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Brain Processing of Language Meanings

Primary Purpose

Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma

Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
National Institutes of Health Clinical Center (CC)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Central Nervous System Disease focused on measuring Cognitive Processes, Inferential Ambiguities, Language Processes, Lexical Ambiguities, Suppression Mechanism, Discourse Processes, Discourse Production Analysis, Magnetic Resonance Imaging, Prefrontal Cortex Function, Aging Effects, Garden Path Phenomena, Text Integration

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria: All subjects will be between the ages of 18-80, fluent English speakers, premorbidly right handed, and literate for stimulus sentences that are written at a minimum of a 4th grade reading level. In addition, all subjects will have a minimum high school or GED education, sufficient hearing acuity (aided or unaided) and auditory comprehension to follow task instructions, adequate visual acuity (aided or unaided) to read at least 14 pt. print on a computer screen, and adequate dexterity to press keyboard keys in response to stimuli. Healthy subjects will have no history of mental, cognitive or other neurological deficits, adequate hearing and visual acuity (corrected or uncorrected) to follow task instructions and read at least 14 pt. print on a computer screen, and adequate dexterity to press keyboard keys to response stimuli. As with BD subjects, healthy subjects will be right handed, native English speakers, and literate for stimulus sentences. The Mini-Mental State Examination (Folstein et al., 1975) will be administered as a cognitive screen for healthy subjects, using a cut-off score of 27 (of total 30) for inclusion on the protocol. For prefrontal BD subjects, only adult patients with focal damage confined to the prefrontal lateral or orbitomedial areas of either or both hemispheres will be included in the study. Cortical damage will be determined on the bases of neurological and neuropsychological examinations and confirmed by MRI or CT studies. All patients with stroke and penetrating head injury will be tested at least 3 months post-onset of neurological damage to ensure a stable medical condition. All patients with resected brain tumor will have completed radiation therapy and regimen of steroid medication. Dates and course of radiation therapy will be documented. It should be emphasized that the BD subjects to be included on this protocol will have selective deficits (on the basis of neuropsychological test findings and screening to determine candidacy) and will be able to understand the purpose of our studies, the instructions for our tasks, and response demands. Patients who cannot understand the purpose of our studies, or the instructions or response demands of the tasks would not meet entry criteria. Only those subjects who pass the screening will be accepted on the protocol. Exclusion Criteria: Healthy subjects will have no history of mental, cognitive or other neurological deficits.

Sites / Locations

  • Warren G. Magnuson Clinical Center (CC)

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
March 23, 2000
Last Updated
March 3, 2008
Sponsor
National Institutes of Health Clinical Center (CC)
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1. Study Identification

Unique Protocol Identification Number
NCT00005004
Brief Title
Brain Processing of Language Meanings
Official Title
Investigations in Discourse Processes
Study Type
Observational

2. Study Status

Record Verification Date
March 2005
Overall Recruitment Status
Completed
Study Start Date
March 2000 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
March 2005 (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
National Institutes of Health Clinical Center (CC)

4. Oversight

5. Study Description

Brief Summary
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible. The study will include two parts: An investigation of the role of the prefrontal cortex of the brain in discourse processing will compare test performance of patients with prefrontal cortex damage with that of healthy age-matched normal volunteers. An investigation of the role of aging in discourse processing will compare test performance of young healthy subjects (18 to 40 years old) with older healthy subjects (41 to 80 years old). All study candidates-both normal volunteers and patients with brain damage-must be at least 18 years old, speak English as their native language, have a high school degree or equivalent (GED), read on a minimum fourth grade level and be right-handed. Study candidates who have central nervous system disease, dysfunction or trauma will have a routine history and neurological examination. They will also undergo neuropsychological testing if they have not already done so. Patients with neurological damage who have not had a magnetic resonance imaging (MRI) scan within six months or a year will be asked to undergo this procedure. Study participants will take verbal or written tests; sit in front of a computer screen and press computer keys in response to what they are shown; answer questions from an examiner, which may be tape-recorded; and fill out questionnaires. There will be rest breaks between tasks. The studies will be spread over three to four days, with sessions lasting from 30 minutes to three hours.
Detailed Description
This protocol is designed to acquire a better understanding of the underlying cognitive mechanisms involved, and the roles of the prefrontal cortex and normal aging, on various aspects of discourse processing. For Phase 1 of the investigations, two investigations will be conducted: Study 1 will compare the performance of patients with prefrontal cortical damage with age-matched healthy controls; Study 2 will compare the performance of young healthy subjects with older healthy subjects in various aspects of on-line discourse processing. The primary focus of our investigations will be on the cognitive mechanism of suppression, which allows selection of appropriate meanings when information is ambiguous. A secondary focus will be on the cognitive processes involved in comprehending explicit and implicit information in stories and appreciating their thematic aspects. In addition, we are interested in learning how individuals comprehend visual (pictorial) versus propositional (textual) representations of relational language concepts (e.g., more/less, front/back). From a cognitive neuroscience perspective, our interests are in investigating the roles of both the prefrontal cortex (i.e., prefrontal lateral and orbitomedial areas of either hemisphere) and the normal aging process in these aspects of discourse processing. We predict that: (1) patients with frontal lobe lesions will have difficulty in suppressing mental activation of inappropriate meanings of ambiguous text at various points during ongoing processing; (2) aging reduces the efficiency of suppressing contextually inappropriate meanings of ambiguous text; (3) prefrontal cortex damage will have deleterious effects on processing implied information in stories and appreciating their thematic aspects, and (4) prefrontal cortex damage will impair visual rather than propositional representations of relational language concepts. Phase 2 of the investigations is designed to extend study into other aspects of text processing as well as expands to the study and analysis of discourse production. Our specific intents are to (1) investigate the processing and use of context when encountering garden path phenomena in text; (2) understand the nature of breakdowns in discourse production during story tell/retell using sequential pictorial stimuli that probe for temporal sequencing of events, cohesive ties, cause/effect relationships, anaphoric reference, inference, and gist; (3) understand what role the prefrontal cortex plays in its ability to formulate a coherent representation in narrative text inferencing tasks. Our findings will be of value in contributing to knowledge about the neural representation of the cognitive mechanisms underlying various aspects of discourse processes; advancing clinical measurements that can pinpoint breakdowns in these processes as they occur in real time, and understanding the effects of normal aging on discourse processes.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury, Healthy, Stroke
Keywords
Cognitive Processes, Inferential Ambiguities, Language Processes, Lexical Ambiguities, Suppression Mechanism, Discourse Processes, Discourse Production Analysis, Magnetic Resonance Imaging, Prefrontal Cortex Function, Aging Effects, Garden Path Phenomena, Text Integration

7. Study Design

Enrollment
500 (false)

10. Eligibility

Sex
All
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: All subjects will be between the ages of 18-80, fluent English speakers, premorbidly right handed, and literate for stimulus sentences that are written at a minimum of a 4th grade reading level. In addition, all subjects will have a minimum high school or GED education, sufficient hearing acuity (aided or unaided) and auditory comprehension to follow task instructions, adequate visual acuity (aided or unaided) to read at least 14 pt. print on a computer screen, and adequate dexterity to press keyboard keys in response to stimuli. Healthy subjects will have no history of mental, cognitive or other neurological deficits, adequate hearing and visual acuity (corrected or uncorrected) to follow task instructions and read at least 14 pt. print on a computer screen, and adequate dexterity to press keyboard keys to response stimuli. As with BD subjects, healthy subjects will be right handed, native English speakers, and literate for stimulus sentences. The Mini-Mental State Examination (Folstein et al., 1975) will be administered as a cognitive screen for healthy subjects, using a cut-off score of 27 (of total 30) for inclusion on the protocol. For prefrontal BD subjects, only adult patients with focal damage confined to the prefrontal lateral or orbitomedial areas of either or both hemispheres will be included in the study. Cortical damage will be determined on the bases of neurological and neuropsychological examinations and confirmed by MRI or CT studies. All patients with stroke and penetrating head injury will be tested at least 3 months post-onset of neurological damage to ensure a stable medical condition. All patients with resected brain tumor will have completed radiation therapy and regimen of steroid medication. Dates and course of radiation therapy will be documented. It should be emphasized that the BD subjects to be included on this protocol will have selective deficits (on the basis of neuropsychological test findings and screening to determine candidacy) and will be able to understand the purpose of our studies, the instructions for our tasks, and response demands. Patients who cannot understand the purpose of our studies, or the instructions or response demands of the tasks would not meet entry criteria. Only those subjects who pass the screening will be accepted on the protocol. Exclusion Criteria: Healthy subjects will have no history of mental, cognitive or other neurological deficits.
Facility Information:
Facility Name
Warren G. Magnuson Clinical Center (CC)
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
8726535
Citation
Faust ME, Gernsbacher MA. Cerebral mechanisms for suppression of inappropriate information during sentence comprehension. Brain Lang. 1996 May;53(2):234-59. doi: 10.1006/brln.1996.0046. Erratum In: Brain Lang 1997 Jan;56(1):159.
Results Reference
background
PubMed Identifier
7087782
Citation
Mani K, Johnson-Laird PN. The mental representation of spatial descriptions. Mem Cognit. 1982 Mar;10(2):181-7. doi: 10.3758/bf03209220. No abstract available.
Results Reference
background
PubMed Identifier
1606490
Citation
Rehak A, Kaplan JA, Weylman ST, Kelly B, Brownell HH, Gardner H. Story processing in right-hemisphere brain-damaged patients. Brain Lang. 1992 Apr;42(3):320-36. doi: 10.1016/0093-934x(92)90104-m.
Results Reference
background

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Brain Processing of Language Meanings

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