Radiation Therapy and Cisplatin in Treating Patients With Advanced Head and Neck Cancer
Head and Neck Cancer
About this trial
This is an interventional treatment trial for Head and Neck Cancer focused on measuring stage III squamous cell carcinoma of the lip and oral cavity, stage IV squamous cell carcinoma of the lip and oral cavity, stage III squamous cell carcinoma of the oropharynx, stage IV squamous cell carcinoma of the oropharynx, stage III squamous cell carcinoma of the hypopharynx, stage IV squamous cell carcinoma of the hypopharynx, stage III squamous cell carcinoma of the larynx, stage IV squamous cell carcinoma of the larynx
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx Stage III or IV No distant metastases PATIENT CHARACTERISTICS: Age: Not specified Performance status: Zubrod 0-1 Life expectancy: At least 6 months Hematopoietic: Absolute granulocyte count at least 2,000/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL SGOT or SGPT no greater than 2 times upper limit of normal Renal: Creatinine no greater than 1.5 mg/dL Creatinine clearance at least 50 mL/min Calcium normal Cardiovascular: No symptomatic coronary artery disease No angina No myocardial infarction within the past 6 months Other: Not pregnant or nursing Fertile patients must use effective contraception No other malignancy within the past 3 years except nonmelanomatous skin cancer PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to the head and neck Surgery: No initial surgery (except diagnostic biopsy of the primary site or neck)
Sites / Locations
- University of Alabama Comprehensive Cancer Center
- Comprehensive Cancer Institute of Huntsville
- Huntsville Hospital System
- Mobile Infirmary Medical Center
- Urology Associates - Mobile AL
- MBCCOP - University of South Alabama
- Alabama Oncology, LLC
- Radiation Oncology Associates of West Alabama
- Providence Cancer Therapy Center
- Arizona Cancer Center
- Mount Diablo Medical Center
- California Cancer Center
- Saint Agnes Cancer Center
- Glendale Memorial Hospital and Health Center
- Sutter Health Western Division Cancer Research Group
- University of California San Diego Cancer Center
- Loma Linda University Medical Center
- Veterans Affairs Medical Center - Long Beach
- Kaiser Permanente Medical Center - Los Angeles
- USC/Norris Comprehensive Cancer Center
- Jonsson Comprehensive Cancer Center, UCLA
- Beckman Research Institute, City of Hope
- CCOP - Bay Area Tumor Institute
- Cancer Care Center
- Radiation Oncology Center - Sacramento
- Radiation Medical Group, Inc.
- UCSF Cancer Center and Cancer Research Institute
- O'Connor Hospital
- CCOP - Santa Rosa Memorial Hospital
- Stanford University
- Memorial Hospital Cancer Center
- University of Colorado Cancer Center
- Bridgeport Hospital
- Whittingham Cancer Center
- CCOP - Christiana Care Health Services
- Walter Reed Army Medical Center
- Lykes Center for Radiation Therapy
- Halifax Medical Center
- Radiation Therapy Associates - Fort Myers
- University of Florida Health Science Center
- Health First Holmes Regional Medical Center
- CCOP - Mount Sinai Medical Center
- Veterans Affairs Medical Center - Miami
- Sylvester Cancer Center, University of Miami
- Baptist Hospital of Miami
- Florida Radiation Oncology Group
- MD Anderson Cancer Center Orlando
- Bay Medical Center
- Gulf Coast Cancer Treatment Center
- West Florida Cancer Institute - Pensacola
- Bayfront Medical Center
- Sarasota Radiation and Medical Oncology Center
- Tallahassee Memorial Healthcare
- H. Lee Moffitt Cancer Center and Research Institute
- Emory University Hospital - Atlanta
- CCOP - Atlanta Regional
- Medical Center/John B. Amos Community Cancer Center
- InterCommunity Cancer Center at Rome
- Northwest Community Hospital
- Northwestern Memorial Hospital
- University of Chicago Cancer Research Center
- CCOP - Central Illinois
- Provena St. Joseph Hospital- Regional Cancer Care Center
- Ingalls Memorial Hospital
- Loyola University Medical Center
- Lutheran General Cancer Care Center
- Methodist Medical Center of Illinois
- St. John's Medical Center
- Veterans Affairs Medical Center - Indianapolis (Roudebush)
- Clarion Health Partners Inc.
- Community Hospitals of Indianapolis - Regional Cancer Center
- Ball Memorial Hospital
- Memorial Hospital of South Bend
- St. Joseph's Radiation Oncology Center
- Wendt Regional Cancer Center of Finley Hospital
- University of Iowa Hospitals and Clinics
- Veterans Affairs Medical Center - Lexington
- Albert B. Chandler Medical Center, University of Kentucky
- James Graham Brown Cancer Center
- Louisville Radiation Oncology
- Merle M. Mahr Cancer Center
- Western Baptist Hospital
- Mary Bird Perkins Cancer Center
- Romagosa Radiation Oncology Center
- MBCCOP - LSU Medical Center
- Tulane University School of Medicine
- CCOP - Ochsner
- Maine Medical Center
- Anne Arundel Oncology Center
- Greater Baltimore Medical Center and Cancer Center
- Harbor Hospital Center
- Sinai Hospital of Baltimore
- Johns Hopkins Oncology Center
- Radiation Oncology Affiliates of Maryland, P.A.
- Peninsula Regional Medical Center
- Cape Cod Hospital
- Veterans Affairs Medical Center - Boston (Jamaica Plain)
- CCOP - Ann Arbor Regional
- University of Michigan Comprehensive Cancer Center
- Barbara Ann Karmanos Cancer Institute
- Henry Ford Hospital
- McLaren Regional Cancer Center
- Hurley Medical Center
- CCOP - Kalamazoo
- Sparrow Regional Cancer Center
- Marquette General Hospital
- MidMichigan Regional Medical Center
- William Beaumont Hospital
- St. Mary's Medical Center
- Mayo Clinic Cancer Center
- CCOP - Metro-Minnesota
- North Mississippi Medical Center/Cancer Center
- Ellis Fischel Cancer Center - Columbia
- CCOP - Kansas City
- St. Louis University Health Sciences Center
- Mallinckrodt Institute of Radiology
- Cancer Research for the Ozarks
- CCOP - Cancer Research for the Ozarks
- CCOP - Montana Cancer Consortium
- Methodist Cancer Center - Omaha
- Nebraska Health System
- CCOP - Southern Nevada Cancer Research Foundation
- Norris Cotton Cancer Center
- Elliot Regional Cancer Center
- Veterans Affairs Medical Center - East Orange
- John F. Kennedy Medical Center
- Trinitas Hospital - Jersey Street Campus
- Monmouth Medical Center
- South Jersey Hospital - Millville
- Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County
- Cancer Institute of New Jersey
- Newark Beth Israel Medical Center
- Atlantic City Medical Center
- Community Medical Center
- St. Francis Medical Center
- Associated Radiologists, P.A.
- Saint Joseph Medical Center
- Cancer Center of Albany Medical Center
- Albert Einstein Comprehensive Cancer Center
- State University of New York Health Science Center at Brooklyn
- New York Methodist Hospital
- Roswell Park Cancer Institute
- Finger Lakes Radiation Oncology, P.C.
- CCOP - North Shore University Hospital
- Beth Israel Medical Center
- NYU School of Medicine's Kaplan Comprehensive Cancer Center
- Memorial Sloan-Kettering Cancer Center
- Herbert Irving Comprehensive Cancer Center
- Champlain Valley Physicians Hospital Medical Center
- Vassar Brothers Hospital
- University of Rochester Cancer Center
- New York Medical College
- Lineberger Comprehensive Cancer Center, UNC
- Northeast Medical Center
- East Carolina University School of Medicine
- Catawba Memorial Hospital
- CCOP - Southeast Cancer Control Consortium
- Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
- Meritcare Roger Maris Cancer Center
- UNIMED Medical Center
- Akron General Medical Center
- Akron City Hospital
- Christ Hospital
- Ireland Cancer Center
- University Hospitals of Cleveland
- Cleveland Clinic Cancer Center
- CCOP - Columbus
- Arthur G. James Cancer Hospital - Ohio State University
- CCOP - Dayton
- CCOP - Toledo Community Hospital Oncology Program
- St. Anthony Hospital
- St. John Medical Center
- CCOP - Columbia River Program
- Lehigh Valley Hospital
- St. Luke's Hospital Regional Cancer Center
- Penn State Geisinger Medical Center
- Mercy Catholic Medical Center, Mercy Fitzgerald Divison
- Delaware County Memorial Hospital
- Penn State Geisinger Cancer Center
- Hahnemann University Hospital
- University of Pennsylvania Cancer Center
- Veterans Affairs Medical Center - Philadelphia
- Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
- Fox Chase Cancer Center
- Albert Einstein Cancer Center
- University of Pittsburgh Cancer Institute
- Mercy Hospital of Pittsburgh
- Western Pennsylvania Hospital
- Reading Hospital and Medical Center
- Mercy Hospital Cancer Center - Scranton
- Wilkes Barre General Hospital
- CCOP - MainLine Health
- York Hospital
- Roger Williams Medical Center/BUSM
- Medical University of South Carolina
- CCOP - Greenville
- CCOP - Upstate Carolina
- Rapid City Regional Hospital
- Jackson-Madison County General Hospital
- Baptist Regional Cancer Center - Knoxville
- CCOP - Baptist Cancer Institute
- University of Tennessee, Memphis Cancer Center
- Vanderbilt Cancer Center
- Harrington Cancer Center
- Julie and Ben Rogers Cancer Institute
- University of Texas Medical Branch
- University of Texas - MD Anderson Cancer Center
- Wilford Hall - 59th Medical Wing
- Joe Arrington Cancer Research and Treatment Center
- Bayshore Medical Center
- East Texas Medical Center - Cancer Institute
- Dixie Regional Medical Center
- University of Utah Health Sciences Center
- LDS Hospital
- CCOP - Southwestern Vermont Regional Cancer Center
- Vermont Cancer Center
- Martha Jefferson Hospital
- Cancer Center, University of Virginia HSC
- RMH Regional Canter Center
- Virginia Baptist Hospital
- Naval Medical Center, Portsmouth
- Swedish Cancer Institute
- Virginia Mason Medical Center
- Deaconess Medical Center
- Yakima Valley Memorial Hospital
- Schiffler Cancer Center
- St. Vincent Hospital
- Gundersen Lutheran Medical Foundation
- Southern Wisconsin Radiotherapy Center
- University of Wisconsin Comprehensive Cancer Center
- Marshfield Clinic
- Community Memorial Hospital
- St. Joseph's Hospital
- Columbia Hospital
- St. Luke's Medical Center
- Medical College of Wisconsin
- Veterans Affairs Medical Center - Milwaukee (Zablocki)
- Southeastern Wisconsin Regional Cancer Center
- Waukesha Memorial Hospital
- Tom Baker Cancer Center - Calgary
- Cross Cancer Institute
- BC Cancer Agency
- Doctor Leon Richard Oncology Centre
- Saint John Regional Hospital
- Dr. H. Bliss Murphy Cancer Centre
- Nova Scotia Cancer Centre
- Cancer Care Ontario-Hamilton Regional Cancer Centre
- Kingston Regional Cancer Centre
- Cancer Care Ontario-London Regional Cancer Centre
- Ottawa Regional Cancer Centre - Civic Campus
- Northeastern Ontario Regional Cancer Centre, Sudbury
- Northwestern Ontario Regional Cancer Centre, Thunder Bay
- Toronto Sunnybrook Regional Cancer Centre
- Princess Margaret Hospital
- Centre Universitaire de Sante de l'Estrie - Site Fleurimont
- Centre Hospitalier de l'Universite de Montreal
- McGill University Department of Oncology
- Saskatoon Cancer Centre