Back to results

Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome

Primary Purpose

Cushing's Syndrome

Status

Unknown status

Phase

Locations

United States

Study Type

Observational

Intervention

About this trial

This is an observational trial for Cushing's Syndrome focused on measuring Cushing's syndrome, endocrine disorders, rare disease

Eligibility Criteria

0 Years - undefined (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

PROTOCOL ENTRY CRITERIA: Suspected adrenocorticotropin hormone (ACTH)-dependent Cushing's syndrome No pregnant women Effective contraception required of fertile women

Sites / Locations

Oregon Health Sciences University

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

NCT ID

NCT00004343

First Posted

October 18, 1999

Last Updated

June 23, 2005

Sponsor

National Center for Research Resources (NCRR)

Collaborators

Oregon Health and Science University

1. Study Identification

Unique Protocol Identification Number

NCT00004343

Brief Title

Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome

Study Type

Observational

2. Study Status

Record Verification Date

December 2003

Overall Recruitment Status

Unknown status

Study Start Date

October 1999 (undefined)

Primary Completion Date

undefined (undefined)

Study Completion Date

undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor

National Center for Research Resources (NCRR)

Collaborators

Oregon Health and Science University

4. Oversight

5. Study Description

Brief Summary

OBJECTIVES: I. Determine whether Cushing's syndrome and stress-induced pseudo-Cushing's syndrome can be differentiated by evaluating endogenous corticotropin-releasing hormone activity.

Detailed Description

PROTOCOL OUTLINE: Patients undergo a 30-hour infusion of deuterated cortisol with peripheral and petrosal vein measurements of adrenocorticotropin hormone (ACTH) and corticotropin-releasing hormone (CRH). Patients also have a 2-day, low-dose dexamethasone suppression test. Patients with ACTH tumors are referred for pituitary surgery as indicated. Patients without Cushing's syndrome are entered as controls. During scheduled radiologic procedures, these subjects undergo ACTH and CRH sampling from the petrosal vein or cavernous sinus following a deuterated cortisol infusion.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Cushing's Syndrome

Keywords

Cushing's syndrome, endocrine disorders, rare disease

7. Study Design

Enrollment

40 (false)

10. Eligibility

Sex

All

Minimum Age & Unit of Time

0 Years

Accepts Healthy Volunteers

Eligibility Criteria

PROTOCOL ENTRY CRITERIA: Suspected adrenocorticotropin hormone (ACTH)-dependent Cushing's syndrome No pregnant women Effective contraception required of fertile women

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Mary H. Samuels

Organizational Affiliation

Oregon Health and Science University

Official's Role

Study Chair

Facility Information:

Facility Name

Oregon Health Sciences University

City

Portland

State/Province

Oregon

ZIP/Postal Code

97201-3098

Country

United States

12. IPD Sharing Statement

Learn more about this trial

Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome

We'll reach out to this number within 24 hrs