Repetitive Transcranial Magnetic Stimulation for "Voices"
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring neurologic and psychiatric disorders, rare disease, schizophrenia
Eligibility Criteria
PROTOCOL ENTRY CRITERIA: Inclusion criteria: Diagnosis of schizophrenia or schizoaffective disorder based on DSM-IV version of SCID Auditory hallucinations of spoken speech occurring at least 5 times per day where subject able to discern verbal content Right-handed At least 4 weeks on stable antipsychotic medication Exclusion criteria: history of seizure (unless due to drug withdrawal or medication that is no longer prescribed) history of epilepsy in first degree relatives estimated IQ less than 80 unable to provide informed consent significant unstable medical condition current treatment with clozapine or bupropion cochlear implants or other metal in the head (surgical, etc.) history of cardiac arrhythmia cardiac pacemaker active drug or alcohol abuse within prior 6 weeks pregnancy
Sites / Locations
- Yale University School of Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
active rTMS
sham stimulation
1-Hz rTMS delivered to left temporoparietal cortex at 90% motor threshold for 16 minutes per session given one session per day for nine consecutive days (with the exception of weekends)
Sham stimulation delivered 16 minutes per session given one session per day for nine consecutive days (with the exception of weekends)