bratislava
- Institute of Oncology - Ljubljana
- Mary Potter Oncology Centre
- Sandton Oncology Centre
- Medical Oncology Centre of Rosebank
- Johannesburg General Hospital
- Sahlgrenska University Hospital at Gothenburg University
- University Hospital of Linkoping
- Sunderby Hospital
- Lund University Hospital
- Orebro University Hospital
- Karolinska University Hospital - Huddinge
- Sundsvall Hospital
- Umea Universitet
- Stoke Mandeville Hospital
- Royal United Hospital
- City Hospital - Birmingham
- Birmingham Heartlands Hospital
- Blackpool Victoria Hospital
- Royal Bournemouth Hospital
- Bradford Hospitals NHS Trust
- Bristol Haematology and Oncology Centre
- Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
- Conquest Hospital
- Kent and Canterbury Hospital
- St Helier Hospital
- Cheltenham General Hospital
- Countess of Chester Hospital
- Essex County Hospital
- Doncaster Royal Infirmary
- Russells Hall Hospital
- Royal Devon and Exeter Hospital
- Queen Elizabeth Hospital
- Diana Princess of Wales Hospital
- Royal Free and University College Medical School
- Hinchingbrooke Hospital
- King George Hospital
- Leeds General Infirmary at Leeds Teaching Hospital NHS Trust
- Leicester Royal Infirmary
- Royal Liverpool University Hospital
- Aintree University Hospital
- Saint Bartholomew's Hospital
- Guy's and St. Thomas' Hospitals NHS Foundation Trust
- St. George's Hospital
- St. Georges Hospital Medical School
- Royal Marsden NHS Foundation Trust - London
- University College Hospital
- Clatterbridge Centre for Oncology NHS Trust
- James Cook University Hospital
- Newcastle Upon Tyne Hospitals NHS Trust
- Mount Vernon Cancer Centre at Mount Vernon Hospital
- Norfolk and Norwich University Hospital
- Oxford Radcliffe Hospital
- Portsmouth Hospitals NHS Trust
- Whiston Hospital
- Royal Preston Hospital
- Berkshire Cancer Centre at Royal Berkshire Hospital
- Oldchurch Hospital
- Pembury Hospital
- Salisbury District Hospital
- Scunthorpe General Hospital
- Cancer Research Centre at Weston Park Hospital
- Southampton General Hospital
- North Staffs Royal Infirmary
- Royal Marsden NHS Foundation Trust - Surrey
- Singleton Hospital
- Taunton and Somerset Hospital
- Torbay Hospital
- Hillingdon Hospital
- Sandwell General Hospital
- Royal Hampshire County Hospital
- New Cross Hospital
- Belfast City Hospital Trust
- Western General Hospital
- Western Infirmary
- Royal Infirmary - Castle
- Southern General Hospital
- Velindre Cancer Center at Velinde Hospital
- University Hospital of Wales
- Royal Gwent Hospital
- Glan Clywd District General Hospital
- Saint Richards Hospital
- Hull Royal Infirmary
- Kettering General Hosptial
- Staffordshire General Hospital
- Great Western Hospital
Outcomes
Primary Outcome Measures
Response to treatment
Secondary Outcome Measures
Overall survival
Progression Free survival
Full Information
NCT ID
NCT00004179
First Posted
January 21, 2000
Last Updated
February 11, 2021
Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Collaborators
Lymphoma Trials Office, Stichting Hemato-Oncologie voor Volwassenen Nederland, Australasian Leukaemia and Lymphoma Group, NCIC Clinical Trials Group, Nordic Lymphoma Group
1. Study Identification
Unique Protocol Identification Number
NCT00004179
Brief Title
Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
Official Title
Chimeric Anti-CD20 Monoclonal Antibody (Mabthera) in Remission Induction and Maintenance Treatment of Relapsed Follicular Non-Hodgkin's Lymphoma: A Phase III Randomized Clinical Trial - Intergroup Collaborative Study
Study Type
Interventional
2. Study Status
Record Verification Date
February 2021
Overall Recruitment Status
Completed
Study Start Date
May 1999 (Actual)
Primary Completion Date
April 2004 (Actual)
Study Completion Date
July 19, 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Collaborators
Lymphoma Trials Office, Stichting Hemato-Oncologie voor Volwassenen Nederland, Australasian Leukaemia and Lymphoma Group, NCIC Clinical Trials Group, Nordic Lymphoma Group
4. Oversight
5. Study Description
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. It is not yet known whether chemotherapy is more effective with or without rituximab for relapsed non-Hodgkin's lymphoma.
PURPOSE: This randomized phase III trial is studying combination chemotherapy and rituximab to see how well they work compared to combination chemotherapy alone in treating patients with relapsed non-Hodgkin's lymphoma.
Detailed Description
OBJECTIVES:
Compare the response rate and quality of remission in patients with relapsed follicular non-Hodgkin's lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without rituximab.
Compare the event-free survival and overall survival of patients treated with these regimens.
Determine the effect of rituximab as maintenance therapy on progression-free survival of these patients.
OUTLINE: This is a randomized, multicenter study.
Induction: Patients are randomized to one of two treatment arms. Patients are stratified according to participating center, prior treatment with purine analogues, age, number of prior induction treatments and best response obtained (complete vs partial remission vs no change/progressive disease), time since diagnosis (less than 2 years vs more than 2 years), and bulky disease (less than 10 cm vs greater than 10 cm).
Arm I (closed as of 12/20/04): Patients receive induction chemotherapy comprising cyclophosphamide IV, doxorubicin IV, and vincristine IV on day 1 and oral prednisone on days 1-5 (CHOP chemotherapy). Treatment repeats every 3 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.
Arm II: Patients receive CHOP chemotherapy as in arm I. Rituximab IV is administered 1 hour after prednisone and before the IV drugs.
Maintenance: Patients who achieve partial or complete remission are then randomized to one of two treatment arms. Patients are stratified according to rituximab administration during induction (yes vs no), quality of the response (complete vs partial remission vs no change/progressive disease), and participating center.
Arm I: Patients receive no further therapy.
Arm II: Beginning 8 weeks after the last CHOP course, patients receive rituximab IV once every 3 months for up to 2 years in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 2 years and then every 4 months thereafter.
PROJECTED ACCRUAL: A total of 752 patients will be accrued for this study within 6 years.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Lymphoma
Keywords
stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Allocation
Randomized
Enrollment
475 (Actual)
8. Arms, Groups, and Interventions
Intervention Type
Biological
Intervention Name(s)
rituximab
Intervention Type
Drug
Intervention Name(s)
CHOP regimen
Intervention Type
Drug
Intervention Name(s)
cyclophosphamide
Intervention Type
Drug
Intervention Name(s)
doxorubicin hydrochloride
Intervention Type
Drug
Intervention Name(s)
prednisone
Intervention Type
Drug
Intervention Name(s)
vincristine sulfate
Primary Outcome Measure Information:
Title
Response to treatment
Secondary Outcome Measure Information:
Title
Overall survival
Time Frame
from randomization
Title
Progression Free survival
Time Frame
from randomization
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
120 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS:
Histologically or cytologically proven stage III or IV follicular non-Hodgkin's lymphoma (NHL)
Relapsed after or no response (no change/progressive disease) to no more than 2 adequate non-anthracycline-containing systemic chemotherapy regimens
At least 2 months of single-agent therapy (e.g., chlorambucil) AND/OR
At least 2 consecutive courses of polychemotherapy (e.g., cyclophosphamide, vincristine, and prednisone) or purine analogues
Complete or partial remission or no change for at least 4 weeks after completion of prior therapy OR progression during one of a maximum of 2 prior therapy regimens
CD20 positive
At least 1 bidimensionally measurable mass
No greater than 10,000,000/mL circulating tumor cells
IgG levels at least 3 g/L
No low-grade NHL transformed into intermediate- or high-grade NHL
No symptomatic CNS lymphoma
No bone marrow involvement only NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology.
PATIENT CHARACTERISTICS:
Age:
18 and over
Performance status:
WHO 0-2
Life expectancy:
Not specified
Hematopoietic:
Not specified
Hepatic:
Bilirubin less than 2.5 times upper limit of normal (ULN)
Alkaline phosphatase less than 2.5 times ULN
Renal:
Creatinine less than 2.5 times ULN
BUN less than 2.5 times ULN
Cardiovascular:
No severe cardiac disease (i.e., severe heart failure requiring symptomatic treatment)
Pulmonary:
No severe pulmonary disease
Other:
No severe neurologic or psychiatric disease
No severe metabolic disease
Not pregnant
Fertile patients must use effective contraception
No prior malignancy within the past 5 years except nonmelanomatous skin cancer, carcinoma in situ of the cervix, or other cancer curatively treated with surgical therapy
HIV negative
No uncontrolled asthma or allergy requiring steroids
No known hypersensitivity or prior anaphylactic reaction to murine proteins or any component of study drug
PRIOR CONCURRENT THERAPY:
Biologic therapy:
No prior rituximab
No prior allogeneic or autologous peripheral blood stem cell transplantation
Concurrent filgrastim (G-CSF) for stem cell mobilization allowed
Chemotherapy:
See Disease Characteristics
No prior anthracyclines or mitoxantrone
No concurrent chemotherapy for stem cell mobilization
Endocrine therapy:
Not specified
Radiotherapy:
Not specified
Surgery:
Not specified
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
M. H. J. Van Oers, MD
Organizational Affiliation
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Robert Marcus, MD
Organizational Affiliation
Cambridge University Hospitals NHS Foundation Trust
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Max M. Wolf, MD
Organizational Affiliation
Peter MacCallum Cancer Centre, Australia
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Richard J. Klasa, MD
Organizational Affiliation
British Columbia Cancer Agency
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Eva K. Kimby, MD, PhD
Organizational Affiliation
Karolinska Institutet
Official's Role
Study Chair
Facility Information:
Facility Name
Canberra Hospital
City
Garran
State/Province
Australian Capital Territory
ZIP/Postal Code
2605
Country
Australia
Facility Name
Concord Repatriation General Hospital
City
Concord
State/Province
New South Wales
ZIP/Postal Code
2139
Country
Australia
Facility Name
Cancer Therapy Centre at Liverpool Hospital
City
Liverpool
State/Province
New South Wales
ZIP/Postal Code
2170
Country
Australia
Facility Name
Institute of Oncology at Prince of Wales Hospital
City
Randwick
State/Province
New South Wales
ZIP/Postal Code
2031
Country
Australia
Facility Name
Prince of Wales Private Hospital
City
Randwick
State/Province
New South Wales
ZIP/Postal Code
NSW 2031
Country
Australia
Facility Name
Royal North Shore Hospital
City
St. Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Facility Name
St. Vincent's Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Facility Name
Sydney Cancer Centre at Royal Prince Alfred Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2050
Country
Australia
Facility Name
St. George Hospital and Community Health Service
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2217
Country
Australia
Facility Name
Westmead Breast Centre at NSW Breast Cancer Institute
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Facility Name
Westmead Hospital
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Facility Name
Wollongong Hospital
City
Wollongong
State/Province
New South Wales
ZIP/Postal Code
2500
Country
Australia
Facility Name
Wesley Medical Centre
City
Auchenflower
State/Province
Queensland
ZIP/Postal Code
4066
Country
Australia
Facility Name
Royal Brisbane and Women's Hospital
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Facility Name
Princess Alexandra Hospital
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Facility Name
Greenslopes Private Hospital
City
Greenslopes
State/Province
Queensland
ZIP/Postal Code
4120
Country
Australia
Facility Name
Townsville General Hospital
City
Townsville
State/Province
Queensland
ZIP/Postal Code
4810
Country
Australia
Facility Name
Royal Adelaide Hospital Cancer Centre
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Ashford Cancer Centre
City
Ashford
State/Province
South Australia
ZIP/Postal Code
5035
Country
Australia
Facility Name
Flinder Medical Centres
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Facility Name
Queen Elizabeth Hospital
City
Woodville
State/Province
South Australia
ZIP/Postal Code
5011
Country
Australia
Facility Name
Royal Hobart Hospital
City
Hobart
State/Province
Tasmania
ZIP/Postal Code
7000
Country
Australia
Facility Name
St. John of God Hospital
City
Ballarat
State/Province
Victoria
ZIP/Postal Code
3350
Country
Australia
Facility Name
Box Hill Hospital
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
John Fawkner Hospital
City
Coburg
State/Province
Victoria
ZIP/Postal Code
3058
Country
Australia
Facility Name
Peter MacCallum Cancer Centre
City
East Melbourne
State/Province
Victoria
ZIP/Postal Code
8006
Country
Australia
Facility Name
St. Vincent's Hospital
City
Fitzroy
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
Facility Name
Frankston Hospital
City
Frankston
State/Province
Victoria
ZIP/Postal Code
3199
Country
Australia
Facility Name
Geelong Hospital
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3200
Country
Australia
Facility Name
Austin Hospital
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Alfred Hospital
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3181
Country
Australia
Facility Name
Garden Consulting Rooms
City
Mornington
State/Province
Victoria
ZIP/Postal Code
3931
Country
Australia
Facility Name
Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
Fremantle Hospital
City
Fremantle
State/Province
Western Australia
ZIP/Postal Code
6160
Country
Australia
Facility Name
Mount Medical Centre
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
Royal Perth Hospital
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
Sir Charles Gairdner Hospital - Perth
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
Ziekenhuis Netwerk Antwerpen Middelheim
City
Antwerp
ZIP/Postal Code
2020
Country
Belgium
Facility Name
Institut Jules Bordet
City
Brussels
ZIP/Postal Code
1000
Country
Belgium
Facility Name
Universitair Ziekenhuis Antwerpen
City
Edegem
ZIP/Postal Code
B-2650
Country
Belgium
Facility Name
Algemeen Ziekenhuis Sint Lucas
City
Ghent
ZIP/Postal Code
B-9000
Country
Belgium
Facility Name
U.Z. Gasthuisberg
City
Leuven
ZIP/Postal Code
B-3000
Country
Belgium
Facility Name
H. Hartziekenhuis - Roeselaere.
City
Roeselare
ZIP/Postal Code
8800
Country
Belgium
Facility Name
Algemeen Ziekenhuis Sint-Augustinus
City
Wilrijk
ZIP/Postal Code
2610
Country
Belgium
Facility Name
Tom Baker Cancer Centre - Calgary
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4N2
Country
Canada
Facility Name
Cross Cancer Institute at University of Alberta
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 1Z2
Country
Canada
Facility Name
British Columbia Cancer Agency - Centre for the Southern Interior
City
Kelowna
State/Province
British Columbia
ZIP/Postal Code
V1Y 5L3
Country
Canada
Facility Name
Nanaimo Cancer Clinic at Nanaimo Regional General Hospital
City
Nanaimo
State/Province
British Columbia
ZIP/Postal Code
V9S 2B7
Country
Canada
Facility Name
Lions Gate Hospital
City
North Vancouver
State/Province
British Columbia
ZIP/Postal Code
V7L 2P9
Country
Canada
Facility Name
Fraser Valley Cancer Centre at British Columbia Cancer Agency
City
Surrey
State/Province
British Columbia
ZIP/Postal Code
V3V 1Z2
Country
Canada
Facility Name
British Columbia Cancer Agency - Vancouver Cancer Centre
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 4E6
Country
Canada
Facility Name
CancerCare Manitoba
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3E 0V9
Country
Canada
Facility Name
Moncton Hospital
City
Moncton
State/Province
New Brunswick
ZIP/Postal Code
E1C 6ZB
Country
Canada
Facility Name
Newfoundland Cancer Treatment and Research Foundation
City
St. Johns
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1B 3V6
Country
Canada
Facility Name
Nova Scotia Cancer Centre at Queen Elizabeth II Health Sciences Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 1V7
Country
Canada
Facility Name
Royal Victoria Hospital of Barrie
City
Barrie
State/Province
Ontario
ZIP/Postal Code
L4M 6M2
Country
Canada
Facility Name
Margaret and Charles Juravinski Cancer Centre
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8V 5C2
Country
Canada
Facility Name
Cancer Centre of Southeastern Ontario at Kingston General Hospital
City
Kingston
State/Province
Ontario
ZIP/Postal Code
K7L 5P9
Country
Canada
Facility Name
London Regional Cancer Program at London Health Sciences Centre
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 4L6
Country
Canada
Facility Name
Trillium Health Centre - Mississauga Site
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L5B 1B8
Country
Canada
Facility Name
Ottawa Hospital Regional Cancer Centre - General Campus
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 1C4
Country
Canada
Facility Name
Hotel Dieu Health Sciences Hospital - Niagara
City
St. Catharines
State/Province
Ontario
ZIP/Postal Code
L2R 5K3
Country
Canada
Facility Name
Northeastern Ontario Regional Cancer Centre
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3E 5J1
Country
Canada
Facility Name
Northwestern Ontario Regional Cancer Care at Thunder Bay Regional Health Sciences Centre
City
Thunder Bay
State/Province
Ontario
ZIP/Postal Code
P7A 7T1
Country
Canada
Facility Name
Toronto Sunnybrook Regional Cancer Centre at Sunnybrook and Women's College Health Sciences Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Facility Name
Princess Margaret Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2M9
Country
Canada
Facility Name
St. Joseph's Health Centre - Toronto
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6R 1B5
Country
Canada
Facility Name
Humber River Regional Hospital - Weston
City
Weston
State/Province
Ontario
ZIP/Postal Code
M9N 1N8
Country
Canada
Facility Name
Windsor Regional Cancer Centre at Windsor Regional Hospital
City
Windsor
State/Province
Ontario
ZIP/Postal Code
N8W 2X3
Country
Canada
Facility Name
Hopital Charles Lemoyne
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
Facility Name
Maisonneuve-Rosemont Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Facility Name
McGill Cancer Centre at McGill University
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2W 1S6
Country
Canada
Facility Name
Hopital Du Sacre-Coeur de Montreal
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4J 1C5
Country
Canada
Facility Name
Hopital Notre- Dame du CHUM
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H4L 2M1
Country
Canada
Facility Name
Hopital du Saint-Sacrement, Quebec
City
Quebec City
State/Province
Quebec
ZIP/Postal Code
G1S 4L8
Country
Canada
Facility Name
Allan Blair Cancer Centre at Pasqua Hospital
City
Regina
State/Province
Saskatchewan
ZIP/Postal Code
S4T 7T1
Country
Canada
Facility Name
Rigshospitalet - Copenhagen University Hospital
City
Copenhagen
ZIP/Postal Code
2100
Country
Denmark
Facility Name
Vejle Sygehus
City
Vejle
ZIP/Postal Code
7100
Country
Denmark
Facility Name
National Cancer Institute of Egypt
City
Cairo
Country
Egypt
Facility Name
Institut Bergonie
City
Bordeaux
ZIP/Postal Code
33076
Country
France
Facility Name
Institut Gustave Roussy
City
Villejuif
ZIP/Postal Code
F-94805
Country
France
Facility Name
National Institute of Oncology
City
Budapest
ZIP/Postal Code
1125
Country
Hungary
Facility Name
Centro di Riferimento Oncologico - Aviano
City
Aviano
ZIP/Postal Code
33081
Country
Italy
Facility Name
Hagaziekenhuis
City
's-Gravenhage
ZIP/Postal Code
2545 CH
Country
Netherlands
Facility Name
Jeroen Bosch Ziekenhuis
City
's-Hertogenbosch
ZIP/Postal Code
5211 NL
Country
Netherlands
Facility Name
Medisch Centrum Alkmaar
City
Alkmaar
ZIP/Postal Code
1815 JD
Country
Netherlands
Facility Name
Ijselmeer Ziekenhuis - Zuiderzeeziekenhuis
City
Almere
ZIP/Postal Code
1315RA
Country
Netherlands
Facility Name
Meander Medisch Centrum
City
Amersfont
ZIP/Postal Code
3016 CP
Country
Netherlands
Facility Name
St. Lucas - Andreas Ziekenhuis
City
Amsterdam
ZIP/Postal Code
1006 AE
Country
Netherlands
Facility Name
Vrije Universiteit Medisch Centrum
City
Amsterdam
ZIP/Postal Code
1007 MB
Country
Netherlands
Facility Name
Boveny Ziekenhuis
City
Amsterdam
ZIP/Postal Code
1034 CS
Country
Netherlands
Facility Name
Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
City
Amsterdam
ZIP/Postal Code
1066 CX
Country
Netherlands
Facility Name
Slotervaart Ziekenhuis
City
Amsterdam
ZIP/Postal Code
1066 EC
Country
Netherlands
Facility Name
Onze Lieve Vrouwe Gasthuis
City
Amsterdam
ZIP/Postal Code
1091 HA
Country
Netherlands
Facility Name
Academisch Medisch Centrum at University of Amsterdam
City
Amsterdam
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
Albert Schweitzerziekenhuis- Zwijndrecht
City
Amsterdam
Country
Netherlands
Facility Name
Scheperziekenhuis
City
Amsterdam
Country
Netherlands
Facility Name
Gelre Ziekenhuizen - Lokatie Lukas
City
Apeldoorn
ZIP/Postal Code
7334 DZ
Country
Netherlands
Facility Name
Ziekenhuis Lievensberg
City
Bergen-op-Zoom
ZIP/Postal Code
4624 VT
Country
Netherlands
Facility Name
Streekziekenhuis Gooi-Noord
City
Blaricum
ZIP/Postal Code
1261 AN
Country
Netherlands
Facility Name
Amphia Ziekenhuis - locatie Langendijk
City
Breda
ZIP/Postal Code
4800 RL
Country
Netherlands
Facility Name
Amphia Ziekenhuis - locatie Molengracht
City
Breda
ZIP/Postal Code
4818 CK
Country
Netherlands
Facility Name
Atrium Medical Centre - Brunssum
City
Brunssum
ZIP/Postal Code
6442 BE
Country
Netherlands
Facility Name
Ijsselland Ziekenhuis
City
Capelle aan den Ijssel
ZIP/Postal Code
2906 ZC
Country
Netherlands
Facility Name
Reinier de Graaf Group - Delft
City
Delft
ZIP/Postal Code
NL 2600 GA
Country
Netherlands
Facility Name
Red Cross Hospital
City
Den Haag
ZIP/Postal Code
2566 MJ
Country
Netherlands
Facility Name
Gemini Ziekenhuis
City
Den Helder
ZIP/Postal Code
1782 GZ
Country
Netherlands
Facility Name
Deventer Ziekenhuisen
City
Deventer
ZIP/Postal Code
7415 CM
Country
Netherlands
Facility Name
Van Weel Bethesda Ziekenhuis
City
Dirksland
ZIP/Postal Code
3247 BW
Country
Netherlands
Facility Name
NIJ Smellinghe
City
Drachten
ZIP/Postal Code
NL-9200 DA
Country
Netherlands
Facility Name
Diaconessenhuis Eindhoven
City
Eindhoven
ZIP/Postal Code
5631 BM
Country
Netherlands
Facility Name
Medisch Spectrum Twente
City
Enschede
ZIP/Postal Code
7500 KA
Country
Netherlands
Facility Name
St. Anna Ziekenhuis
City
Geldrop
ZIP/Postal Code
NL-5664
Country
Netherlands
Facility Name
Beatrixziekenhuis
City
Gorinchem
Country
Netherlands
Facility Name
Groene Hart Ziekenhuis
City
Gouda
ZIP/Postal Code
2803 HH
Country
Netherlands
Facility Name
University Medical Center Groningen
City
Groningen
ZIP/Postal Code
9713 GZ
Country
Netherlands
Facility Name
Martini Ziekenhuis
City
Groningen
Country
Netherlands
Facility Name
Kennemer Gasthuis - Locatie EG
City
Haarlem
ZIP/Postal Code
2000
Country
Netherlands
Facility Name
Spaarne Ziekenhuis Haarlem
City
Haarlem
ZIP/Postal Code
2012 CE
Country
Netherlands
Facility Name
Ziekenhuis St Jansdal
City
Harderwijk
ZIP/Postal Code
3840 AC
Country
Netherlands
Facility Name
Tjongerschans Ziekenhuis
City
Heerenveen
ZIP/Postal Code
8440 MA
Country
Netherlands
Facility Name
Atrium Medical Centre - Heerlen
City
Heerlen
ZIP/Postal Code
6419 PC
Country
Netherlands
Facility Name
Elkerliek Ziekenhuis
City
Helmond
ZIP/Postal Code
5707-HA
Country
Netherlands
Facility Name
Streekziekenhuis Midden-Twente
City
Hengelo
ZIP/Postal Code
7555 DL
Country
Netherlands
Facility Name
Westfries Gasthuis
City
Hoorn
ZIP/Postal Code
1624 AR
Country
Netherlands
Facility Name
Zweedse Rode Kruis Ziekenhuis
City
La Zierikzee
ZIP/Postal Code
NL-4300
Country
Netherlands
Facility Name
Medisch Centrum Leeuwarden - Zuid
City
Leeuwarden
ZIP/Postal Code
8934 AD
Country
Netherlands
Facility Name
Leiden University Medical Center
City
Leiden
ZIP/Postal Code
2300 CA
Country
Netherlands
Facility Name
Diaconessenhuis Leiden
City
Leiden
ZIP/Postal Code
2300 RD
Country
Netherlands
Facility Name
Rijnland Ziekenhuis
City
Leiderdorp
ZIP/Postal Code
2350 CC
Country
Netherlands
Facility Name
Medisch Centrum Haaglanden Antoniushove
City
Leidschendam
ZIP/Postal Code
2262 BA
Country
Netherlands
Facility Name
Academisch Ziekenhuis Maastricht
City
Maastricht
ZIP/Postal Code
6202 AZ
Country
Netherlands
Facility Name
Nederlandse Hervormde Diaconessenhuisinrichting
City
Meppel
ZIP/Postal Code
NL-7940
Country
Netherlands
Facility Name
Sint Antonius Ziekenhuis
City
Nieuwegein
ZIP/Postal Code
3435 CM
Country
Netherlands
Facility Name
Nijmegen Cancer Center at Radboud University Medical Center
City
Nijmegen
ZIP/Postal Code
NL-6500 HB
Country
Netherlands
Facility Name
Ziekenhuis Bernhoven
City
Oss
ZIP/Postal Code
5340 BE
Country
Netherlands
Facility Name
Waterlandziekenhuis
City
Purmerend
ZIP/Postal Code
1440 AG
Country
Netherlands
Facility Name
Saint Laurentius Ziekenhuis
City
Roermond
ZIP/Postal Code
6043 CV
Country
Netherlands
Facility Name
Saint Franciscus Ziekenhuis
City
Roosendaal
ZIP/Postal Code
4708 AE
Country
Netherlands
Facility Name
University Medical Center Rotterdam at Erasmus Medical Center
City
Rotterdam
ZIP/Postal Code
3000 CA
Country
Netherlands
Facility Name
St. Franciscus Gasthuis
City
Rotterdam
ZIP/Postal Code
3045 PM
Country
Netherlands
Facility Name
Medisch Centrum Rynmond-Zuid - Lokatie Zuider
City
Rotterdam
ZIP/Postal Code
3075 AC
Country
Netherlands
Facility Name
Medisch Centrum Rynmond Zuid - Lokatie: Clara
City
Rotterdam
ZIP/Postal Code
3078 HT
Country
Netherlands
Facility Name
Havenziekenhiuis
City
Rotterdam
ZIP/Postal Code
NL-3000
Country
Netherlands
Facility Name
Ikazia Ziekenhuis
City
Rotterdam
ZIP/Postal Code
NL-3083
Country
Netherlands
Facility Name
Maasland Hospital
City
Sittard
ZIP/Postal Code
6131 BK
Country
Netherlands
Facility Name
Albert Schweitzerziekenhuis- Sliedrecht
City
Sliedrecht
ZIP/Postal Code
NL-336
Country
Netherlands
Facility Name
Ruwaard Van Putten Ziekenhuis
City
Spykenisse
ZIP/Postal Code
NL-3200 GA
Country
Netherlands
Facility Name
Ziekenhuis Refaja
City
Stadskanaal
ZIP/Postal Code
NL-9501
Country
Netherlands
Facility Name
Ziekenhuis de Honte
City
Terneuzen
ZIP/Postal Code
NL-4535
Country
Netherlands
Facility Name
Rivierenland Tiel
City
Tiel
ZIP/Postal Code
NL-4000
Country
Netherlands
Facility Name
St. Elisabeth Ziekenhuis
City
Tilburg
ZIP/Postal Code
5022 GC
Country
Netherlands
Facility Name
Twee Steden Ziekenhuis Vestiging Tilburg
City
Tilburg
ZIP/Postal Code
5042 AD
Country
Netherlands
Facility Name
University Medical Center Utrecht
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Facility Name
Mesos Medisch Centrum - Overvecht
City
Utrecht
ZIP/Postal Code
NL-3563
Country
Netherlands
Facility Name
Oudenrijn Ziekenhuis
City
Utrecht
Country
Netherlands
Facility Name
St. Joseph Veghel
City
Veghel
ZIP/Postal Code
NL-5461
Country
Netherlands
Facility Name
Maxima Medisch Centrum - locatie Eindhoven
City
Veldhoven
ZIP/Postal Code
5500 MB
Country
Netherlands
Facility Name
Holy-Ziekenhuis
City
Vlaardingen
ZIP/Postal Code
NL-3130 GA
Country
Netherlands
Facility Name
Reinier de Graaf Group - Voorburg
City
Voorburg
ZIP/Postal Code
2275 CX
Country
Netherlands
Facility Name
St. Jans Gasthuis Weert
City
Weert Be
ZIP/Postal Code
6001
Country
Netherlands
Facility Name
Hofpoort Ziekenhuis
City
Woerden
ZIP/Postal Code
NL-3445
Country
Netherlands
Facility Name
Zaans Medisch Centrum
City
Zaandam
ZIP/Postal Code
1502 DV
Country
Netherlands
Facility Name
Lorentz Ziekenhuis
City
Zeist
ZIP/Postal Code
NL-3700
Country
Netherlands
Facility Name
'T Lange Land Ziekenhuis
City
Zoetermeer
ZIP/Postal Code
NL-2700
Country
Netherlands
Facility Name
Isala Klinieken - locatie Sophia
City
Zwolle
ZIP/Postal Code
8000 GK
Country
Netherlands
Facility Name
Isala Klinieken - locatie Weezenlanden
City
Zwolle
ZIP/Postal Code
NL-8000 GM
Country
Netherlands
Facility Name
University of Auckland School of Medicine
City
Auckland
ZIP/Postal Code
3
Country
New Zealand
Facility Name
Christchurch Hospital
City
Christchurch
ZIP/Postal Code
1
Country
New Zealand
Facility Name
Waikato Hospital
City
Hamilton
ZIP/Postal Code
2020
Country
New Zealand
Facility Name
Haukeland Hospital - University of Bergen
City
Bergen
ZIP/Postal Code
N-5021
Country
Norway
Facility Name
Norwegian Radium Hospital
City
Oslo
ZIP/Postal Code
N-0310
Country
Norway
Facility Name
St. Olavs University Hospital
City
Trondheim
ZIP/Postal Code
7006
Country
Norway
Facility Name
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
City
Warsaw
ZIP/Postal Code
02-781
Country
Poland
Facility Name
Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, S.A.
City
Lisbon
ZIP/Postal Code
1099-023 Codex
Country
Portugal
Facility Name
National Cancer Institute - Bratislava
City
Bratislava
ZIP/Postal Code
833 10
Country
Slovakia
Facility Name
Institute of Oncology - Ljubljana
City
Ljubljana
ZIP/Postal Code
Sl-1000
Country
Slovenia
Facility Name
Mary Potter Oncology Centre
City
Brooklyn Square
ZIP/Postal Code
1577
Country
South Africa
Facility Name
Sandton Oncology Centre
City
Johannesburg
ZIP/Postal Code
2121
Country
South Africa
Facility Name
Medical Oncology Centre of Rosebank
City
Johannesburg
ZIP/Postal Code
2193
Country
South Africa
Facility Name
Johannesburg General Hospital
City
Parktown
ZIP/Postal Code
2193
Country
South Africa
Facility Name
Sahlgrenska University Hospital at Gothenburg University
City
Gothenburg (Goteborg)
ZIP/Postal Code
S-413 45
Country
Sweden
Facility Name
University Hospital of Linkoping
City
Linkoping
ZIP/Postal Code
S-581 85
Country
Sweden
Facility Name
Sunderby Hospital
City
Lulea
ZIP/Postal Code
95128
Country
Sweden
Facility Name
Lund University Hospital
City
Lund
ZIP/Postal Code
S-22185
Country
Sweden
Facility Name
Orebro University Hospital
City
Orebro
ZIP/Postal Code
70185
Country
Sweden
Facility Name
Karolinska University Hospital - Huddinge
City
Stockholm
ZIP/Postal Code
S-141 86
Country
Sweden
Facility Name
Sundsvall Hospital
City
Sundsvall
ZIP/Postal Code
85186
Country
Sweden
Facility Name
Umea Universitet
City
Umea
ZIP/Postal Code
S-901 85
Country
Sweden
Facility Name
Stoke Mandeville Hospital
City
Aylesbury-Buckinghamshire
State/Province
England
ZIP/Postal Code
HP21 8AL
Country
United Kingdom
Facility Name
Royal United Hospital
City
Bath
State/Province
England
ZIP/Postal Code
BA1 3NG
Country
United Kingdom
Facility Name
City Hospital - Birmingham
City
Birmingham
State/Province
England
ZIP/Postal Code
B18 7QH
Country
United Kingdom
Facility Name
Birmingham Heartlands Hospital
City
Birmingham
State/Province
England
ZIP/Postal Code
B9 5SS
Country
United Kingdom
Facility Name
Blackpool Victoria Hospital
City
Blackpool
State/Province
England
ZIP/Postal Code
FY3 8NR
Country
United Kingdom
Facility Name
Royal Bournemouth Hospital
City
Bournemouth
State/Province
England
ZIP/Postal Code
BH7 7DW
Country
United Kingdom
Facility Name
Bradford Hospitals NHS Trust
City
Bradford
State/Province
England
ZIP/Postal Code
BD9 6RJ
Country
United Kingdom
Facility Name
Bristol Haematology and Oncology Centre
City
Bristol
State/Province
England
ZIP/Postal Code
BS2 8ED
Country
United Kingdom
Facility Name
Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
City
Cambridge
State/Province
England
ZIP/Postal Code
CB2 2QQ
Country
United Kingdom
Facility Name
Conquest Hospital
City
Canterbury
State/Province
England
ZIP/Postal Code
CT2 7NR
Country
United Kingdom
Facility Name
Kent and Canterbury Hospital
City
Canterbury
State/Province
England
ZIP/Postal Code
CT2 7NR
Country
United Kingdom
Facility Name
St Helier Hospital
City
Carshalton
State/Province
England
ZIP/Postal Code
SM5 1AA
Country
United Kingdom
Facility Name
Cheltenham General Hospital
City
Cheltenham
State/Province
England
ZIP/Postal Code
GL53 7AN
Country
United Kingdom
Facility Name
Countess of Chester Hospital
City
Chester
State/Province
England
ZIP/Postal Code
CH2 1UL
Country
United Kingdom
Facility Name
Essex County Hospital
City
Colchester
State/Province
England
ZIP/Postal Code
C03 3NB
Country
United Kingdom
Facility Name
Doncaster Royal Infirmary
City
Doncaster
State/Province
England
ZIP/Postal Code
DN2 5LT
Country
United Kingdom
Facility Name
Russells Hall Hospital
City
Dudley
State/Province
England
ZIP/Postal Code
DY1 2HQ
Country
United Kingdom
Facility Name
Royal Devon and Exeter Hospital
City
Exeter
State/Province
England
ZIP/Postal Code
EX2 5DW
Country
United Kingdom
Facility Name
Queen Elizabeth Hospital
City
Gateshead
State/Province
England
ZIP/Postal Code
NE9 6SX
Country
United Kingdom
Facility Name
Diana Princess of Wales Hospital
City
Grimsby
State/Province
England
ZIP/Postal Code
DN33 2BA
Country
United Kingdom
Facility Name
Royal Free and University College Medical School
City
Hampstead, London
State/Province
England
ZIP/Postal Code
NW3 2QG
Country
United Kingdom
Facility Name
Hinchingbrooke Hospital
City
Huntingdon
State/Province
England
ZIP/Postal Code
PE18 6NT
Country
United Kingdom
Facility Name
King George Hospital
City
Ilford, Essex
State/Province
England
ZIP/Postal Code
IG3 8YB
Country
United Kingdom
Facility Name
Leeds General Infirmary at Leeds Teaching Hospital NHS Trust
City
Leeds
State/Province
England
ZIP/Postal Code
LS1 3EX
Country
United Kingdom
Facility Name
Leicester Royal Infirmary
City
Leicester
State/Province
England
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Facility Name
Royal Liverpool University Hospital
City
Liverpool
State/Province
England
ZIP/Postal Code
L69 3GA
Country
United Kingdom
Facility Name
Aintree University Hospital
City
Liverpool
State/Province
England
ZIP/Postal Code
L9 7AL
Country
United Kingdom
Facility Name
Saint Bartholomew's Hospital
City
London
State/Province
England
ZIP/Postal Code
EC1A 7BE
Country
United Kingdom
Facility Name
Guy's and St. Thomas' Hospitals NHS Foundation Trust
City
London
State/Province
England
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Facility Name
St. George's Hospital
City
London
State/Province
England
ZIP/Postal Code
SW17 0QT
Country
United Kingdom
Facility Name
St. Georges Hospital Medical School
City
London
State/Province
England
ZIP/Postal Code
SW17 ORE
Country
United Kingdom
Facility Name
Royal Marsden NHS Foundation Trust - London
City
London
State/Province
England
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Facility Name
University College Hospital
City
London
State/Province
England
ZIP/Postal Code
WC1E 6AU
Country
United Kingdom
Facility Name
Clatterbridge Centre for Oncology NHS Trust
City
Merseyside
State/Province
England
ZIP/Postal Code
CH63 4JY
Country
United Kingdom
Facility Name
James Cook University Hospital
City
Middlesbrough
State/Province
England
ZIP/Postal Code
TS4 3BW
Country
United Kingdom
Facility Name
Newcastle Upon Tyne Hospitals NHS Trust
City
Newcastle-Upon-Tyne
State/Province
England
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Facility Name
Mount Vernon Cancer Centre at Mount Vernon Hospital
City
Northwood
State/Province
England
ZIP/Postal Code
HA6 2RN
Country
United Kingdom
Facility Name
Norfolk and Norwich University Hospital
City
Norwich
State/Province
England
ZIP/Postal Code
NR1 3SR
Country
United Kingdom
Facility Name
Oxford Radcliffe Hospital
City
Oxford
State/Province
England
ZIP/Postal Code
0X3 9DU
Country
United Kingdom
Facility Name
Portsmouth Hospitals NHS Trust
City
Portsmouth
State/Province
England
ZIP/Postal Code
P03 6AD
Country
United Kingdom
Facility Name
Whiston Hospital
City
Prescot Merseyside
State/Province
England
ZIP/Postal Code
L35 5DR
Country
United Kingdom
Facility Name
Royal Preston Hospital
City
Preston
State/Province
England
ZIP/Postal Code
PR2 9HT
Country
United Kingdom
Facility Name
Berkshire Cancer Centre at Royal Berkshire Hospital
City
Reading
State/Province
England
ZIP/Postal Code
RG1 5AN
Country
United Kingdom
Facility Name
Oldchurch Hospital
City
Romford
State/Province
England
ZIP/Postal Code
RM7 OBE
Country
United Kingdom
Facility Name
Pembury Hospital
City
Royal Tunbridge Wells, Kent
State/Province
England
ZIP/Postal Code
TN2 4QJ
Country
United Kingdom
Facility Name
Salisbury District Hospital
City
Salisbury
State/Province
England
ZIP/Postal Code
SP2 8BJ
Country
United Kingdom
Facility Name
Scunthorpe General Hospital
City
Scunthorpe
State/Province
England
ZIP/Postal Code
DN15 7BH
Country
United Kingdom
Facility Name
Cancer Research Centre at Weston Park Hospital
City
Sheffield
State/Province
England
ZIP/Postal Code
S1O 2SJ
Country
United Kingdom
Facility Name
Southampton General Hospital
City
Southampton
State/Province
England
ZIP/Postal Code
SO16 6YD
Country
United Kingdom
Facility Name
North Staffs Royal Infirmary
City
Stoke-On-Trent
State/Province
England
ZIP/Postal Code
ST4 7LN
Country
United Kingdom
Facility Name
Royal Marsden NHS Foundation Trust - Surrey
City
Sutton
State/Province
England
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Facility Name
Singleton Hospital
City
Swansea
State/Province
England
ZIP/Postal Code
SA 2 8QA
Country
United Kingdom
Facility Name
Taunton and Somerset Hospital
City
Taunton Somerset
State/Province
England
ZIP/Postal Code
TA1 5DA
Country
United Kingdom
Facility Name
Torbay Hospital
City
Torquay Devon
State/Province
England
ZIP/Postal Code
TQ2 7AA
Country
United Kingdom
Facility Name
Hillingdon Hospital
City
Uxbridge
State/Province
England
ZIP/Postal Code
UB8 3NN
Country
United Kingdom
Facility Name
Sandwell General Hospital
City
West Bromwich
State/Province
England
ZIP/Postal Code
B71 4HJ
Country
United Kingdom
Facility Name
Royal Hampshire County Hospital
City
Winchester
State/Province
England
ZIP/Postal Code
SO22 5DG
Country
United Kingdom
Facility Name
New Cross Hospital
City
Wolverhampton
State/Province
England
ZIP/Postal Code
WV10 0QP
Country
United Kingdom
Facility Name
Belfast City Hospital Trust
City
Belfast
State/Province
Northern Ireland
ZIP/Postal Code
BT9 7AB
Country
United Kingdom
Facility Name
Western General Hospital
City
Edinburgh
State/Province
Scotland
ZIP/Postal Code
EH4 2XU
Country
United Kingdom
Facility Name
Western Infirmary
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G11 6NT
Country
United Kingdom
Facility Name
Royal Infirmary - Castle
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G4 0SF
Country
United Kingdom
Facility Name
Southern General Hospital
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G51 4TF
Country
United Kingdom
Facility Name
Velindre Cancer Center at Velinde Hospital
City
Cardiff
State/Province
Wales
ZIP/Postal Code
CF14 2TL
Country
United Kingdom
Facility Name
University Hospital of Wales
City
Cardiff
State/Province
Wales
ZIP/Postal Code
CF14 4XN
Country
United Kingdom
Facility Name
Royal Gwent Hospital
City
Newport Gwent
State/Province
Wales
ZIP/Postal Code
NP9 2UB
Country
United Kingdom
Facility Name
Glan Clywd District General Hospital
City
Rhyl, Denbighshire
State/Province
Wales
ZIP/Postal Code
LL 18 5UJ
Country
United Kingdom
Facility Name
Saint Richards Hospital
City
Chichester
ZIP/Postal Code
P019 4SE
Country
United Kingdom
Facility Name
Hull Royal Infirmary
City
Hull
ZIP/Postal Code
HU3 2KZ
Country
United Kingdom
Facility Name
Kettering General Hosptial
City
Kettering, Northants
ZIP/Postal Code
NNI6 8UZ
Country
United Kingdom
Facility Name
Staffordshire General Hospital
City
Stafford
ZIP/Postal Code
ST16 3SA
Country
United Kingdom
Facility Name
Great Western Hospital
City
Swindon,
ZIP/Postal Code
SN1 4JU
Country
United Kingdom
12. IPD Sharing Statement
Citations:
PubMed Identifier
20014875
Citation
Deconinck E, Miadi-Fargier H, Pen CL, Brice P. Cost effectiveness of rituximab maintenance therapy in follicular lymphoma: long-term economic evaluation. Pharmacoeconomics. 2010;28(1):35-46. doi: 10.2165/11314070-000000000-00000.
Results Reference
background
Citation
Pompen M, Huijgens PC, et al.: Cost-effectiveness of rituximab for maintenance in patients with follicular non-Hodgkin's lymphoma in the Dutch setting. [Abstract] Blood 112 (11): A-2364, 2008.
Results Reference
background
PubMed Identifier
12424535
Citation
Van Oers MH, Hagenbeek A, Van Glabbeke M, Teodorovic I. Chimeric anti-CD20 monoclonal antibody (Mabthera) in remission induction and maintenance treatment of relapsed follicular non-Hodgkin's lymphoma: a phase III randomized clinical trial--Intergroup Collaborative Study. Ann Hematol. 2002 Oct;81(10):553-7. doi: 10.1007/s00277-002-0548-2. Epub 2002 Oct 17. No abstract available.
Results Reference
background
PubMed Identifier
20368567
Citation
van Oers MH, Tonnissen E, Van Glabbeke M, Giurgea L, Jansen JH, Klasa R, Marcus RE, Wolf M, Kimby E, Vranovsky A, Holte H, Hagenbeek A, van der Reijden BA. BCL-2/IgH polymerase chain reaction status at the end of induction treatment is not predictive for progression-free survival in relapsed/resistant follicular lymphoma: results of a prospective randomized EORTC 20981 phase III intergroup study. J Clin Oncol. 2010 May 1;28(13):2246-52. doi: 10.1200/JCO.2009.25.0852. Epub 2010 Apr 5.
Results Reference
result
PubMed Identifier
20439641
Citation
van Oers MH, Van Glabbeke M, Giurgea L, Klasa R, Marcus RE, Wolf M, Kimby E, van t Veer M, Vranovsky A, Holte H, Hagenbeek A. Rituximab maintenance treatment of relapsed/resistant follicular non-Hodgkin's lymphoma: long-term outcome of the EORTC 20981 phase III randomized intergroup study. J Clin Oncol. 2010 Jun 10;28(17):2853-8. doi: 10.1200/JCO.2009.26.5827. Epub 2010 May 3.
Results Reference
result
PubMed Identifier
16873669
Citation
van Oers MH, Klasa R, Marcus RE, Wolf M, Kimby E, Gascoyne RD, Jack A, Van't Veer M, Vranovsky A, Holte H, van Glabbeke M, Teodorovic I, Rozewicz C, Hagenbeek A. Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial. Blood. 2006 Nov 15;108(10):3295-301. doi: 10.1182/blood-2006-05-021113. Epub 2006 Jul 27.
Results Reference
result
PubMed Identifier
34384709
Citation
Mattiola I, Mantovani A, Locati M. The tetraspan MS4A family in homeostasis, immunity, and disease. Trends Immunol. 2021 Sep;42(9):764-781. doi: 10.1016/j.it.2021.07.002. Epub 2021 Aug 9.
Results Reference
derived
Learn more about this trial
Combination Chemotherapy With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
We'll reach out to this number within 24 hrs