A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study)
Alzheimer Disease
About this trial
This is an interventional treatment trial for Alzheimer Disease focused on measuring Anti-inflammatory
Eligibility Criteria
Inclusion Criteria: NINCDS/ADRDA criteria for probable AD MMSE between 13 and 26, inclusive Stable medical condition for 3 months Screening visit Physically acceptable for this study as confirmed by medical history, physical exam, neurologic exam, and clinical laboratory tests Supervision available for administration of study medications; caregiver/informant to accompany patient to all scheduled visits Fluent in English or Spanish Age greater than or equal to 55 years old Modified Hachinski of less than or equal to 4 CT or MRI since onset of memory impairment demonstrating absence of clinically significant focal lesion Able to complete baseline assessments 6 years of education or work history sufficient to exclude mental retardation Able to ingest oral medication Exclusion Criteria: Hypersensitivity to aspirin or NSAID Active peptic ulcer disease within 5 years Renal insufficiency with creatinine greater than 1.5 Clinically significant liver disease Poorly controlled hypertension Congestive heart failure Bleeding ulcer Active neoplastic disease (skin tumors other than melanoma are not exclusionary; patients with stable prostate cancer may be included at the discretion of the project director) Inflammatory diseases (including crystal arthropathy, rheumatoid arthritis, systemic lupus, erythematosus, Sjogren's syndrome, inflammatory bowel disease)
Sites / Locations
- Barrow Neurological Group
- University of Arizona, Tucson
- University of California Irvine Institute for Brain Aging and Dementia
- University of California, San Diego
- University of Southern California
- University of California, Los Angeles
- University of California, Davis
- Yale University, School of Medicine
- Georgetown University Medical Center
- Baumel-Eisner Neuromedical Institute, Boca Raton
- Baumel-Eisner Ft Lauderdale
- Mayo Clinic Jacksonville
- Wein Center
- Baumel-Eisner Neuromedical Institute, MiamiBeach
- University of South Florida
- Premiere Research Institute
- Emory University
- Rush Presbyterian St. Luke's Medical Center
- Indiana University Medical Center
- Kansas University
- University of Kentucky
- University of Michigan
- University of Minnesota
- Washington University
- University of Nevada
- ClinSearch, Inc
- New York University Medical Center
- Columbia University
- University of Rochester Medical Center
- University Hospitals of Cleveland
- Oregon Health Sciences University
- University of Pennsylvania
- University of Pittsburgh
- Memorial Hospital of Rhode Island
- Medical University of South Carolina
- Vanderbilt University Medical Center
- University of Texas, SW Medical Center
- Baylor College of Medicine
- Southwestern Vermont Medical Center
- University of Washington