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Ultraviolet Light Therapy for Systemic Lupus Erythematosus

Primary Purpose

Systemic Lupus Erythematosus

Status
Unknown status
Phase
Phase 2
Locations
United States
Study Type
Interventional
Intervention
ultraviolet A-1 light treatment
Sponsored by
National Center for Research Resources (NCRR)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an interventional treatment trial for Systemic Lupus Erythematosus focused on measuring arthritis & connective tissue diseases, immunologic disorders and infectious disorders, rare disease, systemic lupus erythematosus

Eligibility Criteria

15 Years - 70 Years (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Patients ages 15 to 70 with symptomatic systemic lupus erythematosus meeting American Rheumatism Association criteria and normal controls --Prior/Concurrent Therapy-- No requirement for tetracycline or other photosensitizing drugs

Sites / Locations

  • General Clinical Research Center and Charity Hospital (University of Louisiana)Recruiting
  • Alton Ochsner Medical Foundation HospitalRecruiting

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
October 18, 1999
Last Updated
June 23, 2005
Sponsor
National Center for Research Resources (NCRR)
Collaborators
Louisiana State University Health Sciences Center in New Orleans
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1. Study Identification

Unique Protocol Identification Number
NCT00004375
Brief Title
Ultraviolet Light Therapy for Systemic Lupus Erythematosus
Study Type
Interventional

2. Study Status

Record Verification Date
January 2004
Overall Recruitment Status
Unknown status
Study Start Date
September 1991 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
National Center for Research Resources (NCRR)
Collaborators
Louisiana State University Health Sciences Center in New Orleans

4. Oversight

5. Study Description

Brief Summary
OBJECTIVES: I. Evaluate the mechanisms of ultraviolet A-1 light therapy in patients with systemic lupus erythematosus and normal controls.
Detailed Description
PROTOCOL OUTLINE: Treatment with ultraviolet A-1 light is administered 5 days a week for 6 weeks, at the lowest dose or frequency required to maintain a response. The dose and frequency are progressively decreased over the next 9 weeks.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Systemic Lupus Erythematosus
Keywords
arthritis & connective tissue diseases, immunologic disorders and infectious disorders, rare disease, systemic lupus erythematosus

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 2
Enrollment
20 (false)

8. Arms, Groups, and Interventions

Intervention Type
Procedure
Intervention Name(s)
ultraviolet A-1 light treatment

10. Eligibility

Sex
All
Minimum Age & Unit of Time
15 Years
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Patients ages 15 to 70 with symptomatic systemic lupus erythematosus meeting American Rheumatism Association criteria and normal controls --Prior/Concurrent Therapy-- No requirement for tetracycline or other photosensitizing drugs
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Hugh McGrath, Jr.
Organizational Affiliation
Louisiana State University Health Sciences Center in New Orleans
Official's Role
Study Chair
Facility Information:
Facility Name
General Clinical Research Center and Charity Hospital (University of Louisiana)
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112-2822
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hugh McGrath, Jr.
Phone
504-568-4630
Email
hmcgra@lsuhsc.edu
Facility Name
Alton Ochsner Medical Foundation Hospital
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jawed Alam
Phone
504-842-3314

12. IPD Sharing Statement

Citations:
PubMed Identifier
8869897
Citation
McGrath H, Martinez-Osuna P, Lee FA. Ultraviolet-A1 (340-400 nm) irradiation therapy in systemic lupus erythematosus. Lupus. 1996 Aug;5(4):269-74. doi: 10.1177/096120339600500405.
Results Reference
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Ultraviolet Light Therapy for Systemic Lupus Erythematosus

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