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Study of Novel Types of Familial Diabetes Insipidus

Primary Purpose

Diabetes Insipidus

Status

Unknown status

Phase

Locations

Study Type

Observational

Intervention

desmopressin

About this trial

This is an observational trial for Diabetes Insipidus focused on measuring diabetes insipidus, endocrine disorders, rare disease

Eligibility Criteria

6 Months - 70 Years (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Familial diabetes insipidus (DI) in atypical or novel form, e.g.: Dipsogenic DI Neurohypophyseal DI Affected and unaffected members of kindreds eligible

Sites / Locations

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

NCT ID

NCT00004364

First Posted

October 18, 1999

Last Updated

February 21, 2006

Sponsor

National Center for Research Resources (NCRR)

Collaborators

Northwestern University

1. Study Identification

Unique Protocol Identification Number

NCT00004364

Brief Title

Study of Novel Types of Familial Diabetes Insipidus

Study Type

Observational

2. Study Status

Record Verification Date

February 2006

Overall Recruitment Status

Unknown status

Study Start Date

December 1995 (undefined)

Primary Completion Date

undefined (undefined)

Study Completion Date

undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor

National Center for Research Resources (NCRR)

Collaborators

Northwestern University

4. Oversight

5. Study Description

Brief Summary

OBJECTIVES: I. Define the phenotype and genotype of previously unrecognized types of familial diabetes insipidus (FDI) in kindreds with atypical or novel forms of FDI.

Detailed Description

PROTOCOL OUTLINE: Participants undergo a series of tests to determine the presence, absence, cause, natural history, clinical status, and mode of inheritance of their type of diabetes insipidus (DI). The studies include measurements of basal fluid intake and urine output, plasma vasopressin during standard fluid deprivation or waterload/saline infusion tests, and changes in water balance during a therapeutic trial of DDAVP. If clinically indicated, echocardiograms and assays of plasma catecholes and renin are also completed. Linkage analysis is performed for all participants; kindreds with the Marfan-like syndrome are also studied for the fibrillin-1 genotype. Participants determined to have DI are treated with desmopressin for 2 days.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Diabetes Insipidus

Keywords

diabetes insipidus, endocrine disorders, rare disease

7. Study Design

Enrollment

5 (false)

8. Arms, Groups, and Interventions

Intervention Type

Drug

Intervention Name(s)

desmopressin

10. Eligibility

Sex

All

Minimum Age & Unit of Time

6 Months

Maximum Age & Unit of Time

70 Years

Accepts Healthy Volunteers

Eligibility Criteria

Familial diabetes insipidus (DI) in atypical or novel form, e.g.: Dipsogenic DI Neurohypophyseal DI Affected and unaffected members of kindreds eligible

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Gary L. Robertson

Organizational Affiliation

Northwestern University

Official's Role

Study Chair

12. IPD Sharing Statement

Learn more about this trial

Study of Novel Types of Familial Diabetes Insipidus

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