Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation
Intrauterine Growth Retardation
About this trial
This is an observational trial for Intrauterine Growth Retardation focused on measuring endocrine disorders, intrauterine growth retardation, rare disease
Eligibility Criteria
Intrauterine growth retardation (IUGR), defined as birth weight less than 2 standard deviations below the mean by Usher and McLean Deficient "catch-up" growth (stature less than 5th percentile on growth chart after age 18 months) Normal or elevated circulating concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) IGF-I or IGFBP-3 within or above the 95th percentile confidence interval for age No other clinical explanation for poor prenatal and postnatal growth No IUGR due to maternal toxemia, endocrine disease, gastrointestinal disease, significant heart disease, or chromosomal abnormalities No other condition known to retard growth
Sites / Locations
- Emory University School of Medicine
- James Whitcomb Riley Hospital for Children
- Schneider Children's HospitalRecruiting
- Children's Hospital Medical Center - CincinnatiRecruiting
- Medical College of Virginia School of MedicineRecruiting